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Biomedical subjects

B Brun

Publications and source records attributed to B Brun.

At least 91 records · Page 5Linked to original sources
PubMed1980

Acute non myeloid leukaemia in adults. Prognostic factors in 92 patients.

An analysis of prognostic factors was performed on a series of 92 adult patients with acute non-myeloid leukaemia (ANML). Four factors were shown to be correlated with a poor short-term prognosis: (1) Neuropathy involving a single cranial nerve (numbness of the chin) as a presenting feature. (2) A low percentage blast cell infiltration of bone marrow (less than 55%). (3) Cytological L2 type or L3 type of cells according to FAB classification proposals. (4) Increased age. Two factors were shown to be correlated with a poor long-term prognosis: 1) A high level of circulating blast cells; 2) A high tumour burden, as in childhood ANML. These two long-term prognostic factors were interrelated. In addition, our results suggested that myelofibrosis could be a poor long-term prognosis factor as well.

Acute Disease↗
PubMed1980

Radiography of the small intestine with large amounts of cold contrast medium.

A rapid method using a large amount of cold Mixobar for radiography of the small bowel without duodenal intubation is presented. The diagnostic value of the method and the transit time were analysed in 203 patients. The quality of the examinations was good. The transit time was reduced compared with conventional methods.

Adolescent↗
PubMed1980

Calcosis in generalized scleroderma.

20 cases of generalized scleroderma with calcinosis, i.e. Thibierge-Weissenbach syndrome, were reviewed concerning the clinical and radiological findings. 60% of the patients complained of esophageal dysfunction, and in 85% radiological abnormalities of the esophagus were found. Gastro-intestinal complaints, with or without radiological changes, were found in accordance with other reports. Decreased pulmonary function was a frequent feature, but only half of these cases showed pulmonary fibrosis on chest X-ray. Calcinosis primarily affects areas of sclerosis, but can be found elsewhere. Six of our patients had intervertebral calcifications in the thoracic and/or lumbar spine. This seems to be a new observation in patients with scleroderma.

Adult↗
PubMed1980

Abdominal aortic aneurysm in combination with retroperitoneal fibrosis.

During the 10 year period 1969-1979 145 patients with abdominal aortic aneurysm and 21 patients with retroperitoneal fibrosis were surgically treated in our department. Five patients had both disorders simultaneously. In four of them one or both ureters were involved in the fibrotic process and ureterolysis was performed in three and a nephrectomy in one. Three patients had the aneurysm resected simultaneously, two of them as an emergency operation because of threatening rupture. In this small group of patients with both disorders, signs and symptoms were the same as those patients with either retroperitoneal fibrosis or aortic aneurysm alone. The question whether retroperitoneal fibrosis in such cases primary or secondary to abdominal aortic aneurysm or they are coincidental, is still unanswered. The treatment of choice is ureterolysis and resection of the aneurysm in a one stage procedure.

Aged↗
PubMed1980

[Study of the vascularization of the epididymis].

The pampiniform system plays an important role in the thermoregulation and the concentration of hormones in the testicle. The study of the vascularization of the testicle and of the epididymis shows an independent vascularity in the case of the rabbit. The arteries of the head of the epididymis leave the spermatic artery before the establishment of the particular relationships which exist between the testicular artery and the pampiniform system. Temperature monitoring shows no difference between these two organs. It appears in this case that the thermo regulation is achieved essentially by the scrotum. It is not possible to say if any hormonal exchange takes place between the testicle and the epididymis.

Animals↗
PubMed1980

[Comments about use of polychemotherapy MOPP associated with radiotherapy in the treatment of early stages of Hodgkin's disease. Preliminary report of 58 patients (author's transl)].

58 patients with early stages of Hodgkin's disease (I, II, III l) were treated by 3 courses of MOPP chemotherapy followed by extended field irradiation. After 31 to 72 months follow up 87,8 p. 100 of patients are alive in complete remission. The study of the group deserves two comments: 1. Adjuvant MOPP polychemotherapy may be useful, only when a complete response is obtained after 3 courses, when it is so a complete remission of long duration may be hoped in nearly 100 p. 100 of cases. 2 After complete remission induced by combined chemotherapy and radiotherapy, maintenance chemotherapy seems to be useless.

Adolescent↗
PubMed1979

Respiratory distress of hyperleukocytic granulocytic leukemias.

The rapid appearance of acute respiratory distress during the course of 25 hyperleukocytic leukemias was associated with the rapid increase of the leukocytosis. The regression of the tachypnea was spectacular when treating hyperleukocytosis by exchange transfusion and chemotherapy. Blood gas studies, although blurred to some extent by in vitro blast consumption of oxygen, showed a hypoxemia with a hypo-or normocapnia. The symptoms seem to be related to the leukostasis by the mechanical obstruction of the pulmonary capillaries. This leukostasis was shown to be responsible for a septal and alveolar oedema. The high frequency of this syndrome during the course of AGL and of acute phase of CGL seems to be linked to the low deformability of the myeloblasts. In CGL at its chronic phase, CLL or even in ALL, the absence of this syndrome could be explained by the greater deformability of the circulating cells. The hyperleukocytic AGL patients which do not have this syndrome are all characterized by a stable or slowly increasing leukocytosis. Thus, this syndrome seems to characterized by hyperleukocytic granulocytic leukemias with a rapid blood leukocyte doubling rate. Treatment in such cases is an emergency.

Adolescent↗
PubMed1979

Familial renal agenesis and urogenital malformations. Seminal vesicle cyst and vaginal cyst with bicornuate uterus in siblings.

A seminal vesicle cyst was found in a 30-year-old man with ipsilateral renal agenesis. His sister had embryologically analogous malformations--Gartner duct cyst, bicornuate uterus and renal agenesis. This seems to be the first reported familial occurrence of these combined malformations. The embryogenesis is reviewed and the diagnostic procedure and treatment are discussed.

Abnormalities, Multiple↗
PubMed1979

[An atypical form of Waldenstrom's macroglobulinaemia with complete remission lasting for more than two years after multiple chemotherapy (author's transl)].

An authentic case of Waldenstrom's macroglobulinaemia without a tumoural syndrome is reported, with initial signs of peripheral pancytopenia. Complete and persistent remission appears to have followed multiple sequential chemotherapy. This very satisfactory and, according to data in the published literature, very rare result suggests that this type of treatment should be prescribed for all patients with macroglobulinaemia with poor prognostic clinical and histological characteristics.

Adult↗