Biomedical subjects

Alina Sokup

Publications and source records attributed to Alina Sokup.

6 recordsLinked to original sources

PubMed2006

[Insulin secretion at the diagnosis of gestational diabetes is lower in multiparas than in primiparas].

UNLABELLED: Gestational diabetes mellitus (GDM) has heterogeneous ethiopathogenesis, pathophysiology and clinical features. OBJECTIVES: The aim of the study was to evaluate some of anthropometric parameters, clinical features and indices of insulin resistance and beta cell function in GDM women in first pregnancy and in GDM women in third and following pregnancies. MATERIAL AND METHODS: 877 GDM women, aged 18-48 years were studied. Both groups were compared according to age, BMI before pregnancy, week of GDM diagnosis, weight gain during pregnancy, fasting blood glucose, fasting serum insulin level, HbA1c, insulin resistance and beta-cell function indices. All parameters except BMI were evaluated at GDM diagnosis. RESULTS: Multiparas were older, with higher BMI and lower beta-cell function indices. CONCLUSION: At the moment of GDM diagnosis, insulin secretion evaluated by HOMA indices are lower in multiparas in comparison to primaparas.

Adult↗

PubMed2006

[Insulin resistance in pregnant type 1 diabetic female. Case report].

Insulin resistance may coexist with diabetes type 1 and make treatment of diabetes difficult. Case of 24-year-old type 1 diabetic female with insulin resistance features prior to pregnancy is reported. Exacerbating of insulin resistance during pregnancy was manifested by difficulties to overcome excessive weight gain and necessity to initiate treatment with high doses of insulin. The treatment was based on diet with progressive caloric restriction to 800 kcal/day in 35 week of pregnancy. That diet was continued till the delivery in 37 week. The fast acting analog insulin (Humalog) and long acting insulin (Humulin U) were used in treatment of diabetes. Treatment with low calorie diet did not cause negative effects on diabetic female metabolism and on the neonate state.

Adult↗

PubMed2005

[Effect of family history and clinical features of metabolic syndrome on certain anthropometric, clinical, biochemical, metabolical parameters and the method of diabetes treatment in women with gestational diabetes].

UNLABELLED: Etiopathogenesis of gestational diabetes mellitus (GDM) is still unknown. It has been suggested, that GDM may be a clinical feature of the Metabolic Syndrome (MS). The aim of the study was to asses the effects of parents history of MS clinical features (diabetes mellitus type 2, obesity, arterial hypertension) on certain anthropometric measures, clinical, biochemical and metabolic parameters and on the method of GDM treatment. 156 GDM women aged from 19 to 43 years (mean +/- SD:29.7 +/- 5.8 years) were included in this study. They were divided into two groups, 73 women with positive family history and 83 with negative family history. These groups were compared with regard to age, time of diagnosis of GDM, BMI before pregnancy, increase of weight during pregnancy, fasting glycaemia, fasting insulinaemia, HBA1c, HOMA indices of insulin resistance and method of GDM treatment with regard to maximal doses of insulin used during pregnancy. All parameters except BMI were assessed at the diagnosis of GDM. Gestational diabetics with positive family history of MS clinical features were older (mean +/- SD:30.7 +/- 6.4 vs 28.9 +/- 5.2 years) and have a greater BMI before pregnancy (26.34 +/- 6.12 vs 23.31 +/- 4.7 kg/m2) with GDM diagnosed earlier (29.3 +/- 3.5 vs 30.7 +/- 3.4 week) than in the gestational diabetics with negative family history. There were not significant differences between groups in fasting glycaemia, fasting insulinaemia, increase in weight during pregnancy at GDM diagnosis, HbA1c, HOMA-IR and maximal dose of insulin during pregnancy. There were significant positive correlation between age and BMI in women without family between age and BMI in positive family history group. In both groups were not correlations between age, time of GDM diagnosis and BMI. In positive family history 52% of women were treated with insulin during pregnancy. In negative family history 37% of women were treated with insulin. CONCLUSION: positive one or both parents history of MS clinical features (diabetes mellitus type 2, obesity, arterial hypertension) my be predisposing cause of greater BMI before pregnancy, earlier diagnosis of GDM and more frequently insulin treatment during pregnancy comparing with gestational diabetics with negative family history of analyzed MS clinical features.

Adult↗

PubMed2005

[Outcome of non-pharmacologic treatment in a gestational diabetic woman with high insulin resistance HOMA-IR index and allergy to human insulin. Case report].

Gestational diabetes is a syndrome of significant pathophysiological and clinical heterogeneity. This type of diabetes mellitus can be treated with diet, exercise and insulin in cases of unsatisfactory results of nonpharmacologic treatment. It has been reported the case of a 28-year -old female with gestational diabetes treated with high doses of insulin (128 U/per day) on four injections regimens. During the therapy allergic type III reactions to human insulin preparations (Ultratard HM, Actrapid HM Humulin U, Humulin R, Humalog) has been occurred at the injection site. The insulin was omitted. We applied diet modification and 15-30 minutes walking before meals till the afternoon with god metabolic control. High insulin resistance index HOMA-IR, type 2 diabetes history in both parents god metabolic control of nonpharmacologic treatment, and impaired glucose tolerance after post-partum may suggest, the early stage of diabetes type 2 in presented case.

Adult↗

PubMed2005

[Adhesion molecules in type 2 diabetes].

Abnormal levels some of serum soluble adhesion molecules (ICAM-1, VICAM-1, E-selectin, P-selectin, L-selectin) have been detected in type 2 diabetic patients. There is some evidence that levels of soluble adhesion molecules depend on glycemic control, disturbances of lipid metabolism, obesity and insulin resistance. There is a few of clinical data till now, which have been suggested the significance role of adhesion molecules in pathogenesis of microangiopathy and macroangiopathy in type 2 diabetics. It is possible that in some cases measurement of serum adhesion molecules may be useful for predicting, early diagnosing prophylactic and monitoring of treatment of diabetic type 2 complications. We can modify serum levels of soluble adhesion molecules by nonpharmacologic and pharmacologic treatment.

Cell Adhesion Molecules↗

PubMed2005

[Insulin Lispro as an alternative for insulin Humulin U in the treatment of an obese gestational diabetic woman with allergy to Humulin U. Case report].

It has been reported the case of 32-year-old obese gestational diabetic woman, treated with Humulin U and Humalog from 28 week of gestation. Seventeen days after initiation of insulin Humulin U the woman developed allergic type I cutaneous changes. During the few minutes following injection of Humulin U, the local wheal-flare reactions accompanied by itching has been occurred. These symptoms have been disappeared after a few hours. Insulin Humulin U was discontinued (18 j). Glycemia were monitored every 1-2 hours between 8 pm-6 am. Glycemia were in normal range between 8 pm. till 5 am. We have observed increase of glycemia to 6.34 mmol/l between 5 am.-6 am. The therapy was converted to Humalog injected at 5 30 am with glycemic control one hour later. The glycemic control was very good till next dose of Humalog before breakfast. The doses of Humalog were systematically increased at 5.30 am depend on glycemia at 6.30 with highest doses in 37 week of pregnancy (30 j with 180 j a day). The good glycemic control was maintained till delivery (38 week of pregnancy). That method of therapy was good tolerated and was not strenuous in spite of necessity of early awakening. We suggest that in obese gestational diabetics ultra-short insulin preparation, analog of short acting human insulin (Humalog), injected at 5.30 am might be considered as a therapeutic alteration for long acting insulin injected at evening. This observation may be interesting especially in situations in which long acting insulin injected at evening must be discontinued.

Adult↗