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Biomedical subjects

B Drozdzowska

Publications and source records attributed to B Drozdzowska.

At least 19 recordsLinked to original sources
PubMed2005

Quantitative ultrasound at the hand phalanges in 2850 females aged 7 to 77 yr: a cross-sectional study.

In the study, skeletal status was evaluated in 2850 females aged 7 to 77 yr using quantitative ultrasound (QUS amplitude-dependent speed of sound [Ad-SoS]). Ad-SoS ranged from 1923 +/- 30 to 1876 +/- 81 m/s, and the peak value (2121 m/s) was achieved in 19-yr-old females. Ad-SoS increased significantly between subgroups aged 11 and 12 yr, 12 and 13 yr, 13 and 14 yr, 14 and 15 yr, and 15 and 16 yr. After the age of 19 yr the only significant drop was noted between age groups 47 and 48 yr. Ad-SoS was regressed on age, weight, and height for age ranges 7 to 11 yr.(before an increase in Ad-SoS), 12 to 19 yr (from the onset of the increase to the peak value), and older than 19 yr to menopause. In females after menopause, years since menopause (YSM) were taken into consideration. In the two youngest groups Ad-SoS was affected positively by age, and in the two next groups, age had a negative influence on Ad-SoS, whereas weight had a negative and height a positive influence in all groups. YSM did not influence the Ad-SoS value. It was concluded that QUS measurements at the hand phalanges are a useful tool in assessment of skeletal status in the female population.

Adolescent↗
PubMed2004

Knowledge about osteoporosis in a cohort of Polish females: the influence of age, level of education and personal experiences.

In this study, a group of 1065 women aged 16-72 years recruited from patients attending general practitioners was studied to investigate knowledge of osteoporosis and attitude towards methods of preventing the disease. The interviews were carried out by students of the Silesian School of Medicine, using a structured questionnaire. The average number of correct answers in the whole population was 7.05, and in women with established osteoporosis 6.89. In the whole population, the majority of answers were correct and ranged from 60% to 95% in seven out of ten questions. The answers for three questions were incorrect in about half or more of the cohort: 53% of subjects considered that osteoporosis could be cured; for 50% of women osteoporosis is a minor health problem (except for the youngest women and women with university education--74% and 69% of correct answers, respectively); and 58% of women considered that those with osteoporosis should not engage in physical activity due to the risk of falling and causing a fracture. A simple chi-squared test was used to show the role of age, level of education and personal experiences with osteoporosis on answers given by the subjects studied. Age (six out of ten answers), level of education (seven out of ten answers) and personal experience (four out of ten answers) significantly affected answers given. The number of correct answers decreased with age and increased with level of education, and there was no systematic influence of personal experience. In summary, data collected provide important information about knowledge of osteoporosis. Generally, the level of knowledge about osteoporosis was high. Higher level of education and younger age improve the knowledge of osteoporosis with no systematic influence of personal experience with the disease.

Adolescent↗
PubMed2004

Quantitative ultrasound at hand phalanges in adults with end-stage renal failure.

The aim of this study was to assess bone status in 220 subjects with end-stage renal failure (ESRF) (146 men, mean age 53.0 +/- 13.9 years and 74 women, mean age 48.1 +/- 14.3 years). The duration of hemodialysis (durHD) and duration of renal insufficiency (durRI) were, in men, 2.6 +/- 3.8 years and 7.7 +/- 8.0 years, and, in women, 2.8 +/- 3.4 years and 9.1 +/- 7.6 years, respectively. ESRF was caused by the following reasons: chronic glomerulonephritis in 92 patients, diabetes in 52, chronic pyelonephritis in 37, polycystic kidney disease in 19, amyloidosis in 5, hypertension in 4 and unknown cause in 11. The control group consisted of 1615 normal healthy subjects (1216 women, mean age 48.1 +/- 12.1 years and 399 men, mean age 52.9 +/- 14.8 years). Mean age did not differ between patients and controls. Skeletal status was evaluated by quantitative ultrasound (US) measurements at the hand phalanges using DBM 1200 (IGEA, Italy) which measures amplitude-dependent speed of sound (Ad-SoS, m/s). The mean value of Ad-SoS in male patients was 1981 +/- 88 m/s, T-score -l2.03 +/- 1.26, Z-score -0.53 +/- 1.7 and, in female patients, 1967 +/- 96 m/s, -2.23 +/- 1.37, -1.41 +/- 1.56, respectively. Respective values in male controls were 2008 +/- 81 m/s, -1.66 +/- 1.16, -0.01 +/- 0.98 and, in female controls, 2026 +/- 81 m/s, -1.4 +/- 1.15, -0.74 +/- 0.86, and were significantly higher than in male (p < 0.001) and female (p < 0.0000001) patients. A correlation analysis of Ad-SoS with durHD and durRI showed that only in males did both factors significantly influence parameters measured (r = -0.26, p < 0.01). Multiple stepwise regression analysis of Ad-SoS on age, durHD, durRI, weight and height was possible to perform only in males and the following equation was established: Ad-SoS = 2545 m/s - 3.09 x age (years) - 5.68 x durHD (years) - 2.15 x height (cm) - 0.99 x durRI (years), p < 0.000001, r = 0.55, SEE = 69.6. Concluding, in subjects with ESRF treated with hemodialysis, skeletal status assessed with the use of quantitative US was affected.

