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Biomedical subjects

Alina Bakunowicz-Lazarczyk

Publications and source records attributed to Alina Bakunowicz-Lazarczyk.

At least 19 recordsLinked to original sources
PubMed2006

IL-8 and IFN-gamma in tear fluid of patients with cystic fibrosis.

Cystic fibrosis (CF) is inherited as an autosomal recessive disorder. It is caused by mutations in the protein-coding gene of chromosome 7, resulting in chronic pulmonary disease and pancreatic insufficiency. The disease affects all secretory epithelia, including the eye. The pathogenesis of ocular changes in CF is still unknown, but the involvement of immunologic processes in patients with CF has been studied in recent years. We measured interleukin-8 (IL-8) and interferon-gamma (IFN-gamma) levels in tears in a group of patients and a group of normal controls to determine if the levels of these cytokines are elevated in CF. The levels of these cytokines in tears and the clinical severity of CF and eye disease were compared. Tear samples were collected from 24 patients with CF at the department of pediatric diseases, Medical University of Bialystok, Poland. Cytokine levels were determined by ELISA. Ophthalmic examinations, including tests for keratoconjunctivitis sicca (dry eye), were used to study the ocular surface. The tear levels of IL-8 and IFN-gamma in the CF patients were significantly higher than those in controls. The clinical severity of CF correlated significantly with the IL-8 and IFN-gamma levels. We found positive correlation between the tear levels of IFN-gamma and dry eye findings in CF patients. Our results suggest that the inflammatory cytokines IL-8 and IFN-gamma may play key roles in the regulation of ocular surface inflammation and the immunologic reaction in patients with CF. The tear levels of IL-8 and IFN-gamma may be candidate markers for evaluation of the clinical status of CF and eye disease. These findings help to provide a new insight into the pathogenesis of dry eye in patients with CF and provide potential targets for therapy.

Adolescent↗
PubMed2006

[The evaluation of the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelial cells of patients with cystic fibrosis].

PURPOSE: To investigate the expression of intercellulare adhesion molecule (ICAM-1) by conjunctival epithelialcells of patients with cystic fibrosis. MATERIAL AND METHODS: 15 patients with cystic fibrosis and 15 control subjects were included in this study. Impression cytology specimens were collected and analyzed by flow cytometry and analyzed by flow cytometry. RESULTS: A significant increase of ICAM-1 expression by epithelial cells was found in patients with cystic fibrosis compared with normal eyes. CONCLUSIONS: Increase of ICAM-1 expression by epithelial cells in cystic fibrosis patients suggests, that the inflammation appears to have a role in the pathogenesis of the ocular surface changes and may be a marker of the inflammatory status in cystic fibrosis.

Adolescent↗
PubMed2006

[Concentration of interleukine-8 in tears in patients with cystic fibrosis].

PURPOSE: To evaluate IL-8 concentration in tears fluid in cystic fibrosis patients. MATERIAL AND METHODS: Tears samples were collected from 18 CF Patients and 18 normal controls. Cytokine level was determined by ELISA. RESULTS: A significant increase of IL-8 concentration in tears fluid was found in CF patients compared with controls. CONCLUSIONS: Increase IL-8 concentration in tears fluid in CF patients suggests a role of immunologic processes in the pathogenesis of the ocular changes, and may be a marker of the inflammatory status in ocular surface in cystic fibrosis.

Adolescent↗
PubMed2005

[Hypertensive retinopathy in child with pheochromocytoma].

AIM: Pheochromocytoma is a tumor secreting catecholamines, it occurs in different age, rarely in children. The disorder coexists with malignant arterial hypertension. We present a case of patient with ophthalmic alterations in the course of pheochromocytoma. MATERIAL AND METHODS: In 12-year old boy operated on pheochromocytoma full ophthalmic examination, fluorescent angiography and ERG were performed. RESULTS: We found decreased visual acuity, hypertensive retinopathy and the scotopic and fotopic ERG alterations. CONCLUSIONS: Hypertensive retinopathy in the course of pheochromocytoma could be the first symptom of the disease, especially in children. The earlier this disorder is diagnosed and operated on, the better is the prognosis for health and regression of retinal findings.

