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Biomedical subjects

B Błaszczyk

Publications and source records attributed to B Błaszczyk.

68 records · Page 4Linked to original sources
PubMed1978

Experimental allergic encephalomyelitis in chickens.

Experimental allergic encephalomyelitis (EAE) in chickens of the inbred lines IC, CB, WB and (CBxIC)F1 hybrids was investigated. The IC line and (CBxIC)F1 hybrids gave the best reactions. In bursectomized chickens only slight changes in brain were observed. The intensity of EAE in thymectomized chickens was highly suppressed. Using the anti-T and anti-B sera it was shown that, the percentage of EAE of B lymphocytes was increased. Among the used several immunosuppressive drugs which generally decreased inflammatory reactions in brain the best results were observed with azathioprine and actinomycin D. Moreover, cyclophosphamide gave the worse results which was shown in the same experiments. The aim of our experiments was to define the role of thymus and bursa of Fabricius and peripheral B and T lymphocytes in the course of EAE. Moreover, the effect of immunosuppressive drugs on EAE was studied.

Animals↗
PubMedDate not supplied

[Percutaneous vertebral surgery. Indications, technics and possibilities].

UNLABELLED: The authors report their own experience with percutaneous vertebroplasty, one of the so called--minimally invasive methods, used to treat a certain group of spinal lesions affecting the vertebral bodies. The paper contains a brief review of the current literature, basic problems, indications and operative technique. The authors remark, that insertion of the needle into the vertebral body gives an access for biopsy before cement injection. This procedure was realised in the case of diagnostic uncertainty. Technical details of transpedicular biopsy are described. The authors present 2 representative cases. FIRST CASE: a female with pathologic fracture of the Th7 vertebral body of osteoporotic origin. TREATMENT: combination of biopsy and vertebroplasty by percutaneous transpedicular approach. Second case: a female with cancer metastasis in L1 vertebral body, vertebroplasty was performed to support the anterior spinal column. Needle insertion was controlled either by radiofluoroscopy or by CT. The authors confirm pain relief related to vertebroplasty.

Biopsy, Needle↗
PubMedDate not supplied

Pharmacological investigations on anti-inflammatory activity of tryptamide (3-nicotinoyl-tryptamine).

The study concerned anti-inflammatory activity of a new tryptamine derivative - tryptamide. This preparation was effective in nonspecific inflammations and those involving immune mechanisms. Only postadjuvant inflammation appeared resistant to its effect. Its particular effectiveness was noted in the experimentally-induced iridocyclitis. Only in few tests, tryptamide was more effective than the reference drug phenylbutazone; in some cases the effect of both drugs was similar, but in the majority of cases tryptamide proved less effective.

Animals↗
PubMedDate not supplied

[Growth hormone levels in the blood serum and cerebrospinal fluid of patients with multiple sclerosis].

In 1984 the authors determined by radioimmunoassay (ORIPI-RIA kit) the serum growth hormone levels in 35 patients with multiple sclerosis (20 M, 15 F) aged from 20 to 54 years, and in 10 cases the determination was carried out in the cerebrospinal fluid (CSF). The control group comprised 40 patients with ischialgia or neuroses. The normal range of GH values in the serum determined with this kit was from 0 to 80 microIU/ml, and the laboratory normal range was from 0 to 10 microIU/ml. The normal GH value for the CSF is being established (calculations based on mean values). No significant differences were observed in the GH concentrations in the serum between the patients and the control group, and between males and females in either group. No significant differences were found also in the GH level in the CSF of males and females with multiple sclerosis. Treatment with corticosteroids received by over 80% of the patients (at least 6 months before the study) caused no significant rise in GH concentration. However, an increasing tendency was observed of GH concentration in patients which requires confirmation in a greater number of cases.

Adult↗
PubMedDate not supplied

[Epileptic seizures in patients with vascular brain lesions].