Age Factors↗
PubMed2004

Skeletal status in survivors of acute lymphoblastic leukemia assessed by quantitative ultrasound at the hand phalanges: a longitudinal study.

The skeletal growth in a course of acute lymphoblastic leukemia (ALL) may be affected, and the aim of the longitudinal study was to assess the skeletal status in survivors of (ALL). The studied population consisted of 38 subjects (17 female and 21 male) measured at the age of 13.9 +/- 3.8 years (5.7 +/- 2.9 years after completion of the therapy, 11.0 +/- 14.4 years after diagnosis) and 2 years earlier; compared with 1402 controls (628 female and 774 male). Patients and controls did not differ significantly in regard to age, height or weight. Skeletal status was assessed by quantitative ultrasound (US) measurements at the hand phalanges using the DBM Sonic 1200, which measures amplitude-dependent speed-of-sound, Ad-SoS (m/s). rms CV% was 0.43%. Mean baseline Ad-SoS value in patients was 1990 +/- 76 m/s and, at second measurement, 2045 +/- 86 m/s (p < 0.000001). In 31 patients, Ad-SoS increased and, in one patient, decreased more than the value of the least significant change. In controls, mean Ad-SoS values were 1973 +/- 64 m/s (baseline) and 2016 +/- 86 m/s (follow-up) and did not differ significantly vs. baseline values in patients. At second measurement, Ad-SoS in controls was significantly lower than in patients (p < 0.05). In five patients with low baseline Ad-SoS values, bone mineral density (BMD) at the spine using DPX-L was estimated; baseline mean BMD was 0.95 +/- 0.11 g/cm2, Z-score was 1.25 +/- 0.97 and, at second measurement, 1.16 +/- 0.07 g/cm2, Z-score was 0.23 +/- 0.43. A significant increase in BMD (p < 0.01) and Z-score (p < 0.05) was noted. In patients, Ad-SoS correlated significantly with age, period after completion of the therapy, body size and Tanner stages (r ranged from 0.43 to 0.83, p ranged from 0.0001 to 0.05). It can be concluded that skeletal status assessed by quantitative US at the hand phalanges in survivors of ALL improved significantly over the period of observation.

Adolescent↗
PubMed2003

Quantitative ultrasound of the hand phalanges in patients with genetic disorders: a pilot case-control study.

Skeletal status in subjects with genetic disorders rarely has been a matter of interest, and the risk for osteoporotic fracture in this population is not known. The aim of this study was to estimate ultrasound values in subjects with genetic disorders. In the study 50 patients (36 boys and 14 girls, mean age 11.8 +/- 2.9 years) and 528 healthy controls matched for age and body size (380 boys and 148 girls, mean age 11.9 +/- 2.5 years) were evaluated. Patients with the following disorders were included: Down syndrome, Martin-Bell syndrome, Marfan-Mass phenotype and others. Bone status was assessed by quantitative ultrasound (QUS) of hand phalanges using DBM Sonic 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS, m/s). Ad-SoS was significantly lower in patients than in controls (in the whole group 1,915 +/- 69 m/s vs. 1,970 +/- 62.0 m/s, P<0.0000001; in males 1,917 +/- 73 m/s vs. 1,972 +/- 63 m/s, P<0.000001; in females 1,910 +/- 58 m/s vs. 1,963 +/- 58 m/s, P<0.01). Ad-SoS correlated significantly with age and body size (except for Ad-SoS with age in female patients). In all subgroups of patients (except for the subjects with Marfan-Mass syndrome) Ad-SoS values were significantly lower than in controls. In a multiple, stepwise regression analysis of Ad-SoS on age and body size, in the whole group of patients age and height had significant influence on Ad-SoS, and in controls age, height and weight. In conclusion, the study shows significantly lower phalangeal ultrasound values in subjects with different genetic disorders compared to normal healthy persons.