Adrenal Gland Neoplasms↗
PubMed2005

[IFN-gamma in tear fluid in patients with cystic fibrosis].

PURPOSE: To evaluate IFN-gamma concentration in tear fluid in CF patients. MATERIAL AND METHODS: Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA. RESULTS: The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group. CONCLUSIONS: The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.

Adolescent↗
PubMed2005

[High myopia as a pathognomonic sign in Stickler's syndrome].

Stickler's syndrome is an autosomal dominant inherited disorder of connective tissue related to incorrect collagen structure. The changes include ocular, hearing, and joint and bone abnormalities. We present a case of 6-years-old patient with Stickler's syndrome, with characteristic features.

Child↗
PubMed2005

[Progression of diabetic retinopathy in patient with Graves' disease].

The authors present the case of 16-year old girl with diabetes mellitus type 1. She had progression of diabetic retinopathy because of occurrence of Graves' disease. Surgical intervention (strumectomy subtotal, bilateral), was performed and regression of retinal changes was observed.

Adult↗
PubMed2005

Dry eye syndrome and cataract as ocular manifestations of Crohn's disease.

PURPOSE: Crohn's disease is disorder classified under inflammatory bowel disease. Apart from the classic features of the inflamed bowel, patients may develop widespread systemic manifestations, including ocular changes. The authors present a case of ocular complaints in patient with Crohn's disease. MATERIAL AND METHODS: Case report of 11-year-old girl with Crohn's disease. We perform complete ophthalmologic examination and dry eye syndrome tests. RESULTS: A female patient with symptoms of dry eye syndrome and cataract in the both eyes was reported. CONCLUSIONS: Crohn's disease may be associated with ocular findings, such dry eye syndrome and cataract. Evaluation of the eye should be a routine component in the care of patients with Crohn's disease.

Anti-Bacterial Agents↗
PubMed2005

[Neuronal and hormonal regulatory mechanisms of tears production and secretion].

The ocular surface, tear film, lacrimal glands act as a functional unit to preserve the quality of the refractive surface of the eye, and to resist injury and protect the eye against bodily and environmental conditions. Homeostasis of this functional unit involves neuronal and hormonal regulatory mechanisms. The eye appears to be a target organ for sex hormones particulary the androgen, as they modulate the immune system and trophic functions of the lacrimal and Meibomian glands.

Androgens↗
PubMed2005

[Immunological aspects of tear fluid].

The eye is linked to the common mucosal immune system. This system play the part in preservation of the ocular surface. Tear fluid contains pro and anty-inflammatory factors such as lactoferrin, plasmin, immunoglobulins, and a lot of cytokines (interleukins, GM-CSF, TGF alfa and beta). The cornea is immunologicaly preferred, as a result of lack of resident lymphoreticular cells.

Cytokines↗
PubMed2005

[The results of diode laser treatment of retinopathy of prematurity].

PURPOSE: To evaluate the results of diode laser treatment of active phase of retinopathy in prematurity. MATERIAL AND METHODS: We studied 240 premature infants since January 2003 to October 2004. In 60 premature infants (102 eyes--25%) ROP was found. 26 premature infants (52 eyes--43.3%) with threshold ROP (stage 3a) in II zone (12 eyes) and in II and III zone (40 eyes) were treated with an aid of diode laser. Birth weight varied from 650 to 990g (mean 799.23g) and gestational age from 23 to 28 weeks (mean Hbd 26.2). RESULTS: Good anatomical results were obtained in 25 cases (50 eyes--96.15%), in 1 case (2 eyes--3.85%) was total retinal detachment. In this case the progress of retinopathy was caused by small birth weight and other chronic disorders. CONCLUSIONS: Diode laser treatment of active phase of retinopathy in prematurity gives good anatomical results. The results of treatment depend on the other chronic diseases of premature infants.

Female↗
PubMed2004

[Pulsatile ocular blood flow in patients with juvenile glaucoma].