In a group of 1621 patients with vascular brain lesions (849 males, 772 females) the authors found seizures in 108 cases (56 males, 52 females): in 26 cases of subarachnoid haemorrhage (aneurysms), 6 cerebral haemorrhages, 24 cerebral arterial thromboses, 18 atherosclerosis of brain vessels, 13 cases of embolia, 4 cases of transient cerebral ischaemia, 4 cases of vertebrobasilar insufficiency, 4 cases of cerebrocardiac syndromes, 2 cases of cerebral form of the Winiwarter-Buerger disease and 1 cases each of cerebellar haemorrhage and aortic arch syndrome. In 8 cases family history of epilepsy was elicited. The authors suggest administration of anticonvulsants in justified cases.

Adult↗
PubMedDate not supplied

[Prolactin in the blood serum of patients with multiple sclerosis].

The authors determined in 1984 by radioimmunoassay (INEP kit) the serum prolactin concentration in 76 multiple sclerosis patients (33 males and 34 females) aged from 21 to 53 years, with disease duration from 2 to 30 years. The control group comprised 110 healthy subjects. Normal prolactin values were 150-750 mIU/ml in females and 150-500 mIU/ml in males. In about one-third of the patients raised prolactin level was found which failed to correlate with the age of the patients and with increased beta-endorphin level in them. The authors suppose that hyperprolactinaemia may be of importance in certain clinical signs of multiple sclerosis. Further investigations on prolactin are conducted with reference to the circadian rhythm of prolactin secretion and dynamic tests.

Adult↗
PubMedDate not supplied

[Studying somatosensory evoked potentials for the evaluation of surgical risk in patients operated on for aneurysms of the cerebral arteries].

In the light of an analysis of 31 patients operated upon in the Neurosurgical Department, Royal Hallamshire Hospital in Sheffield the authors tried to assess the usefulness of somatosensory evoked potentials for evaluating the surgical risk in patients with intracranial aneurysms. The analysed material was chosen so that it could be possible to eliminate the influence of factors connected with the operation on the condition of the patients after the operation. The analysis showed that in patients with low amplitude of N20 potential and prolonged CCT the per cent of insatisfactory operation results may be greater, especially in patients in group III of clinical condition according to the classification of Hunt and Hess (4), and CCT in the analysed group was found to be a slightly worse indicator of surgical risk than the amplitude of N20 potential.

Carotid Artery Diseases↗
PubMedDate not supplied

[Analysis of clinico-social features of epilepsy].

The authors studied 286 patients with epilepsy with disease onset past the age of 20 years (176 males, 110 females) from the urban and rural populations. In 57% of cases the aetiology of epilepsy was undetermined. Among the known aetiological factors head trauma accounted for 15.5% of cases, inflammatory processes in the central nervous system for 4.5%, alcoholism for 7%, vascular lesions for 6%, tumours for 5.2%, degenerative and atrophic changes for 1.5%. Over 40% of patients had had attacks for up to 15 years and over 18% for over 20 years. In 80% of cases grand mal seizures occurred, and in 33% of these cases more than 12 attacks occurred annually. Six cases of status epilepticus were observed with 2 deaths. The attacks were precipitated by menstruation, alcohol abuse, infection, stressed, television watching. Among the signs accompanying or following the seizures tongue biting and urination prevailed. Neurological signs were demonstrated in 21% of cases, encephalopathy in 65%, other psychic disturbances in 9.5%. Systematic treatment was received by 75% of the patients (over 80% in urban population), and therapy with multiple drugs was most frequent. Drug-resistant epilepsy was found in 34% of cases. The patients from the rural population had a lower educational level and had more children. About 70% of the patients were in employment.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Fibrin fibrinogen degradation products in the cerebrospinal fluid of neurological patients].