Adolescent↗
PubMed2003

Skeletal status in males aged 7-80 years assessed by quantitative ultrasound at the hand phalanges.

Skeletal status in males has been assessed by quantitative ultrasound in only a few studies. There is the lack of data concerning age accretion, peak values, and age-decrease of bone parameters in a wide age range. The aim of this study was evaluation of a large, male, normal population (n=1,175) aged 7-80 years, by the use of quantitative ultrasound (QUS), to estimate peak value of phalangeal ultrasound parameter, age-related changes during growing and aging, the influence of body size, and determination of male normative data. In the study, amplitude-dependent speed of sound (Ad-SoS) at the hand phalanges was measured using DBM Sonic 1200 (IGEA, Italy). The precision assessed by root-mean-square coefficient of variation (RMS-CV) was 0.7%. Ad-SoS ranged from 1,916 m/s in the youngest subgroup (7 years of age) to 1,910 m/s in the oldest (75-80 years of age), and the peak value (2,135 m/s) was achieved in 28-year-old males. Ad-SoS did not increase significantly to the age of 13. Ad-SoS increased significantly between subgroups aged 13 and 14 years ( p<0.0001), and at 15 and 16 years of age ( p<0.000001). A significant decrease was noted between the following age subgroups: 35-39 years vs 40-44 years ( p<0.05), 45-49 years vs 50-54 years ( p<0.000001), and 60-64 years vs 65-69 years ( p<0.001). A difference in Ad-SoS values between the youngest subgroup and peak value was 219 m/s, and an increase per year was about 10.4 m/s. From the peak value to the value in the oldest group Ad-SoS dropped by 225 m/s, and the decrease per year was about 4.6 m/s. Multiple stepwise regression analyses of Ad-SoS with age, weight,and height were performed separately for age ranges: 7-13 years (before an increase in Ad-SoS, n=299), 14-28 years (from the onset of the fast increase in Ad-SoS to the peak value, n=370) and for subjects older than 28 years (after an achievement of peak value of Ad-SoS, n=506). The following equations of the multiple stepwise regression were obtained, respectively: Ad-SoS (m/s)=1,624-1.0 x age (years) -2.94 x weight (kg) + 3.06 x height (cm), r=0.48, p<0.000001, SEE=32.0; Ad-SoS (m/s)=1,533+6.87 x age (years) + 2.41 x height (cm) 0.07 x weight (kg), r=0.56, p<0.000001, SEE=54.3; Ad-SoS (m/s)=1,895-3.87 x age (years) - 1.43 x weight (kg) + 2.53 x height (cm), r=0.73, p<0.00001, SEE=54.3. In conclusion, the study results allowed us to determine normative data, to assess a peak Ad-SoS value, its age-related changes and the influence of body size in the male population.

Adolescent↗
PubMed2003

Skeletal status in children and adolescents with chronic renal failure before onset of dialysis or on dialysis.

Bone status was assessed in 15 children and adolescents with predialysis chronic renal failure (CRF) and in 25 subjects with end-stage renal failure (ESRF). The mean age in the whole group was 14.6+/-3.2 years and CRF had been recognized 5.8+/-4.0 years earlier. The mean age, body size, duration of the disease and Tanner stages did not differ significantly between patients with predialysis CRF and ESRF. The control group consisted of 890 healthy subjects matched with patients for age. Bone mineral density (BMD) was measured by DPX-L (Lunar, Madison, WI) at the spine (s-BMD) and total body (TB-BMD); quantitative ultrasound (QUS) was performed by DBM 1200 (IGEA, Italy) at the hand phalanges (Ad-SoS). Laboratory investigations included the evaluation of intact parathyroid hormone (i-PTH), total and ionized serum calcium, and serum phosphate. In the whole group of patients the following mean values were obtained: Ad-SoS 1952+/-79 m/s (significantly lower than in controls, who had Ad-SoS 2022+/-85 m/s, p<0.05; the difference remained significant after adjusting for body mass index), s-BMD 0.87+/-0.22 g/cm2 ( Z-score -1.6), TB-BMD 0.92+/-0.12 g/cm2 ( Z-score -1.44), i-PTH 276+/-300 pg/ml, total calcium 2.46+/-0.19 mmol/l, ionized calcium 1.14+/-0.08 mmol/l, phosphate 1.68+/-0.61 mmol/l. Skeletal measurements correlated significantly with age, body size and Tanner stages (also after adjusting for age), while significant correlations of these parameters with the duration of CRF and laboratory investigations (except of correlations of i-PTH with Ad-SoS and with TB-BMD in predialysis patients) were not observed. None of the studied variables differed significantly between predialysis and dialysis patients. In conclusion, both predialysis and dialysis children and adolescents showed a decrease in BMD and quantitative ultrasound measurements. The severity of skeletal alterations was similar in the early phase (predialysis patients) and end stage (dialysis patients) of the disease and did not show a tendency to progress with CRF duration.

