Biomedical subjects

Anders Ebenfelt

Publications and source records attributed to Anders Ebenfelt.

4 recordsLinked to original sources

PubMed2004

Deep neck space infections remain a surgical challenge. A study of 72 patients.

OBJECTIVE: The treatment of deep neck space infections (DNSIs) remains a clinical challenge and these infections are associated with significant risks of mortality. MATERIAL AND METHODS: We analyzed records over a 4.5-year period for all patients with DNSIs who required hospitalization. We recorded age, previous disease, delay in diagnosis, body temperature at admission, C-reactive protein level, X-ray results, location of DNSIs, origin of the infection, spread of infection, use of antibiotics, bacteriology, surgery and outcome. RESULTS: A total of 72 patients (average age 45 years) were included. The locations and spread of DNSIs were described in detail. The commonest origins of DNSIs were dental (n = 35) or salivary gland infections (n = 15). CONCLUSION: Continuous assessment of the patient using CT scans, fine-needle aspiration and physical examinations will determine if and when surgery is necessary. As a large number of DNSIs are of dental origin, it is of great importance that diagnosis and treatment be performed in close cooperation with dental surgeons.

Abscess↗

PubMed2003

Bacterial adherence to mucosal epithelium in the upper airways has less significance than believed.

BACKGROUND: Bacterial adherence to the upper airway epithelium is considered to be an important phenomenon in the pathogenesis of infections. However, the evidence for the hypothesis that bacterial adherence to mucosal epithelial cells has significance for pathogenesis of mucosal infections is based on studies using indirect techniques. We could find no biopsy studies with direct ocular observations of significant numbers of bacteria adhering to upper airway mucosal epithelial cells either in health or during disease. RESULTS: We studied specimens from healthy and infected tonsillar epithelium and specimens from the soft palate epithelium obtained by surgery. The specimens were examined by TEM. In the vast majority of specimens, we found no bacteria adhering to the epithelial cells in the mucosal line regardless of whether the patient was infected or not. Bacteria adhering to shed epithelial cells were seen in higher numbers. Furthermore, as bacteria are small compared to epithelial cells, we calculated the risk of overlooking every adhered bacteria in a section if bacterial adherence was such a significant phenomenon as earlier suggested. We found this risk to be very small. CONCLUSION: We conclude that bacterial adherence to mucosal surface epithelial cells is not a significant phenomenon, either in healthy mucosa in the upper airways or during infection. This is also in line with our earlier results, where we have shown that the site for the infectious process in pharyngotonsillitis is in the secretion on the tonsillar mucosal surface.

Bacteria↗

PubMed2002

Neutrophils are hyperactive in recurrent tonsillitis.

The pathogenesis of recurrent tonsillitis has not been fully explored. Most studies in this field have focused on pathogenic bacteria whereas less research has been done concerning the host defense. In earlier studies it was shown that there is an active cellular defense in the tonsillar surface secretion, consisting of phagocytes, and therefore in this study the possibility that this defense is altered in patients with recurrent tonsillitis was explored. Neutrophils were obtained from tonsillar surface secretions in eight patients with recurrent tonsillitis and eight healthy volunteers and the capacity of the neutrophils to respond to chemotactic stimuli was examined in an in vitro system. A significantly higher fraction of the neutrophils obtained from the patients with recurrent tonsillitis responded to chemotactic stimuli compared to those obtained from the healthy volunteers. It is concluded that there is a hyperactive cellular defense in the tonsillar surface secretion in patients with recurrent tonsillitis. This finding and its significance in the pathogenesis of recurrent tonsillitis are discussed.

Adolescent↗

PubMedDate not supplied

Bacterial location in chronic sinusitis.

BACKGROUND: In chronic nonallergic sinusitis, it is often assumed that bacteria invade the sinus mucosa where the inflammatory condition begins and is maintained. However, the bacterial presence in a normal or moderately damaged epithelial layer has never been proved in biopsy studies. METHODS: In this study, mucosal samples from six consecutive patients with chronic sinusitis were examined. Transmission electron microscopy was used and the presence of bacterial invasion and formation of phagosomes containing bacteria as a marker of host response were studied. RESULTS: Phagocytosis of bacteria was observed in the sinus mucosa in samples from only one patient. In the other five patients, no signs of phagocytosis were seen. CONCLUSION: Based on these results, we concluded that in chronic sinusitis, bacterial invasion in sinus mucosa is not an obligatory phenomenon.

Bacteria↗