Biomedical subjects

Anthony J Petrella

Publications and source records attributed to Anthony J Petrella.

7 recordsLinked to original sources

PubMed2006

Finite element-based probabilistic analysis tool for orthopaedic applications.

Orthopaedic implants, as well as other physical systems, contain inherent variability in geometry, material properties, component alignment, and loading conditions. While complex, deterministic finite element (FE) models do not account for the potential impact of variability on performance, probabilistic studies have typically predicted behavior from simplified FE models to achieve practical solution times. The objective of this research was to develop an efficient and versatile probabilistic FE tool to quantify the effect of uncertainty in the design variables on the performance of orthopaedic components under relevant conditions. Key aspects of the computational tool developed include parametric and automated FE model creation for changes in dimensional variables, efficient solution using the advanced mean-value (AMV) reliability method, and identification of the most significant design variables. Two orthopaedic applications are presented to demonstrate the ability of the computational tool to efficiently and accurately represent component performance.

Finite Element Analysis↗

PubMed2006

Influence of polyethylene creep behavior on wear in total hip arthroplasty.

After total hip arthroplasty (THA), polyethylene acetabular liner creep occurs quickly and serves to increases head-liner contact area and decrease contact pressures. What effect these early changes in contact mechanics will have on the wear behavior of the articulation remains unclear, and hence, selection or modification of polyethylene materials for optimal creep and wear performance is impossible. The objective of this study was to determine the influence of polyethylene creep behavior on volumetric wear and linear creep and wear penetration during simulated gait loading conditions. A finite element model of THA articulation was developed, and simultaneous numerical creep and wear simulation was performed to 10 million gait cycles with three levels of polyethylene creep behavior. Long-term volumetric wear and penetration were surprisingly unaffected by the polyethylene creep behavior due to the competing decrease in contact pressures coupled with increased contact area. In addition, variation in contact mechanics with the creep levels studied was only noteworthy in the initial postoperative period; after 1 million gait cycles, peak contact pressures and areas were within 13% regardless of the creep material behavior selected. Femoral head size had considerable impact on wear and penetration, while liner thickness primarily affected only early penetration. These results suggest that polyethylene creep behavior plays a major role in early penetration, but has little influence on the more important long-term volumetric wear.

Arthroplasty, Replacement, Hip↗

PubMed2006

Effects of knee simulator loading and alignment variability on predicted implant mechanics: a probabilistic study.

Inherent variability in total knee arthroplasty loading and alignment, present in vivo and in simulator testing, may ultimately influence polyethylene tibial insert wear and long-term performance. The effect of this variability was quantified on implant kinematics and contact mechanics during simulated gait loading conditions using semi-constrained and unconstrained fixed bearing, cruciate retaining implants. A probabilistic finite element model of the Stanmore knee wear simulator was utilized to estimate the envelope of anterior-posterior (AP) and internal-external (IE) position and contact pressure and to evaluate the variability in corresponding ranges of motion (ROM). Variability levels were represented by standard deviations of up to 10% of the maximum value for load inputs and 0.25 mm and 0.5 degrees for component alignment inputs. Model predictions compared well with experimental simulator results for the semi-constrained implant, with predicted positional envelopes of up to 1.8 mm (AP) an 3.4 degrees (IE) for the semi-constrained and up to 2.6 mm (AP) and 3.7 degrees (IE) for the unconstrained implant at the variability levels evaluated. ROM varied by up to 22%, while peak contact pressure variations averaged less than 2 MPa for both designs. For each implant, loading variability was more influential during the swing phase of gait, while alignment variability affected kinematics more during stance. The relative rank of sensitivities showed differences between the two designs, providing insight into critical parameters affecting kinematics and contact characteristics.

Arthroplasty, Replacement, Knee↗

PubMed2005

Probabilistic finite element prediction of knee wear simulator mechanics.

Computational models have recently been developed to replicate experimental conditions present in the Stanmore knee wear simulator. These finite element (FE) models, which provide a virtual platform to evaluate total knee replacement (TKR) mechanics, were validated through comparisons with experimental data for a specific implant. As with any experiment, a small amount of variability is inherently present in component alignment, loading, and environmental conditions, but this variability has not been previously incorporated in the computational models. The objectives of the current research were to assess the impact of experimental variability on predicted TKR mechanics by determining the potential envelope of joint kinematics and contact mechanics present during wear simulator loading, and to evaluate the sensitivity of the joint mechanics to the experimental parameters. In this study, 8 component alignment and 4 experimental parameters were represented as distributions and used with probabilistic methods to assess the response of the system, including interaction effects. The probabilistic FE model evaluated two levels of parameter variability (with standard deviations of component alignment parameters up to 0.5mm and 1 degrees ) and predicted a variability of up to 226% (3.44mm) in resulting anterior-posterior (AP) translation, up to 169% (4.30 degrees ) in internal-external (IE) rotation, but less than 10% (1.66MPa) in peak contact pressure. The critical alignment parameters were the tilt of the tibial insert and the IE rotational alignment of the femoral component. The observed variability in kinematics and, to a lesser extent, contact pressure, has the potential to impact wear observed experimentally.