Absorptiometry, Photon↗
PubMed2003

Quantitative ultrasound at the hand phalanges in women on hormone replacement therapy.

The aim of the observational study was to evaluate the influence of hormone replacement therapy (HRT) on the results of quantitative ultrasound (US) at the hand phalanges in 732 women (mean age about 53 years). Among them were 228 postmenopausal women treated within 6 months after the last menstrual bleeding (group 1), 90 postmenopausal women taking HRT after a break between menopause and the onset of the therapy of about 2 years (group 2) and 414 controls. Mean age and body size did not differ significantly between groups studied. Years since menopause (YSM) did not differ significantly between group 2 and controls. Skeletal status was assessed using DBM Sonic 1200 (IGEA, Carpi, Italy), which measures amplitude-dependent speed of sound (Ad-SoS) in m/s. Ad-SoS was significantly higher in both groups on HRT than in controls (p < 0.000001), and in group 1 compared with group 2 (p < 0.05). The duration of HRT did not affect Ad-SoS values. The influence of age on Ad-SoS values was significantly weaker in women on HRT than in controls and YSM did not influence Ad-SoS value in postmenopausal women taking HRT. In controls, YSM negatively and significantly affected Ad-SoS value. In conclusion, HRT administered in perimenopause or early postmenopause had a significant influence on quantitative US measurements at the hand phalanges, and the difference between both treated groups suggests that HRT ought to be indicated directly after the last menstrual bleeding.

Age Factors↗
PubMed2002

Skeletal status in children, adolescents and young adults with end-stage renal failure treated with hemo- or peritoneal dialysis.

The skeletal status in 30 children, adolescents and young adults (18 females, 12 males) with end-stage renal failure (ESRF) aged 9-23 years (mean 15.8 +/- 3.6 years) was evaluated using measurements of bone mineral density (BMD, g/cm2) at the spine and total body (TB) (Lunar DPX-L, USA), quantitative ultrasound (QUS) of the hand phalanges (DBM Sonic 1200, IGEA, Italy) and laboratory investigations (parathyroid hormone, serum total and ionized calcium, serum phosphate). Eleven subjects were treated with hemodialysis and 19 with peritoneal dialysis. The mean value of the amplitude-dependent speed of sound (Ad-SoS, m/s) measured by QUS was significantly decreased in comparison with the value obtained in a group of 686 age-matched controls (1942 +/- 74 m/s vs 2050 +/- 77 m/s, p<0.0001). BMD measurements were also decreased in comparison with mean values for the healthy population (Z-scores for spine -1.47, and for TB -1.53). Duration of dialysis correlated significantly with spine-BMD, TB-BMD and Ad-SoS (r = -0.37, r = -0.45, r = -0.55, respectively, p<0.05), while duration of ESRF did not have such an influence. Laboratory investigations did not correlate with skeletal parameters. Ad-SoS correlated significantly with spine-BMD (r = 0.45, p<0.05) and TB-BMD (r = 0.56, p<0.01). Both QUS and BMD values correlated significantly with Tanner stages (r ranged from 0.59 to 0.69, p<0.001) and did not increase with age except for correlation between age and TB-BMD. In conclusion, skeletal status in the population studied is strongly affected by ESRF. Both QUS and BMD measurements show an ability to express skeletal changes in a similar manner, though the QUS parameter seems to be more sensitive at revealing changes due to renal failure.

