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Biomedical subjects

B Daly

Publications and source records attributed to B Daly.

11 recordsLinked to original sources
PubMed1992

Enalapril versus combined enalapril and nadolol treatment: effects on blood pressure, heart rate, humoral variables, and plasma potassium at rest and during exercise in hypertensive patients.

The effect of enalapril alone and in combination with nadolol on resting and exercising blood pressure, heart rate, plasma renin activity, aldosterone, noradrenaline, and potassium levels was studied in 10 hypertensive patients (diastolic blood pressure between 95 and 114 mmHg). Patients received placebo for 4 weeks, enalapril (mean daily dose 24.5 mg) for 8 weeks, and nadolol, 40 mg once daily, was added for the remaining 8 weeks of the study. Exercise testing (modified Bruce, treadmill) was conducted at the end of the placebo run-in phase and at the end of each treatment period. Enalapril reduced resting and exercising blood pressure independent of any change in heart rate: This effect was increased with combination treatment. Plasma renin activity at rest and during exercise was increased by enalapril. Combination treatment attenuated this response and significantly reduced plasma aldosterone. Neither treatment had any effect on plasma noradrenaline levels. Resting plasma potassium levels were increased with combination treatment, whereas both treatment regimens increased plasma potassium levels during exercise. There were no clinically relevant episodes of hyperkalemia. Further investigation is required to qualify the nature of the blood pressure and plasma potassium response with combination treatment.

Adult↗
PubMed1991

Dental care for the homeless over Christmas 1990.

Each year since 1970, the charity CRISIS has provided a place of warmth and shelter for the homeless of London (guests) over the Christmas period. In 1990 they converted a large factory warehouse off the Old Kent Road and set it up to cook meals, provide beds, games, televisions, hairdressing, chiropody, medical and dental care--and information on housing, as well as general advice. Washing and cleaning facilities were provided in Portakabins parked in the yard outside the warehouse. Guests were provided with a complete change of clothing, which were altered to fit if necessary.

Adolescent↗
PubMed1991

The Kilkenny Integrated Oral Health Project.

The Kilkenny Health Project, started in 1985, aims to reduce the level of risk factors in the community for coronary heart disease through health promotion. Dental disease and coronary heart disease share risk factors of tobacco use, alcohol consumption and poor dietary patterns. A baseline oral health survey demonstrated significant levels of dental disease in Kilkenny in the 429 adults and 523 children who were examined there in 1987. Seventy one per cent of adults required treatment for periodontal disease and 49% of children surveyed required treatment for dental decay. The Kilkenny Oral Health Project was developed as a community participation project aiming to reduce the level of common risk factors in the community for coronary heart disease and dental disease. It has run parallel with the main Kilkenny Health Project and is one of the first health promotion projects which has an integrated health message preventing dental disease and coronary heart disease.

Adolescent↗
PubMed1990

Reconstruction of the severely resorbed mandible.

Reconstruction of the severely resorbed mandible has long been a problem. Restoration of function and strength has been impaired by the lack of long-term retention of various bone grafting modalities. The use of hydroxyapatite as a scaffolding material to prolong the retention of grafted bone may hold promise of longer term strengthening by bone grafts. To allow the use of osseointegrated implants with this HA-bone grafting, porous HA (Interpore 200) was used in two patients. Although the 1- and 2-year follow-up of these patients is encouraging, further investigation is needed.

Bone Resorption↗
PubMed1987

Clinical characteristics and resource utilization of ICU patients: implications for organization of intensive care.

We reviewed the clinical characteristics and resource utilization of 391 medical (M) and 315 surgical (S) ICU patients. In general, MICU patients had more physiologic derangement, as determined by the admission, maximal, and average acute physiology scores (APS). SICU patients had more frequent therapeutic interventions as measured by admission, maximal, and average therapeutic intervention scoring system values. Notably, 40% of MICU and 30% of SICU patients never received any active interventions and were admitted strictly for monitoring purposes. Patients on admission with APS less than or equal to 10 had markedly shorter ICU stays, with almost 50% less treatment than patients with APS over 10. Fifty-six percent of patients with APS less than or equal to 10 did not require any active intervention. In contrast, 83% of patients with APS greater than 10 had considerable intensive interventions. These patients required mechanical ventilation, invasive monitoring, and vasoactive drugs more than twice as often as patients with lower APS scores. Consideration should be given, therefore, to the organization of ICUs according to the patient's severity of illness.

Adult↗