PubMed Health⌕ Search

Biomedical subjects

B Debesse

Publications and source records attributed to B Debesse.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Peripheral subpleural intrapulmonary lymph nodes. Apropos of a clinical case and an anatomical case].

The authors report the case of a round, peripheral radiographic opacity ("coin lesion" of English-language authors) which after surgical excision was found to be an intrapulmonary lymph node. In an anatomical study on the lymphatic drainage of pulmonary segments in adults, a similar lesion was found among 483 injected segments. A review of the literature yielded 27 similar cases which are described in detail. These lymph nodes are probably more frequent than is generally believed, as shown by an experimental radiolymphographic study. Such clinical findings will no doubt be rendered more numerous by the improved sensitivity of new medical imaging techniques. Despite hypotheses put forward by the authors, the presence of these lymph nodes, which seem to be acquired by the adult lung, has not yet been explained.

Aged↗
PubMed1988

Metabolic enzymatic activities in the intercostal and serratus muscles and in the latissimus dorsi of middle-aged normal men and patients with moderate obstructive pulmonary disease.

The glycolytic and oxidative enzyme activities (lactate dehydrogenase (LDH), hexokinase (HK), citrate synthase (CS) and 3-hydroxyacyl-CoA-dehydrogenase (HAD] were measured in the fifth internal and external intercostal muscles, in the vertical and horizontal parts of the serratus, an accessory inspiratory muscle, and in a non-respiratory muscle, the latissimus dorsi (LD) of twenty middle-aged men: nine subjects with normal lung function and eleven patients with moderate chronic obstructive pulmonary disease (COPD). In the normal subjects the enzyme activities of the respiratory muscles were similar to those of the LD, and there were no differences between the internal and the external intercostal muscles. In the COPD patients the metabolic activities of HK, CS and HAD were higher in both intercostals than in LD. Furthermore, there was a significant increase in these enzymatic activities as compared to the intercostals of the normal subjects. These data support the hypothesis that the internal and external intercostal muscles play a more important role in COPD patients than in normal subjects. They are consistent with the hypothesis that COPD has an endurance training effect on both intercostal muscles which could compensate for diaphragmatic disuse.

3-Hydroxyacyl CoA Dehydrogenases↗
PubMed1987

[Multiple leiomyomatous pulmonary nodules in women. Apropos of 2 cases of metastasizing benign leiomyoma].

Two cases of multiple pulmonary leiomyomas in women aged 51 and 45 years respectively are reported. The lesions were discovered 21 and 11 years respectively after hysterectomy for uterine fibromyoma without abnormal histological features. The pulmonary nodules were bilateral and either stable or growing slowly. They were revealed by non-specific symptoms. At surgical biopsy the histological picture was one of benign leiomyoma without mitosis. In one of the 2 patients a pulmonary nodule was explored for oestrogen and progesterone receptors with positive results. The various theories on the origin of these multiple leiomyomas are reviewed. Initially regarded as malformative tumours, they were later interpreted as metastases of uterine leiomyomas with a potential for dissemination. The finding of hormone receptors demonstrates a relationship between these pulmonary lesions, uterine leiomyomas and other multifocal leiomyomatous diseases, including lymphangioleiomyomatosis. The slow but benign course of these tumours differentiates them from metastases of low-malignancy leiomyosarcomas.

Female↗
PubMed1986

[Intertracheobronchial lymph nodes: lymph inflow and outflow in lung segments from 200 adult subjects].

Topographic anatomy of the intertracheobronchial lymp nodes has been thoroughly studies and is now well known. Cinetic aspects of the lymphatic flux passing through these lymph nodes is not completely understood. Supleural lymphatics of lung segments were injected in 200 adults. Almost 300 segments were then injected among the different lobes. The intertracheobronchial lymph node group was interested by the afferencies of 3 segments out of 5. It was injected only once out of 5 from the upper lobes but in 90 to 100% of segmental injections of the lower lobes. Nine times out of ten, the middle lobe was drained by this group, the lingula less than on time out of fife. In almost one third of the cases, the injection was localized to this group and without further progression. This phenomenon was more frequent in the injections of the left lung. The other times the injection continued toward the latero tracheal ascendent chains : right paratracheal chain and esophageal-tracheal, left recurrent chain (left latero or paratracheal). In one third of the cases, only one of these chain was interested and in one time out of two, the right paratracheal chain was concerned. The other times, the injection continued in 2 chains, occasionally three. If these findings are analyzed in regard to the side injected, a contralateral lymphatic drainage is observed either from the left or from the right side. Finally, in less than 10% of the cases, there was a drainage of this group towards the thoracic duct in the mediastinum. Scarcely, it was observed a descendant drainage pathway to the abdomen.

Adult↗
PubMed1986

[Autonomous intrathoracic goiter. Apropos of 2 new cases].

