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Biomedical subjects

B E Hagan

Publications and source records attributed to B E Hagan.

5 recordsLinked to original sources
PubMed1989

Torsion of the testis.

Torsion of the testis demands early diagnosis and urgent operative treatment. This study of all patients with torsion of the testis who were admitted to The Prince of Wales Children's Hospital, The Prince of Wales Hospital and The Prince Henry Hospital, Sydney, between 1965 and 1987, reinforces the need for urgent diagnosis and treatment and evaluates the diagnostic value of the sign of the contralateral horizontal testis. One hundred and thirty-one patients were studied; the majority was in the adolescent age-group. If operation were delayed beyond 24 hours without spontaneous relief of the symptoms or manipulative detorsion being performed, then at follow-up 5.5% of testes were normal; however, if operation were performed within 24 hours of the onset of symptoms, 90% of testes were normal at follow-up. In all cases in which it was sought, the sign of the contralateral horizontal testis was found, which confirms the bilaterality of the condition and that a high investment of the tunica vaginalis predisposes to torsion of the testis.

Adolescent↗
PubMed1980

The mathematical transformation of growth and form--I:Transferring the wave - particle duality from physics to biology and proposing wave interaction as a key determinant of biological structure.

Just as the material units of existence, atoms and basic particles, can be viewed as waves or particles, depending on the observational frame chosen by the physicist, so also can biochemical macro-molecules, the units of biological existence, be viewed as waves or particles by the biologist. It is proposed that the flux of different waveforms which floods biological systems provides an interference pattern, whose energetic distribution forms a scaffold for the construction of biological forms. In this way the biological whole becomes the Fourier transform of the parts and histological pattern becomes the determinant of macroscopic form. Evidence is adduced suggesting that biological forms follow the energy patterns laid down by the environment. It is proposed that the ability of bipolymers to re-radiate coherent waveforms derived from the environment, has given evolved systems the autonomy which has allowed a free and prolific evolution. This coherent illumination can be analysed by Fourier methods and this shows that the results are peculiarly appropriate for biological systems. The Gaussian waveform is all-important and may explain the influence of homogeneous and heterogeneous DNA in cell surface kinetics, hybridisation and carcinogenesis.

Action Potentials↗
PubMed1978

Sperm basic proteins in cervical carcinogenesis: Correlation with socioeconomic class.

Two types of basic protein, a histone and a protamine, were separated from single ejaculates of human sperm and a ratio between their contents in a given number of sperm established. The ratio varied widely in different males and correlated with ranking by social class: the lower the social class, the greater the proportion of protamine. Statistically similar correlations link social class with the incidence of venereal disease and the incidence of in-situ carcinoma of the cervix, both of which are epidemiological variables in squamous cervical cancer. The basic proteins of the sperm head, especially the protamines, may thus also have a role in the aetiology of squamous cervical cancer.

Carcinogens↗