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Biomedical subjects

B Friberg

Publications and source records attributed to B Friberg.

At least 37 records · Page 2Linked to original sources
PubMed1997

Mk II: the self-tapping Brånemark implant: 5-year results of a prospective 3-center study.

The 5-year result of a prospective 3-center study is presented, comprising 103 patients with 288 Mk II self-tapping and 275 standard implants of the Brånemark System. Out of 363 mandibular and 200 maxillary fixtures, one Mk II was lost of the lower jaw and 13 of each implant type failed in maxillae during the study period. Cumulative prosthesis stability was 97%. Five patients accounted for more than 85% of the fixture losses. Marginal bone resorption was similar for both implant designs. Apart from the implant failures and one patient exhibiting disturbed nerve sensation of the mental nerve, no major complications were encountered. Overall, this study revealed equal cumulative success rates for standard and Mk II implants after 5 years of observation. Mandibular implants exhibited greater success rates (100%) for both tested implant types compared to maxillary implants (87%).

Adult↗
PubMed1997

A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines anal squamous cell carcinomas.

Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours. Infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regarding recurrent chromosomal aberrations in this subgroup of squamous cell carcinomas. We have applied comparative genomic hybridization to identify chromosomal gains and losses in 23 cases of anal carcinomas. A non-random copy number increase of chromosomes 17 and 19, and chromosome arm 3q was observed. Consistent losses were mapped to chromosome arms 4p, 11q, 13q and 18q. A majority of the tumours were aneuploid, and most of them showed increased proliferative activity as determined by staining for Ki-67 antigen. p53 expression was low or undetectable, and expression of p21/WAF-1 was increased in most tumours. Sixteen cancers were satisfactorily tested for the presence of HPV by consensus L1-primer polymerase chain reaction; nine were HPV positive, of which eight were positive for HPV 16.

Adult↗
PubMed1997

ECG changes in epilepsy patients.

OBJECTIVES: To investigate the frequency of ECG abnormalities suggestive of myocardial ischaemia in patients with severe drug resistant epilepsy and without any indication of previous cardiac disease, assuming that these changes may be of significance for the group of epileptic patients with sudden unexpected death. MATERIAL AND METHODS: Twelve patients with medically intractable epilepsy were investigated with simultaneous long ECG and EEG recordings while attending either epilepsy surgery investigational procedures or the investigational programme for diagnostic purposes, and one while having an episode of status epilepticus. RESULTS: The ECG recording failed in 1 patient. This patient had chest pain and minor yet morphologically conspicuous changes in the ECG, suggestive of myocardial infarction. He died in heart arrest. Eight epilepsy patients had episodes of ST segment depression in the ECG, many of which coincided with video- and EEG documented epileptic seizures. Two patients experiencing simple partial seizures and 1 patient experiencing absence seizures had no ST segment depressions in the ECG. One patient had an episode of status epilepticus secondary to brain damage and no ST segment deviation was seen during the ECG recording which continued until 3 h before the patient died. CONCLUSION: Patients with severe drug resistant epilepsy have episodes of ST segment changes, some of which are closely related to epileptic seizures. Further studies are needed to confirm the present results and to investigate the nature of these changes and document the effect of prophylactic treatment with cardioactive drugs to reduce the risk of sudden death.

Adolescent↗
PubMed1996

Inefficiency of upward displacement operating theatre ventilation.

A new thermally based ventilation system ('Floormaster') with inlet of cool clean air at floor level, and evacuation at the ceiling of the air warmed by activity in the room (upward displacement ventilation, 17 air changes/h) was compared with a standard positive pressure (plenum) ventilation system with air supply through an inclined perforated screen along one wall at the ceiling and evacuation at floor level (conventional turbulent or mixing system, 16 air changes/h). The study was made during rigidly standardized sham operations (N = 20) performed in the same operating room by a six-member team wearing non-woven disposable or cotton clothing. In general the upward displacement system removed dust particles too small to carry bacteria (0.16-<0.3 microm, 0.001<P<0.01) more efficiently than the conventional system. However, the displacement system also yielded two to threefold higher air and surface bacterial counts in areas important for surgical asepsis (wound area, instrument table) especially with regard to bacterial sedimentation (0.001<P<0.05). The major shortcoming of the displacement system was insufficient elimination of the larger bacteria-carrying particles. The type of clothing worn by the members of the team did not influence the overall results. We conclude that an upward displacement system will lead to increased counts of airborne and sedimenting bacteria and thus increase the risk of postoperative infection in comparison with conventional operating room ventilation systems.