An autonomous intrathoracic goiter (AIG) is a thyroid gland formation located in the thorax or, more precisely, the mediastinum. It is not a metastasis of thyroid cancer, and it has no parenchymatous or vascular connections with the cervical thyroid gland. It is fed by thoracic vessels and is observed in the absence of previous thyroidectomy. Its multiple appellations, and the fact that clinical reports often lack precision and detail, complicate investigations concerning AIG, a rare variety of mediastinal goitre (slightly more than 100 cases published). AIG is essentially caused by an abnormal embryonic development of the thyroid gland. It must be distinguished from migratory goitres partially resected and forgotten in the thorax after cervicotomy. This fully mediastinal tumour is usually removed by the thoracic approach.

Adult↗
PubMed1986

[Lymphatic drainage of the pulmonary segments in the adult: clinical facts and anatomical confirmation].

Anatomical descriptions of the pulmonary lymphatics come mostly from data collected on the fetus or the newborn. Few studies refer to the respective drainage of the different segments, owing to their recent identification. However, the surgeon operating a lung must know whether a given region can drain directly into the mediastinal lymph nodes, and where exactly it drains. Clinical observations tend to favour this possibility. In fact, it is not rare that tumors considered as N.O., that is without any involvement of hilum lymph nodes recur in the mediastinum. In addition, the systematic excision of mediastinal lymphatic chains, being carried out by out surgical team for more than 2 years, has shown the presence of mediastinal nodes in a lot of tumors of this type. The anatomical study which started 8 months ago is presented here and fully confirm this theory. Il showed the presence of collectors leading directly to the mediastinal lymph nodes, the possibility of contra-lateral drainage and of ducts leading directly to the supra-clavicular regions.

Carcinoma, Bronchogenic↗
PubMed1985

[Cardiac rhythm disorders after pneumonectomy].

The authors studied 13 cases of arrhythmia following pneumonectomy in a series of 94 pneumonectomies performed in the Thoracic Surgery Unit. The arrhythmias essentially consisted of atrial fibrillation which was well tolerated haemodynamically. It generally occurred in ambulant patients on about the 5th postoperative day. These arrhythmias responded well to treatment with continuous infusion of amiodarone. By comparing the files of the standard series of 94 pneumonectomies to the series of 13 cases of arrhythmia, the authors tried to determine the predisposing causes. The most obvious cause was the opening of the pericardium, but a number of other predisposing factors were detected: not so much hypoxia or hypovolaemia, but, more importantly, an increase in the effusion in the pneumonectomy cavity with displacement of the mediastinum.

Adenocarcinoma↗
PubMed1985

[Cervical tracheogenic air cyst. Apropos of 2 cases].

The authors report 2 cases of gas-containing cervical cysts. Surgical excision by cervicotomy showed that both of these well-defined cysts were attached to the right border of the cervical trachea by a blind "pseudo-pedicle" and were lined with respiratory-type epithelium. These were 2 tracheogenic cysts, analogous to bronchogenic cysts theoretically linked to an abnormality in the development of the bronchial buds during embryogenesis. These two cases were exceptional not only by virtue of their cervical site, but also the fact that they contained air and occurred in already old women.

Aged↗
PubMed1984

[Surgically-treated small size non-small cell bronchopulmonary cancers without adenopathies (T1NO). 5-year survival and site of recurrences].

From October, 1976 to February, 1982, 48 patients with T1N0 non-small cell bronchopulmonary carcinoma were operated upon at the Laennec Hospital, Paris. Their characteristics were: mean age 57 years (range: 43-80 years); sex ratio 23; type of surgery: 35 lobectomies, 11 pneumonectomies, 2 bilobectomies; histology: 30 epidermoid carcinomas, 15 adenocarcinomas, 3 bronchoalveolar carcinomas. On 1st January, 1983, 10 patients had relapsed after a mean complete remission period of 20 months (range: 2-29 months); 5 only had a local relapse. The actuarial probability of relapse at 5 years is 45%. Twelve patients died after a median survival of 21 months (range: 0-44 months). Of these, 3 died post-operatively, 8 after relapse and 1 of infarction during a first complete remission. Most relapses involved the mediastinum (50%) and the brain (30%). As the preventive role of mediastinal and cerebral irradiation has now been demonstrated in more extensive forms of non-small cell carcinomas, such irradiations would be justified in the T1N0 forms.

Actuarial Analysis↗
PubMed1984

[Reversible pulmonary hypoperfusion following proximal bronchial obstruction caused by a benign process].

Obstruction of a major bronchus by a benign lesion can be accompanied by a functional reduction of the perfusion of the distal lung. This disorder is reversible after removal of the obstruction. We present 5 cases of obstruction of a main bronchus with functional exclusion of the affected lung on scintigraphy. The obstructing lesion was carcinoid tumour in 4 cases and a plasmocytic granuloma in another case. The perfusion was found to be restored following the operation (one bronchotomy, three isolated resection-anastomoses and one resection-anastomosis with lobectomy). These disorders are due to reflex phenomena and anatomical modifications related to the trapping effect. These phenomena are revealed by plain chest x-rays and by perfusion and ventilation pulmonary scintigraphy.

Adult↗