The authors determined FDP levels in the cerebrospinal fluid by the method of Merskey in 214 neurological patients and found raised levels in 58.6% of cases (from 0.1 to 8.0 ug/ml, with normal value range 0-0.5 ug/ml). In the control group the FDP levels in the CSF were normal. No correlation was noted between the FDP levels in the CSF and in blood. Raised CSF FDP level was observed in exacerbations of multiple sclerosis, strokes especially of embolic origin, syringomyelia, bulbar form of amyotrophic lateral sclerosis, epilepsy, migraine, lumbar disc lesions, polyneuropathy, parkinsonism, brain atrophy, after craniocerebral trauma, in Kleine-Levin syndrome. The authors are studying now the course of FDP changes in the CSF in various cases in the aspect of clinical-laboratory correlations.

Adult↗
PubMedDate not supplied

[Late epilepsy among the population of Kielce and selected communities in Kielce province].

The authors defined the morbidity index of late epilepsy (MI) on the ground of notified cases in the population aged over 20 years (with first seizure past the age of 20 years) comprising 228273 individuals (125453 living in towns and 102820 living in villages) in the years 1979-1980. The index was calculated per 1000 of the population. The general index was 2.23 (males--2.77; females--1.72). The value of the index was highest in the age group 20-29 years (3.75) and 40-49 years (2.58) in males, and in females this value was also at its peaks in these age groups (2.63 and 1.93, respectively). In the whole population the index had also two peaks in these age groups: 3.21 and 2.55 respectively. In the urban population the general index was 2.33 (2.77 in males and 1,91 in females) being again highest in the age groups 20-29 and 40-49 years. Similar peaks were found in these age groups in the urban male and female populations. In the rural population the general index was 2.11 (males 2.77, females 1.49) and the peaks were in the age groups 20-29 and 30-39 years. In males these peaks were in the age groups 20-29 and 40-49, and in females in the groups 20-29 and 30-39 years. The lowest index value was in the age group over 60 years in the whole population (1.22), in the urban population (1.62 and in the rural population (0.91). In further studies on epilepsy the method of active search for epilepsy cases with full clinical and epidemiological analysis is being used.

Adult↗
PubMedDate not supplied

[A case of hematomyelia].

The authors report haematomyelia developing in a 43-year-old man following a slight spinal trauma. The clinical course was severe but the prognosis was good.

Adult↗
PubMedDate not supplied

[Klein-Levin syndrome (case report)].

The authors observed the syndrome in a 17-year-old boy weighing 86 kg and training weight-lifting. During between 10 and 20 months he had periods of physiological sleep lasting on the average 7 days, with voracious appetite and dysphoris. In the EEG tracings corresponding to physiological sleep were observed during the somnolence period, later in transient changes appeared, mainly in the forebrain. EDP in the cerebrospinal fluid was raised - 0.4 micrograms/ml (normally 0--0,05 micrograms/ml according to Merskey). The results of other laboratory investigations were normal. Since about 3 months the patient has been completely healthy and his scholastic progress in good. The authors suspect that excessive exertion may be a causative factor in this syndrome when it occurs at the time of adolescence.

Adolescent↗
PubMedDate not supplied

[The importance of computerized tomography and magnetic resonance imaging in the diagnosis of slowly growing cerebral gliomas].

The authors present diagnostic problem in slowly growing brain gliomas. Two illustrative cases are presented. Both were characterized by scant clinical manifestations and long-term course of the illness before the operation. CT examinations repeated in both patients several times in the preoperative period of a few years disclosed unchanging hypodense areas in cerebral hemispheres. No progress in clinical status of the patients and CT imaging of the lesions were observed throughout years of observation (2 and 5 years, respectively). Rapid deterioration of neurological condition in both patients associated with enlargement of the lesions in CT allowed to establish strong suspicion of brain tumour which was confirmed by examination in each case. Histopathological examination revealed malignant gliomas in both cases. The cases confirmed once again the necessity of early MRI examination in patients with hypodense lesions of the brain found in CT. The authors believe that every hypodense area of the brain should be verified by MRI as soon as possible, regardless their size, progress and neurological status of the patient. Such as approach to the diagnosis of hypodense areas in the CT of the brain may prevent a delay in proper treatment as well as malignant transformation of primarily benign lesion.

Adult↗