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Biomedical subjects

B Bültmann

Publications and source records attributed to B Bültmann.

At least 73 records · Page 4Linked to original sources
PubMed1981

Ultrastructural degenerative changes of age-dependent ECHO 9 virus-induced polymyositis in infant mice.

Experimental inoculation of newborn NMRI mice with Echo virus, type 9, strain A. Barty *ECHO 9 virus AB) resulted in diffuse polymyositis 4 days later. The disease, after a delay of 1 day, increased in intensity and was accompanied by a rapid, progressive paresis leading to death 7-11 days following infection. As early as 24-48 h after inoculation, we detected initial ultrastructural degenerative changes, characterized by segmental dilation fo the sarcoplasmic reticulum. Disruption and breakage of myofibrils followed, and lead to the formation of increasing numbers of contraction bands. Ultimately, virus-mediated nuclear and other organellar injury resulted in muscle fiber necrosis. In addition, we observed some substructural cellular events related to virus propagation. Beginning on the 4th day after infection, pronounced proliferation of the sarcoplasmic-reticulum membranes became evident in perinuclear and subsarcolemmal areas in the mature muscle fibers, myoblasts, and post-fused myotubes of mice inoculated within 18 h after birth. These cytological alterations were not noted in the myoblasts and myotubes of NMRI mice injected with virus 2 or 4 days after birth.

Age Factors↗
PubMed1981

In vitro and in vivo studies on filter collected granulocytes.

The in vitro function of granulocytes collected by filtration leukapheresis after premedication of donors with dexamethasone was found to be normal. In vivo studies were performed in a 21-year-old woman who was transplanted with allogeneic bone marrow for severe aplastic anaemia. The patient received granulocyte transfusions for treatment of septicaemia during the transplantation period. On 11 consecutive days an average dose of 7.2 X 10(10) granulocytes/transplantation, the patient died from cardiac failure. Transfused granulocytes were found ante mortem in a pericardial effusion and post mortem in lungs, kidneys, liver and spleen. The data indicate that filter collected granulocytes function normally in the recipient and are clinically effective.

Adult↗
PubMed1981

[Sclerosing mesenteritis: case reports and review of literature (author's transl)].

Sclerosing mesenteritis is a rare, non-systemic disease confined to the mesenteric adipose tissue and typified by a variety of inflammatory pseudo-tumours. Histological investigation uncovers a wide spectrum of pathological changes, with collections of foam cells, fibrosis and for the most part sparse mononuclear inflammatory infiltrates in the mesenteric fat tissue. In the course of several weeks to months the pseudotumours generally resolve without therapeutic measures. The disease entity is discussed on the basis of three clinical cases.

Adipose Tissue↗
PubMed1980

[Influenza A virus infection, a precipitating factor for the major heart attack (author's transl)].

A report on 5 men aged from 53 to 75 years whose clinical symptoms were characterized by a major attack. There was a striking temporal relationship between the onset of this and an influenza infection which, in these 5 patients with chronic heart diseases led to a severe, and in the youngest patient, even to a fatal course. In an acute heart attack it seems rational to take into consideration an acute influenza virus infection as a precipitating factor in existing chronic heart disease and to institute virological studies.

Aged↗
PubMed1980

Interaction of circulating immune complexes with granulocyte function in patients with rheumatoid arthritis.

The sera and peripheral blood granulocytes of 10 patients with rheumatoid arthritis and of 10 healthy controls were investigated for the presence of soluble immune complexes and for cellular dysfunction. Using the Rajicell-radioimmunoassay, immune complexes were detected in 7 out of 10 rheumatoid sera. In one patient the presence of immune complexes was demonstrated by immunofluorescence. In all rheumatoid patients with circulating immune complexes decreased chemotactic reactivity and diminished bactericidal capacity of the neutrophils were observed. Incubation of rheumatoid granulocytes with pooled AB-serum or pretreatment of neutrophils of healthy controls with immune complexes containing rheumatoid sera resulted in a reduced number of comparable cellular dysfunctions including increased release of lysosomal enzymes, strongly correlated with the presence of intracellular phagocytosed immune complexes. Phagocytosis and increase of oxidative cell metabolism during phagocytosis were not influenced by circulating immune complexes. Based on our in vitro findings we suggest that the described immune complex-dependent granulocyte dysfunctions are possible responsible for the high risk of local or systemic bacterial diseases in patients with rheumatoid arthritis.

Adult↗
PubMed1980

[Jaundice-dependent hepatic failure and stress ulcer - an animal experiment].

Experimental studies confirm the clinical results of a correlation between jaundice-dependent hepatic failure and an incidence of stress ulcers: stress ulcers appeared much more frequently in stress-exposed rats with ligation of the choledochus and in animals with operative restitution of the bile flow after ligation of the choledochus than they appeared in controls.

Animals↗
PubMed1979

[Plastic replacement of the abdominal wall by uncoated carbon cloth. An animal experiment on the rabbit (author's transl)].

Carbon cloth is a new biomaterial which is suitable for the replacement of ligaments and connective tissues, because of its biological and physical properties. In 30 rabbits a defect was cut into the abdominal wall. In 20 the defect was covered by an implanted carbon cloth. The other 10 animals were used as controls. After implantation wound healing was excellent. No herniation could be observed in the group with the implants. After 3 months histological examinations revealed the ingrowth of collagen fibres into the carbon cloth. It had become a strong and resilient abdominal wall replacement. A physical-strength test showed stability of the newly formed abdominal wall with good anchorage to normal tissue.

Abdominal Muscles↗
PubMed1979

Beneficial effect of granulocyte transfusions in patients with defects in granulocyte function and severe infections.

