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Sperm basic proteins in cervical carcinogenesis: Correlation with socioeconomic class.

B L Reid·P W French·A Singer·B E Hagan·M Coppleson
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Abstract

Two types of basic protein, a histone and a protamine, were separated from single ejaculates of human sperm and a ratio between their contents in a given number of sperm established. The ratio varied widely in different males and correlated with ranking by social class: the lower the social class, the greater the proportion of protamine. Statistically similar correlations link social class with the incidence of venereal disease and the incidence of in-situ carcinoma of the cervix, both of which are epidemiological variables in squamous cervical cancer. The basic proteins of the sperm head, especially the protamines, may thus also have a role in the aetiology of squamous cervical cancer.

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CarcinogensCarcinoma in SituCarcinoma, Squamous CellFemaleHistonesHumansMaleOccupationsProtaminesSocial ClassSperm HeadSpermatozoaUterine Cervical NeoplasmsBiologyCancerCervical Cancer--etiologyDiseasesEconomic FactorsExaminations And DiagnosesGenitaliaGerm CellsInfectionsLaboratory Examinations And DiagnosesLaboratory ProceduresNeoplasmsPhysiologyReproductive Tract InfectionsSexually Transmitted DiseasesSocioeconomic FactorsSocioeconomic StatusSpermatozoa--analysisUrogenital SystemComparative StudyJournal Article

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B L Reid, P W French, A Singer, B E Hagan, M Coppleson. 1978-07-08. Sperm basic proteins in cervical carcinogenesis: Correlation with socioeconomic class.. https://doi.org/10.1016/s0140-6736(78)91378-8

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