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B B Wheals

Publications and source records attributed to B B Wheals.

At least 19 recordsLinked to original sources
PubMed2001

Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay.

We used a recombinant yeast estrogen assay to assess the activity of 73 phenolic additives that are used as sunscreens, preservatives, disinfectants, antioxidants, flavorings, or for perfumery. Thirty-two of these compounds displayed activity: 22 with potencies relative to 17beta-estradiol, ranging from 1/3,000 to < 1/3,000,000, and 10 compounds with an impaired response that could not be directly compared with 17beta-estradiol. Forty-one compounds were inactive. The major criteria for activity appear to be the presence of an unhindered phenolic OH group in a para position and a molecular weight of 140-250 Da.

Dose-Response Relationship, Drug↗
PubMed1980

Isocratic multi-column high-performance liquid chromatography as a technique for qualitative analysis and its application to the characterisation of basic drugs using an aqueous methanol solvent.

A variety of high-performance liquid chromatography packing materials were prepared and their chromatographic properties compared for separating several basic drugs using a single solvent system. The three most promising packing materials (silica, a mercapto propyl modified silica and a n-propyl sulphonic acid modification) were subsequently used to provide retention volume data for a large number of drugs.

Chromatography, High Pressure Liquid↗
PubMed1979

Simple preparation of a bonded cation-exchange packing material and its application to the separation of phenothiazines by high-performance liquid chromatography.

A method for introducing sulphonic acid groups on to a microparticulate silica is described. This involves formation of a mercaptopropyl bonded phase followed by oxidation to the corresponding sulphonic acid. The packing material so prepared displays cation-exchange properties and has been used to separate phenothiazines.

Antipsychotic Agents↗
PubMed1976

Forensic aspects of high-pressure liquid chromatography.

This paper reviews the applications of high-pressure liquid chromatography (HPLC) to forensic problems, and discusses some of the developments that have taken place in the use of the technique in the Metropolitan Police Laboratory. Preparation of octadecyltrichlorosilane-modified silica is described and some of the chromatographic characteristics of this material are investigated. Applications of HPLC to the analysis of cannabis, opium alkaloids, amphetamine-related materials, LSD and polynuclear hydrocarbons are described.

Alkaloids↗