Absorptiometry, Photon↗
PubMed2002

Skeletal status in survivors of childhood acute lymphoblastic leukemia assessed by quantitative ultrasound: a pilot cross-sectional study.

Intensive treatment in acute lymphoblastic leukemia (ALL) with the use of multimodality therapies, including radiotherapy, corticosteroids and cytotoxic agents, may lead to disturbances in bone metabolism. The aim of this study was to determine the degree of possible changes in bone status in survivors of ALL. The studied population consisted of 54 subjects aged 13.0 +/- 3.3 years (31 girls and 23 boys). The mean age at diagnosis was 5.5 +/- 3.5 years, age at the completion of therapy was 8.4 +/- 3.5 years, and the period of follow-up was 4.6 +/- 3.4 years. Patients were divided into three subgroups (low-, moderate- and high-risk) according to the presence of risk factors of ALL and compared with 1020 healthy subjects (508 girls and 512 boys). Patients and controls did not differ significantly in regard to age, height, or weight. Bone status was assessed by quantitative ultrasound (US) at right (dominant) hand phalanges using DBM Sonic 1200 (IGEA, Carpi, Italy) that measures amplitude-dependent speed of sound (Ad-SoS, m/s). Root mean square (RMS)_CV% was 0.43%. Mean Ad-SoS values were 2018 +/- 73 m/s in patients and 2003 +/- 80 m/s in controls and did not differ significantly. Ad-SoS tended to be lower in moderate- and high-risk patients, but differences were not significant. Ad-SoS correlated significantly with age in patients (r value ranged from 0.63 to 0.77, p < 0.01) and controls (r value ranged from 0.79 to 0.84, p < 0.0001). In multiple forward regression analysis, the following equation was obtained: Ad-SoS (m/s) = 1878 (m/s) + 11.4 x age at the study (y) + 4.0 x period after therapy completion (y) - 9.5 x duration of the therapy (y). It can be concluded that bone status assessed by quantitative US at the hand phalanges in survivors of acute lymphoblastic leukemia 4.6 years after completion of the therapy is not affected in comparison to healthy controls.

Adolescent↗
PubMed2002

Panoramic-based mandibular indices in relation to mandibular bone mineral density and skeletal status assessed by dual energy X-ray absorptiometry and quantitative ultrasound.

OBJECTIVES: The panoramic-based indices (Mandibular Cortical Index-MCI, the height of mandibular inferior cortex-IC (mm), Panoramic Mandibular Index-PMI, Mandibular Ratio-MR) were used to evaluate their diagnostic efficacy and to determine whether they correlate with bone mineral density (BMD (g/cm(2))) of the mandible and hip, and with ultrasound parameters of the calcaneus and hand phalanges in postmenopausal, edentulous women. METHODS: Basing on MCI women were divided into three subgroups differed in the appearance of the mandibular cortex (C1 n=6, C2 n=16, C3 n=8). BMD of the hip (neck-BMD, Ward's-BMD, trochanteric BMD) and mandible (m-BMD) were measured by dual-energy X-ray absorptiometry (DXA). Calcaneus using Achilles (Speed of Sound-SOS (m/s), Broadband Ultrasound Attenuation-BUA [dB/MHz], Stiffness Index-SI [%]) and hand phalanges (amplitude dependent speed of sound-Ad-SoS (m/s)) using DBM Sonic 1200 were assessed by Quantitative Ultrasound (QUS). RESULTS: There were no significant differences between subgroups in parameters measured except for significant differences in m-BMD (P<0.01). Only m-BMD correlated significantly with DXA (r=0.43-0.45, P<0.05) and QUS (r=0.36-0.55, P<0.05) measurements excluding correlations with calcaneal SOS and trochanteric BMD. The ability of the mandibular variables to discriminate between normal and osteopenic/osteoporotic cases was assessed by calculating: specificity (ranging from 31 to 81%), sensitivity (ranging from 21 to 93%), negative and positive predictive values (ranging from 47 to 83% and 40 to 79%, respectively). CONCLUSION: MCI is a simple three-graded classification of changes in the cortex but is not able to distinguish normal and osteopenic/osteoporotic postmenopausal edentulous women. The efficacy of the panoramic-based mandibular indices in diagnosing osteopenia/osteoporosis is low to moderate.

Absorptiometry, Photon↗
PubMed2002

Longitudinal changes in mandibular bone mineral density compared with hip bone mineral density and quantitative ultrasound at calcaneus and hand phalanges.

