Serological studies in cholera infection in Calcutta (1966-67).
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Biomedical subjects
Publications and source records attributed to B C Deb.
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Serological response to cholera revaccination has been studied in a semi-closed community consisting of individuals mostly in the 2-20-years age-group. The subjects had been inoculated against cholera every year at the beginning of the local epidemic season. Pre- and post-vaccination sera were obtained from 29 subjects inoculated with cholera vaccine (test group) and 28 from subjects inoculated with TAB vaccine (control group). These sera were tested for vibriocidal and agglutination titres. The geometrical means of the vibriocidal and agglutination titres of the post-vaccination sera in the test group rose by 490% and 463% respectively. This booster effect was observed mostly in individuals in the 2-14-years age-group, who had low titres (vibriocidal </=320 and agglutination </=40) in their prevaccination samples. Revaccination, therefore, appears to be useful as a booster for individuals having low titres.
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Cholera carrier studies have been in progress in Calcutta since April 1966, in areas of high endemicity with a population of about 13 000. Carriers are traced through periodic examinations of samples from latrines, users of vibrio-positive latrines, contacts of cases of cholera and apparently healthy persons.The latrine survey showed that 46.2% of the latrines were infected, and brought 54 carriers to light; the over-all carrier rate in the study area was estimated as 1.3%. The carrier rate among household and family contacts of hospital cases of cholera was 1.6%. None of the contacts of 9 persons with choleraic diarrhoea was positive. Vibrios were also isolated from water and flies near positive latrines.The results indicate that carriers can occur even in the absence of overt disease, that infection persists in many households, and that carriers may transmit the infection.
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A double blind study on determination of ABO blood groups of 210 cholera patients, 44 diarrhoea cases due to Vibrio parahaemolyticus, and 148 diarrhoea cases from whom no vibrios could be isolated (control group), was conducted in Calcutta. A statistically significant difference was found in blood group 'O' when comparison was made between control and cholera groups. No significant association was, however, notices between V. parahaemolyticus-induced diarrhoea and ABO blood groups.
In a cross sectional study of total 14514 tribal Nicobarese people of Car Nicobar Island, an union territory of India, situated in Bay of Bengal, morbidity, mortality and treatment practices of diarrhoeal diseases of under-five children were surveyed. The incidence of diarrhoea (0.2 episode/ch.year), Crude death rate (3.6/1000) and IMR (31/1000 live births) were exceedingly low as compared to SouthEast Asian Countries including mainland of India. ORS utilisation rate was high (41%) as compared to the National figure (12.0%). This is the first study of it's kind carried out in this island and amongst the Nicobarese tribe in India. A preliminary study carried out among the mothers of the hospitalised children indicated that protective behaviours like breast feeding, hand washing, use of chlorinated water and proper disposal of stool were regularly being practiced by the community traditionally. An in-depth study on risk factors of diarrhoea in this island can yield useful clue for describing the same.
An out break of acute bacillary dysentery in a village called Dhamasin in Hooghly district of West Bengal was investigated during March 1984. Forty seven percent of families were affected. A total of 91 cases and 2 deaths occurred amongst 937 people giving an over all attack rate of 9.7% and a case fatality rate of 2.2 percent. Highest attack rate (22.7%) was observed in below one year age group. Multiple drug resistant Shigella dysentery type 1 strains were isolated for the first time from 6 out of 22 cases sampled at the domiciliary level. The organism was never isolated earlier during last ten years of surveillance in the infectious Diseases Hospital, Calcutta. Identification of nature of this outbreak and it's causative agent helped to realise the potentiality of extensive spread and paved the way for further investigations. Public health authorities were buffled as the rapid spread of the disease throughout the entire state of West Bengal could not be contained in spite of instituting all probable control measures on war footing.