PURPOSE: To compare ocular blood flow in patients with glaucoma juvenile and in normal subjects. MATERIAL AND METHODS: 20 glaucoma juvenile subjects and 20 persons as a control group aged 13 and 17, were matched for intraocular pressure and pulsatile ocular blood flow using pulsatile ocular blood flow (POBF). RESULTS: A positive correlation was found between ocular blood flow in patients with glaucoma juvenile and normal subjects. CONCLUSIONS: 1) POBF is a new and simple tool for the measurement intraocular pressure and pulsatile ocular blood flow and may be useful for diagnosis of the glaucoma. 2) We found a significant difference between ocular blood flow in glaucoma juvenile patients and normal subjects.

Adolescent↗
PubMed2004

[The effectiveness of latanoprost for the treatment of pediatric glaucoma].

Latanoprost is a prostaglandin F2alpha analog that reduces intraocular pressure by 20-40% in adults with open-angle glaucoma. The efficacy and safety of this drug in children has not been widely reported. In our study we evaluated the effect of latanoprost in 14 children aged 12-18 years (mean 15 years): 10 patients with glaucoma juvenile (I group); 2 patients with secondary glaucoma because of uveitis recidivans and 2 patients with aniridia and albinismus (II group). In the I group the average IOP decrement was 9 mmHg or 36.5% (range 29-44%). In the II group the average IOP decrement was 6.5 mmHg or 23.5% (range 11-33%). In one child with aniridia after one year of treatment IOL rose again to 26 mmHg and antiglaucomatous surgery was necessary. Ocular side effects in children of latanoprost are mild.

Adolescent↗
PubMed2004

[Effect of pentoxifylline on Doppler blood flow parameters in the central retinal artery and the short posterior ciliary arteries in adolescents with progressive myopia].

PURPOSE: To evaluate the effect of pentoxifylline on blood flow in the central retinal artery and the short posterior ciliary arteries in patients with progressive myopia. MATERIAL AND METHODS: 48 eyes of 24 healthy patients aged between 12 and 18 years (mean 15.1 years) with myopia from -5.0 to -12.75 Dsph (mean -7.56 Dsph), were examined using color Doppler ultrasonography. The examination was performed before and after 10 days of intravenous administration of 200 mg of pentoxifylline. The peak-systolic, end-diastolic flow velocities, pulsatility, resistance and systolic/diastolic ratios were measured. RESULTS: The use of pentoxifylline significantly increased PSV and EDV in the central retinal artery and in the short posterior ciliary arteries (p=0.0001) in patients with progressive myopia and in the same time decreased PI, RI and S/D (p=0.0001). There was no correlation between Doppler blood flow parameters and dioptres or axial length. CONCLUSIONS: pentoxifylline increases retinal and choroidal blood flow in young patients with progressive myopia.

Adolescent↗
PubMed2004

[MCA/MR anomaly--case report].

PURPOSE: MCA/MR (Cohen syndrome) is a multiple congenital anomalies retardation syndrome with autosomal recessive inheritance. The clinical criteria are nonspecific. The diagnosis was based on the triad: hypotonia, truncal obesity and prominent central incisors. Added to the clinical spectrum ophthalmologic findings such as antymongoloid eye slant and retinal changes, are very important to diagnosis. MATERIAL AND METHOD: The authors present a case of 11-year-old boy with MCA/MR. RESULTS: In this patient we found decreased visual acuity, myopia and retinal abnormalities. CONCLUSIONS: Cohen syndrome is a congenital anomaly with general and ophthalmological findings.

Abnormalities, Multiple↗
PubMed2003

[The surgical results of correcting strabismus with inferior oblique hyperfunction].

PURPOSE: To evaluate the surgical results of correcting strabismus with inferior oblique hyperfunction. MATERIAL AND METHODS: A retrospective chart review of 40 patients, who underwent surgery from 1999-2001 was performed. 7 patients had isolated inferior oblique hyperfunction, 5 with hypertropia, 23 patients had esotropia with inferior oblique hyperfunction and 5 patients had exotropia with inferior oblique hyperfunction. The recession of inferior oblique muscle was undergone in cases with inferior oblique hyperfunction, sometimes in hypertropia with anteposito. The recession-resection of rectus muscles with myotomy-tenotomy of inferior oblique muscle or his recession usually were performed in cases with coexisting esotropia or exotropia. RESULTS: In all cases eyes were acceptably aligned. The recession of inferior oblique muscle is the most effective method of operation in high oblique hyperfunction.

Child↗