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Biomedical subjects

B Brun

Publications and source records attributed to B Brun.

At least 109 records · Page 6Linked to original sources
PubMed1978

[Perturbations of the implantation, the foetal growth and the foetal morphogenesis after ligatures of uterine artery terminal vessels in the rabbit (author's transl)].

Uterine terminal vessels are ligatured in the rabbit. These reduction of the utero-placental blood supply during the pregnancy is one "intra-uterine growth retardation" factor. These I.U.G.R. rabbits shown one important decrease of their total cellular population. More the intervention is executed near the term more the cerebral mass is affected. At the beginning of the pregnancy one teratogenic effect is superadded to the I.U.G.R. effect. Modification of the blood supply before pregnancy with the same proceeding product on decrease of the implantation, one I.U.G.R. effect and one teratogenic effect.

Animals↗
PubMed1977

Pure acute monocytic leukemia. A study of 12 cases.

Twelve cases of pure acute monocytic leukemia in adults were studied. They were selected on the basis of the morphology of the blast cells on Romanowsky-stained smears of blood and bone marrow, as well as positivity of the cells for the naphthol ASD acetate esterase reaction specifically inhibited by sodium fluoride. There was no sex predominance. Neoplastic involvement of the skin and/or gingiva was very frequent. The leukemic proliferation in blood and bone marrow consisted of monoblasts, promonocytes and monocytes. The peroxidase reaction was negative or only faintly positive. Serum and urinary lysozyme levels were increased. The blast cells retained their ability to stimulate, in vitro, colony formation by normal bone marrow cells used as targets. All of these characteristics permit specific identification of this type of acute leukemia. The prognosis is grim: only five of 12 patients achieved complete remission, and four of these five had relapses in less than 14 months; the median survival was five months.

Adult↗
PubMed1977

Polycystic disease of the liver. Angiographic diagnosis.

Three cases of the syndrome of polycystic disease of the liver and kidneys are present. The definite diagnoses were established by means of angiography. Exploratory laparotomy was avoided. The incidence and symptoms of the syndrome and the diagnostic potentials of the methods of examination are reviewed. It is concluded that detection of either polycystic liver or kidney disease should initiate examination of the other component of the syndrome as well.

Adult↗
PubMed1977

[81 cases of Hodgkin's disease treated with extensive radiotherapy, including 65 with primary MOPP chemiotherapy (author's transl)].

Study 81 cases of Hodgkin's disease at stages I, II or III led to the following conclusions from a therapeutic standpoint (in relation to the apparent results obtained): The addition of chemotherapy on the form of three courses of MOPP before irradiation improved the results of the latter on the one hand and, principally, by reducing the number of failures and, secondly, by reducing the complications. The addition of chemoprophylaxis by MOPP in patients in complete remission as a result of initial treatment, involving an association of 3 courses of MOPP followed by radiotherapy, was not shown to be useful. A major factor in prognosis would to be the clinical and radiological situation after the first three courses of MOPP (in the context of combined MOPP and radiotherapy) since, despite the later radiotherapy, numerous failures were noted in the absence of remission after the three MOPP treatments, whilst failure rarely occurred under the opposite set of circumstances. This is important, since modest treatment would seem to suffice in patients reacting well to three initial MOPP treatments, whilst it is essential to reinforce it when this is not the case.

Drug Therapy, Combination↗
PubMed1977

[Chemotherapy-radiotherapy association in the treatment of localized forms of Hodgkin's disease. Prognosis of polychemotherapy after three trials of M.O.P.P].

63 patients with Hodgkin disease of limited extent (I, II, III) are treated with two protocols: extended field irradiation versus chemotherapy (M.O.P.P.) + extended field irradiation. Three points are suggested by analysis of the results: 1) Advantage from the combination of chemotherapy-radiotherapy. 2) Resistance to chemotherapy frequent innodular sclerosis. 3) In patients treated with chemotherapy the reaction has a prognostic value: failure of treatment being seen only in patients who did not obtain a complete remission.

Drug Therapy, Combination↗
PubMed1976

[Acute monoblastic leukemia. Clinical and therapeutic aspects in 20 cases].

Twenty cases of acute monoblastic leukemia are studied according to definite criterias: cytology, cytochemical staining, lysozyme production. The study points out the tumoral characters: hematodermy, gingivitis, central nervous system leukemia and the lack of important bone marrow incompetence. 47 per cent of complete remissions are obtained with daunorubicin, aracytin combination therapy. Other useful chemical agents, and prospects for maintenance therapy are discussed.

Adolescent↗
PubMed1976

[Effect of short-term cyclophosphamide administration on rabbit sperm].

Daily injection in the rabbit of 60 mg cyclophosphamide, during four days, product during 8 to 9 weeks one importance decrease of the number and the mobility of the ejaculated spermatozoa. This interval correspond with the spermatogenesis and epididymal transit period. Low doses injections product only one mobility decrease.

Animals↗
PubMed1975

[Post-hepatitic aplasia treated by grafts of allogenic bone marrow. Remission for more than 2 years. Persistance of a total hematopoietic chimera. Graft versus host reaction].

A successfull bone marrow transplant was achieved in a case of post hepatitic aplastic anemia after cyclophosphamide immunosuppression. Caryotype analysis, erythrocytic phenotype and IgG Gm allotype demonstrated evidence of complete chimerism. Anti-thymocyte serum undoubtly was able to suppress a life threatening episode of graft versus host reaction. Severe long lasting skin lesions are now persisting 2 years after the graft.

Adolescent↗