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Biomedical subjects

B D Fornage

Publications and source records attributed to B D Fornage.

At least 19 recordsLinked to original sources

Ultrasound-guided needle biopsy of the breast and other interventional procedures.

The techniques of and indications for ultrasound-guided needle biopsy of nonpalpable breast lesions are described. High-frequency ultrasonography offers several distinct advantages over sterotaxy and is the technique of choice for guiding the drainage of cysts and fluid collections and the biopsy of any solid mass that can be identified on sonograms. Ultrasonography also can be used for localizing such lesions preoperatively.

Biopsy, Needle

Sonographic appearances of superficial soft tissue lipomas.

High-resolution real-time sonography was used to evaluate 35 superficial soft tissue lipomas. Thirty were located in subcutaneous tissues and 5 in superficial muscles. The lipomas were assessed for location, shape and size, boundaries, echotexture, homogeneity, and sound through transmission. All were elongated, with their greatest diameter parallel to the skin. Twenty-three lipomas (66%) showed a homogenous echotexture. Twenty-one (60%) were well defined, and the remainder showed ill-defined margins blending into the surrounding tissues. Twenty-nine percent of the lipomas were hypoechoic, 22% were isoechoic, 29% were hyperechoic, and 20% showed a mixed pattern. An elongated isoechoic or echogenic mass in the subcutaneous tissues should suggest the diagnosis of lipoma.

Adolescent

Soft-tissue sarcoma: MR imaging vs sonography for detection of local recurrence after surgery.

To determine the value of MR and sonography in detecting local recurrences of soft-tissue sarcomas after surgery, 26 MR and sonographic studies performed in 21 patients were reviewed retrospectively. Recurrences were confirmed histologically in 12 (46%) of 26 studies. The MR images and sonograms were obtained within 1 month of each other. The findings were classified as recurrence, no recurrence, or indeterminate. Sonography was instrumental in guiding fine-needle aspiration biopsy of impalpable lesions. In two cases, the findings on sonography were indeterminate. In both of these cases, the sonograms had been obtained soon after surgery (at 2 and 4 months). The sensitivity and specificity in the detection of local recurrences were 83% and 93%, respectively, for MR and 100% and 79%, respectively, for sonography. These differences were not statistically significant. We conclude that MR and sonography appear to be equally useful in the detection of local recurrences of soft-tissue sarcomas, sonography can be used for routine follow-up and in guiding needle biopsies, sonography may be more difficult to interpret than MR during the early postoperative period, and MR should be used if sonography is inconclusive.

Adolescent

Sonographic appearance and ultrasound-guided fine-needle aspiration biopsy of breast carcinomas smaller than 1 cm3.

The purpose of this study was to review the sonographic appearance and the results of ultrasound-guided fine-needle aspiration biopsies of a series of 49 breast carcinomas smaller than 1 cm3. No tumor was found to be hyperechoic. Contours were irregular in 69% of cases. In 53%, an echogenic rim was present, and the echotexture was nonhomogeneous in 41%. Sound beam attenuation was present in 39%. The ratio of longitudinal diameter to anteroposterior diameter ranged from 0.67 to 2.25 (mean, 1.08 +/- 0.28). Fine-needle aspiration biopsy under continuous real-time sonographic guidance was performed on 36 patients and yielded 30 positive and four suspicious results (sensitivity, 94%), one inadequate specimen, and one false-negative result. With high-resolution hand-held transducers, breast sonography can depict small carcinomas and provides accurate, cost-effective guidance for fine-needle aspiration biopsy.

Adult

[Bilateral encasement of the internal saphenous vein in a patient with lymphoma].

Sonographic findings in a case of bilateral, almost symmetrical encasement of the terminal segment of the great saphenous vein by superficial sub-inguinal lymphomatous masses are presented. Duplex and color Doppler sonography also demonstrated abnormal Doppler signals within the mass. When peripheral, coalescent nodal masses are detected surrounding intact normal vessels, malignant lymphoma should be suspected.

Aged

Thyroid gland: US in patients with Hodgkin disease treated with radiation therapy in childhood.

The authors retrospectively assessed with sonography the prevalence of thyroid gland abnormalities in 30 patients who underwent radiation therapy for Hodgkin disease between 1962 and 1984. Doses ranged from 3,000 to 4,500 rad (3,000-4,500 cGy). Abnormalities were found in the sonograms of 24 patients and included unilateral (n = 6) or bilateral (n = 2) atrophy; multiple hypoechoic lesions smaller than 0.75 cm (n = 18); and dominant cystic (n = 2), solid (n = 3), or complex lesions (n = 4) larger than 0.75 cm. The risk of development of an abnormality increased as the time from irradiation increased and was comparable between patients who did and did not receive chemotherapy as part of the treatment regimen. Although the pathologic correlates of the various abnormalities seen on sonograms may differ, the findings indicate a need for long-term follow-up of patients who underwent cervical irradiation for Hodgkin disease.