The aim of this prospective study was to evaluate changes in bone mineral density (BMD) of the mandible (m-BMD) compared with hip BMD and ultrasound parameters of the calcaneus and hand phalanges over 28 months. The study group consisted of 18 post-menopausal edentulous women with no reasons known to affect bone metabolism, such as disease or medication. Each woman had undergone natural menopause. No previous fractures were noted. Measurements were performed at baseline and repeated after 28 months. Bone status was assessed by measuring BMD using dual energy X-ray absorptiometry (DXA) at the mandible and hip and by measuring speed of sound (SOS), broadband ultrasound attenuation (BUA), stiffness index (SI) and amplitude-dependent SOS (Ad-SOS) using quantitative ultrasound at the calcaneus and phalanges of the hand. The coefficient of variation for mandibular measurements was 2.06%. BMD of the mandible, femoral neck and Ward's triangle decreased significantly (-7.54%, -1.2%, -1.97% per year, respectively, p<0.05), whilst BUA, SI and Ad-SOS decreased, but not significantly (-1.1%, -0.47%, -0.08% per year, respectively). Both SOS and BMD of the trochanter had almost the same value without significant differences. The least significant change (LSC), denoting the minimum difference between two successive results in an individual that can be considered to reflect a real change, was calculated. With the exception of changes in m-BMD, no significant changes were observed at any of the sites for the majority of the women (39-89%). 67% of women had a decrease in m-BMD greater than the LSC and 22% had an increase in m-BMD greater than the LSC. Apart from the mandible, other sites showing a large percentage of women with a decrease in BMD greater than the LSC were the Ward's triangle (39%) and the femoral neck (28%). In conclusion, a 28-month longitudinal study of post-menopausal women revealed mandibular bone loss assessed by DXA to be much higher than in other skeletal sites.

Absorptiometry, Photon↗
PubMed2001

Quantitative ultrasound (QUS) at the calcaneus and hand phalanges in Polish healthy postmenopausal women.

In a cross-sectional study, 109 postmenopausal, healthy women, mean age 58.8 years, were studied. The aim of the study was to compare quantitative ultrasound (QUS) performed at two measurement sites of the same persons (correlations between parameters studied, age, and years since menopause (YSM)-related changes, influence of body size). Bone status was established using measurements at the calcaneus by Achilles (Lunar, USA), which measures speed of sound (SOS [m/s], CV% = 0.22%), broadband ultrasound attenuation (BUA [dB/MHz], CV% = 1.8%), stiffness index (SI [%], CV% = 1.3%), and by DBM Sonic 1200 (Igea, Italy), which measures amplitude-dependent speed of sound (Ad-SoS [m/s], CV% = 0.64%) at the hand phalanges. Mean and SD values were: SOS = 1498 +/- 24.8 m/s, BUA = 104.6 +/- 9.4 dB/MHz, SI = 69.2 +/- 12.3%, Ad-SoS = 1879 +/- 90.1 m/s. Age- and YSM-related changes were as follows: age-SOS r = -0.37, p < 0.0001, age-BUA r = -0.33, p < 0.001, age-SI r = -0.36, p < 0.001, age-Ad-SoS r = -0.62, p < 0.00001, YSM-SOS r = -0.27, p < 0.01, YSM-BUA r = -0.32, p < 0.001, YSM-Ad-SoS r = -0.44, p < 0.00001, YSM-SI r = -0.29, p < 0.01. In stepwise, multiple regression analyses of ultrasound parameters on age, YSM, height, and weight, the following equations were obtained: SOS [m/s] = 1564.9 - 1.1 x age [y], r = -0.37, p < 0.0001; BUA [dB/MHz] = 88.7 + 0.28 x weight [kg] - 0.36 x YSM [y], r = -0.51, p < 0.00001; SI [%]) = 79.2 - 0.5 x age [y] + 0.28 x weight [kg], r = -0.47, p < 0.00001; Ad-SoS [m/s] = 2287 to 6.9 x age [y], r = -0.62, p < 0.00001. In conclusion, QUS at the calcaneus and hand phalanges express similar trends in skeletal changes due to aging and the postmenopausal period, although measurements at the phalanges seem to be more sensitive for detecting bone changes, due to faster decrease rate of the Ad-SoS value than calcaneal measurements.

Body Constitution↗