Arthroplasty, Replacement, Knee↗

PubMed2005

Explicit finite element modeling of total knee replacement mechanics.

Joint kinematics and contact mechanics dictate the success of current total knee replacement (TKR) devices. Efficient computer models present an effective way of evaluating these characteristics. Predicted contact stress and area due to articulations at the tibio-femoral and patello-femoral interfaces indicate potential clinical performance. Previous finite element (FE) knee models have generally been used to predict contact stresses and/or areas during static or quasi-static loading conditions. Explicit dynamic FE analyses have recently been used to efficiently predict TKR kinematics and contact mechanics during dynamic loading conditions. The objective of this study was to develop and experimentally validate an explicit FE TKR model that incorporates tibio-femoral and patello-femoral articulations. For computational efficiency, we developed rigid body analyses that can reasonably reproduce the kinematics, contact pressure distribution, and contact area of a fully deformable system. Results from the deformable model showed that the patello-femoral and tibio-femoral kinematics were in good agreement with experimental knee simulator measurements. Kinematic results from the rigid body analyses were nearly identical to those from the fully deformable model, and the contact pressure and contact area correlation was acceptable given the great reduction in analysis time. Component mesh density studied had little effect on the predicted kinematics, particularly for the patellar component, and small effects on the predicted contact pressure and area. These analyses have shown that, at low computational cost, a force-control dynamic simulation of a gait cycle can yield useful and predictable results.

Arthroplasty, Replacement, Knee↗

PubMed2005

Comparison of deformable and elastic foundation finite element simulations for predicting knee replacement mechanics.

Rigid body total knee replacement (TKR) models with tibiofemoral contact based on elastic foundation (EF) theory utilize simple contact pressure-surface overclosure relationships to estimate joint mechanics, and require significantly less computational time than corresponding deformable finite element (FE) methods. However, potential differences in predicted kinematics between these representations are currently not well understood, and it is unclear if the estimates of contact area and pressure are acceptable. Therefore, the objectives of the current study were to develop rigid EF and deformable FE models of tibiofemoral contact, and to compare predicted kinematics and contact mechanics from both representations during gait loading conditions with three different implant designs. Linear and nonlinear contact pressure-surface overclosure relationships based on polyethylene material properties were developed using EF theory. All other variables being equal, rigid body FE models accurately estimated kinematics predicted by fully deformable FE models and required only 2% of the analysis time. As expected, the linear EF contact model sufficiently approximated trends for peak contact pressures, but overestimated the deformable results by up to 30%. The nonlinear EF contact model more accurately reproduced trends and magnitudes of the deformable analysis, with maximum differences of approximately 15% at the peak pressures during the gait cycle. All contact area predictions agreed in trend and magnitude. Using rigid models, edge-loading conditions resulted in substantial overestimation of peak pressure. Optimal nonlinear EF contact relationships were developed for specific TKR designs for use in parametric or repetitive analyses where computational time is paramount. The explicit FE analysis method utilized here provides a unique approach in that both rigid and deformable analyses can be run from the same input file, thus enabling simple selection of the most appropriate representation for the analysis of interest.

Arthroplasty, Replacement, Knee↗

PubMed2004

Finite element simulation of early creep and wear in total hip arthroplasty.

Polyethylene wear particulate has been implicated in osteolytic lesion development and may lead to implant loosening and revision surgery. Wear in total hip arthroplasty is frequently estimated from patient radiographs by measurement of penetration of the femoral head into the polyethylene liner. Penetration, however, is multi-factorial, and includes components of wear and deformation due to creep. From a clinical perspective, it is of great interest to separate these elements to better evaluate true wear rates in vivo. Thus, the aim of this study was to determine polyethylene creep and wear penetration and volumetric wear during simulated gait loading conditions for variables of head size, liner thickness, and head-liner clearance. A finite element model of hip replacement articulation was developed, and creep and wear simulation was performed to 1 million gait cycles. Creep of the liner occurred quickly and increased the predicted contact areas by up to 56%, subsequently reducing contact pressures by up to 41%. Greater creep penetration was found with smaller heads, thicker liners, and larger clearance. The least volumetric wear but the most linear penetration was found with the smallest head size. Although polyethylene thickness increases from 4 to 16 mm produced only slight increases in volumetric wear and modest effects on total penetration, the fraction of creep in total penetration varied with thickness from 10% to over 50%. With thicker liners and smaller heads, creep will comprise a significant fraction of early penetration. These results will aid an understanding of the complex interaction of creep and wear.

Arthroplasty, Replacement, Hip↗