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Biomedical subjects

B Debesse

Publications and source records attributed to B Debesse.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

[Experimental study of the effect of membrane oxygenators on the pulmonary structure of the dog and monkey (author's transl)].

Six dogs and 5 monkeys were subject to extracorporeal circulations with membrane oxygenators for various time periods (from 4 to 57 hours). The pulmonary samples, examined with electron microscopy, enabled us to control the appearance of lesions (similar for the two animal species) and to follow their evolution. From the second hour, abnormalities of the capillary endothelium were observed; but at the 6th hour, the lesions had already deeply affected the whole pulmonary structure and became more and more serious. This intrinsic toxicity of membrane oxygenators on the pulmonary structure should incite extreme caution in the use of this method in man.

Animals↗
PubMedDate not supplied

[Experimental study of extra-corporeal circulation with membrane oxygenators: effects on the lung structures of dogs and monkeys (author's transl)].

Six dogs and 5 monkeys underwent extra-corporeal circulations with membrane oxygenators for variable time periods (from 4 to 57 hours). The development and evolution of the lesions, which were similar in the two animal species, were controlled by electron microscopic examination of lung samples. From the 2nd h, abnormalities of the capillary endothelium were observed; but a 6 h, all the inner lung structures were reached and the lesions grew worse with time. Thus, the intrinsic toxicity of membrane oxygenators on lung structures emphasizes that this method should be used with utmost precaution in man.

Animals↗
PubMedDate not supplied

[Functional results of 280 Pean type gastrectomies for chronic Cruveilhier ulcer].

The authors review 216 gastrectomies of Péan type for gastric or duodenal ulcer with a follow up of between one and 12 years. In 91 patients, the follow up was more than five years. Six criteria were adopted for the essessment of the functional results: increase in body weight which may be of several types, the diet, post-prandial symptoms, return to work, asthenia recurrent ulcer. Each of these criteria were studied separately in all operated patients and analysed in relation to the follow up period. Except for recurrent ulcer, with occurred in 2% of cases, the results obtained improved with time. A routine study such as Visick's method completes this presentation. The good and very good results were 81% at 5 years, average results were 16% and poor results 3%. The differences between gastric and duodenal ulcer were negligeable. After comparison with the data in the literature, this level study seemed more interesting than a statistical study.

Adult↗
PubMedDate not supplied

[The failures of surgery in peptic ulcer. Report of 62 reoperations (author's transl)].

62 reoperations were performed in 54 patients for failure of surgery for chronic ulcer. In 15 cases there was a recurrence of an ulcer left in position, in 32 cases there was an anastomotic ulcer, in 4 cases, severe hemorrhage for severe inflammation of the stoma without recurrence of the ulcer and in 11 cases, there were severe functional disorders. The authors are convinced that in the treatment of recurrent ulcer, vagotomy should always complete gastrectomy and vice versa. It is because they did not follow this advice in the early stages that they had to reoperate certain patients several times for new ulcer recurrences. The results of reoperation for functional disorders when indicated in a gastrectomised patient were mediocre in the vagotomised patients.

Adult↗
PubMedDate not supplied

Muscle fibre types in costal and crural diaphragm in normal men and in patients with moderate chronic respiratory disease.

Histochemical muscle fibre composition of human costal and crural diaphragm was determined in biopsies sampled during surgical procedures. Two groups were studied: 10 subjects with normal lung function and 8 patients with chronic obstructive respiratory disease. Muscle fibres were classified as type I (slow twitch) or type II (fast twitch) on the basis of their myofibrillar ATPase pH lability. There was no significant difference in fibre proportions between costal diaphragm (COD) and crural diaphragm (CRD) for both groups of subjects. Yet, in the normal group, the diameters of both types of fibres were larger in COD than in CRD. The diameters of both types of fibres of the obstructive patients were significantly decreased in COD as compared to the normals. Moreover, linear correlations between type I and II fibre diameters and VC, FEV1, FEV1/VC, and body weight were found in COD and not in CRD. The differences found in muscle fibre size support the idea that the mechanical respiratory load is different for COD and CRD, COD being the more important force generator. Chronic obstructive respiratory disease causes a significant decrease in COD fibre size but does not affect CRD.

Adult↗