A 3-year-old boy (patient A) with a congenital and a 24-year-old man (patient B) with an acquired granulocyte function defect received supportive granulocyte transfusions for the management of severe infections. The boy had suffered from recurrent infections since bith. His granulocytes showed in vitro almost no chemotactic responsiveness, an impaired phagocytosis and reduced intracellular killing of Candida albicans. Family studies suggested that it was an inherited autosomal recessive defect. The child developed a Pseudomonas pneumonia at the age of 3 years, which did not respond to antibiotic therapy. Granulocyte transfusions were then started and soon after the fever and pneumonia disappeared. Patient B showed the haematological signs of a preleukaemic state. He had 3 recurrent episodes of furunculosis which led each time to cellulitis and septic temperatures accompanied by symptoms of an enterocolitis. Tests of granulocyte function in vitro showed reduced intracellular killing of Staphylococcus aureus. Granulocyte transfusions were started, since no clinical improvement could be attained by antibiotics. With transfusion therapy, fever, cellulitis and enterocolitis disappeared each time.

Adult↗
PubMed1978

[Multiple cavernous haemangiomas of the colon (author's transl)].

Extensive involvement of the colon with cavernous haemangioma is described in a 26-year old man. Clinically the disease manifests itself by recurrent rectal bleeding and abdominal distension, leading to his admission. Double contrast examination of the colon showed involvement of the ascending, transverse and descending colon, the sigmoid and the rectum. Arteriography demonstrated vascular tumours in the territory of the jejunal artery, the left colic artery and the superior rectal artery. This is a rare condition which has been described only 53 times in the literature (1, 3, 5, 7). The diagnostic value of double contrast examination of the colon and of selective angiography for differential diagnosis is stressed.

Adult↗
PubMed1977

[Traumatic cysts of the spleen].

During a routine clinical examination of a 7-year-old girl and a 17-year-old man a large tumor was discovered in the left upper quadrant of the abdomen. Large splenic cyst were found in the spleen at splenectomy. The traumatic etiology of the cysts can be assumed on the basis of histologic results, as well as of a significant history of previous trauma. The etiology, differential diagnosis, therapy, and classification of splenic cysts are discussed.

Abdominal Injuries↗
PubMed1976

A case of impaired chemotaxis and lymphocyte transformation.

The report describes the clinical syndroms of a 14-year-old boy which suffered from recurrent infections since early infancy. The clinical and general laboratory findings were similar to "the granulomatous disease of childhood" as described by Bridges et al. (8). The following serum factors were determined: Immunoglobulins, complement factors, isoagglutinins. The following assays with normal or patient's granulocytes were done: Chemotactic activity, nitroblue-tetrazolium test, bactericidal assay, fungicidal assay, myeloperoxidase, monocytes fungicidal assay. Immunological studies include kinetics of phytohaemagglutinin response, effect of serum of the patient on lymphocytic reactivity in vitro and skin tests. The following results were obtained: 1) Assays with normal or patient's granulocytes showed an impaired chemotatic activity, when serum of the patient was added. There was strong indication by treatment of the patient with plasma infusions, that the chemotactic defect is a serum dependent factor. 2) It could be demonstrated that the patient's serum also inhibited the response of lymphocytes to tuberculin and phytohaemagglutinin. Therefore the patient report focuses attention upon the possibility of serum related abnormalities that may influence granulocytic as well as lymphocytic functions leading to recurrent bacterial, fungal and viral infections.

Adolescent↗
PubMed1976

[Dysfunction of Granulocytes in Children with Frequent Infections].

Eight children with various diseases, who has frequent infections were examined for abnormalities of serum proteins and leucocyte function. Inborn or secondary defects could be recognized by the tests for chemotaxis, the intracellular killing of bacteria as well as yeast and the oxydative metabolism of the granulocytes. The defects were serum- or cell-dependent and they could be detected alone or in combination with other dysfunctions. Three children showed a reduced stimulation of the lymphocytes in addition to the impairment of chemotactic activity or fungicidal cavity.

Adolescent↗
PubMed1975

Animal experimental studies on chronic granulomatous inflammation and T-lymphocyte-system.

The presence of lymphocytes in chronic granulomatous inflammations is frequently thought to indicate that thymus-dependent cellular immune mechanisms are involved in the pathogenesis of such processes. Therefore, in the present studies, a model of a granulomatous heaptitis (induced by heat-inactivated group A streptococci) was used to determine whether liver granulomata, consisting of macrophages and lymphocytes, could also be evoked in neonatally thymectomized or in congenitally thymus-deficient nude mice. The morphological (light and electron microscopical, immunohistological) investigations were supplemented with selective determination of T- and B-lymphocyte function. The thymus-deficient mice, after injection of streptococci, developed liver granulomata that did differ neither quanlitatively nor quantitatively from those of control animals with thymus. Lymphocytes were found within the granulomata in both animal groups. There was no evidence for functional disorder of the RES in thymus-deficient mice; on the contrary, RES-activity seemed to be increased. Phagocytosis of streptococci, their intracellular breakdown and streptococcal antigen-degradation occurred as fast or faster in such animals. PHA- and LPS-stimulation of spleen lymphocytes indicated a considerable depletion of T-cells in neonatally thymectomized mice and a complete absence of T-cells in congenitally thymus-deficient nude mice. However, radioimmunological determination of antibodies to group A streptococcal carbohydrate revealed that both groups of experimental animals possessed functionally active B-cells. Therefore, the granulomatous hepatitis described here can be defined as a focal reaction of the liver RES with "B-lymphocyte trapping". Cellular immune mechanisms are not involved in the pathogenesis of these lesions.

Animals↗