Adolescent

Fibroadenoma of the breast: sonographic appearance.

The sonographic patterns of 100 fibroadenomas, including two giant fibroadenomas and two cystosarcoma phyllodes, were reviewed. The lesions were mostly hypoechoic (92%) and homogeneous in echotexture (72%). Twenty-seven percent of fibroadenomas showed irregular margins. Intratumoral calcifications were noted in 10% of lesions. A marked acoustic shadow without associated calcification was seen in six cases. The mean ratio of the length to the anteroposterior diameter of the tumors was 1.84 +/- 0.52 (standard deviation), indicating an elongation along the general orientation of the breast tissue planes. The ratios of length to anteroposterior diameter calculated in two matching groups of small (less than 1 cm3) fibroadenomas and carcinomas differed significantly. State-of-the-art high-frequency transducers, geometric analysis of tumors, and real-time ultrasound-guided fine-needle aspiration biopsy should help to distinguish between benign and malignant solid breast masses.

Adenofibroma

Soft-tissue changes in the hand in rheumatoid arthritis: evaluation with US.

High-frequency (5.0 and 7.5 MHz) ultrasonography (US) was performed in 16 patients with rheumatoid involvement of soft tissues in the hand or wrist; surgery was performed in 11. In 15 (94%) patients, a hypoechoic thickening of one or several tendon sheaths was noted. The thickening ranged from 2 to 13 mm (mean, 5.2 mm +/- 3.0). Complete or partial flexor tendon ruptures were correctly suspected preoperatively at real-time dynamic US examination in three patients. A discrete, elongated, hypoechoic soft-tissue nodule was demonstrated in five patients; one nodule was intra-tendinous. In 10 of 11 patients, US findings correlated well with those of surgery. Real-time US proved highly accurate in demonstrating rheumatoid soft-tissue changes in the hand. A hypoechoic rim around a tendon in the hand or wrist in a patient with rheumatoid arthritis is highly suggestive of rheumatoid tenosynovitis. US also provides surgeons with an accurate preoperative map of the lesions.

Adult

Sonographic detection and fine-needle aspiration biopsy of nonpalpable recurrent or metastatic melanoma in subcutaneous tissues.

Subcutaneous or lymph node metastases from melanoma may not be palpable because of their small size, their distance from the skin surface, or their location in an area of fibrosis due to previous surgery or irradiation. High-resolution sonography has been used to detect clinically occult foci of recurrent or metastatic melanoma, whereas real-time, ultrasound-guided, fine-needle aspiration biopsy provided cytologic confirmation. Following excision of cutaneous melanoma, sonographic follow-up of the areas of the surgical scar and lymphatic drainage is recommended whenever residual disease is suspected or when clinical evaluation is limited by postoperative or postradiation changes. Any nonpalpable hypoechoic mass detected in those areas should have a biopsy under real-time sonographic guidance.

Biopsy, Needle

[Diagnosis of early prostatic cancer. Correlation of in vitro echography and histopathologic mapping].

Sonographic detection of early prostatic carcinoma is based on the depiction of a hypoechoic focus. Thirty-seven correlations between in vitro sonographic patterns and pathologic mapping of prostatectomy specimens could be obtained in 26 patients. It was assumed that carcinomas smaller than 5 mm in diameter could not be visualized on sonography. Sonography identified 4 to 8 carcinomas greater than 5 mm in size (sensitivity, 50%). Of 18 hypoechoic foci, only 4 were carcinomas (positive predictive value, 22%). Among false positive results, 79% corresponded to normal prostatic tissue at pathology. The specificity of the hypoechoic focus as an indicator of cancer was 52% in this series. 36% of the carcinomas were located in the anterior half of the prostate. The carcinomas that were detected on sonography were all hypoechoic.

Adult

Glomus tumors in the fingers: diagnosis with US.

To the author's knowledge, no direct imaging technique has been used routinely in the diagnosis of glomus tumors. Twelve patients with proved glomus tumors of the fingers were examined with high-resolution real-time ultrasound (US). US depicted the tumor preoperatively in nine patients (75%). All detected tumors were hypoechoic on US scans. The smallest tumor detected was 3 mm in diameter. A limitation of US is in the detection of small, flattened subungual lesions. These preliminary observations indicate that US imaging with high-frequency transducers is useful in both the diagnosis and the preoperative three-dimensional localization of glomus tumors.

Adult