Air Microbiology↗
PubMed1996

Intelligence and behaviour in children born after in-vitro fertilization treatment.

This study is the first to examine a large group of children born after in-vitro fertilization (IVF) who were old enough at the time of the investigation to make it possible to draw conclusions about the outcome. The aim of the study was to assess the cognitive, behavioural and social development of the children. The study comprised 99 IVF children, 33-85 months of age, from the University Hospitals of Lund and Malmö, Sweden. The children's development was assessed with the Griffiths' scales of mental development. The children's behaviour was delineated through semi-structured interviews with their mothers, covering 50 different behaviours. The mothers also filled in Achenbach's Child Behaviour Checklist (CBCL). All children were examined by a paediatric neurologist. The results were compared to Swedish population groups. Of the children born, 66% were singletons, 22% were twins, 12% were triplets and 28% were born prematurely in gestational weeks 32-36. The cognitive development of the IVF children was excellent, and their behaviour was normal when compared with two Swedish population groups. Our conclusion was that the development, behaviour and social adaptation of the children was very satisfactory.

Adult↗
PubMed1996

Endometrial destruction by hyperthermia--a possible treatment of menorrhagia. An experimental study.

BACKGROUND: Treatment of menorrhagia by heat-destruction of the endometrium, intended to be an alternative to hysterectomy, was investigated in an experimental study. METHOD: A specially designed catheter (CavatermTM) with a silicone balloon containing a self-regulating containing heating element is inserted into the uterus, filled with glycine to a pressure of around 180 mmHg and heated to about 75 degrees C. We investigated the treatment effect in vitro in five extirpated uteri (series A) and in vivo in three patients treated peroperatively just before hysterectomy, temperatures being monitored in the surrounding tissues (series B). In both series we monitored the following variables: heating-power, balloon-pressure, temperature of the heating element (around 85 degrees C) and the temperatures at five locations from top to bottom of the balloon surface. RESULTS: After 30 min in vitro treatment at 75 degrees C, the endometrium was partly destructed, and condensed. Histological examination showed smooth muscle cells to be destroyed to a depth of 2-5 mm close to the endometrium. With in vivo treatment for 30 min at a heating power of about 20 W (resulting in balloon surface temperatures of 58-65 degrees C), the increases in temperature of the surrounding tissue were too small to measure accurately (+/-1 degree C). Histological examination showed destruction of cells in the corpus uteri to a maximum depth of 8 mm. CONCLUSION: Findings in in vitro and in vivo experiments suggest that 30 min heating of the endometrium to 58-65 degrees C with an intrauterine silicone balloon filled with a liquid to a pressure of 180 mmHg exerts therapeutic effects on both endometrium and uterine cavity smooth muscle cells without damage to surrounding tissues.

Catheterization↗
PubMed1996

Thromboprophylaxis with a low molecular weight heparin (tinzaparin) in emergency abdominal surgery. A double-blind multicenter trial.

In this prospective randomized double-blind study the thromboprophylactic effect of postoperative low molecular weight heparin (tinzaparin) was compared with placebo in 80 patients undergoing emergency abdominal surgery. The fibrinogen uptake test was used but because of withdrawal of the labelled fibrinogen from the market the calculated number of patients was not reached. However, this is one of the few studies in emergency abdominal surgery we thought it important to report. The frequency of deep vein thrombosis was reduced with prophylaxis from 22% (95% conf. intervall 11-38%) to 8% (2-21%), a risk reduction of 65%, which is however not significant. Together with data from the few previously published studies it can be concluded that patients undergoing emergency abdominal surgery seem to benefit from prophylaxis, which should be instituted either before operation or at latest 24 hours after. The exact prophylactic relation between pre- and post-operative start would, however, require a separate, randomized study.

Abdomen↗
PubMed1995

Evaluation of bone density using cutting resistance measurements and microradiography: an in vitro study in pig ribs.

A method using cutting resistance measurements during low-speed threading for identification of various bone densities has been evaluated with regard to its precision and potential. Pig ribs were used as test samples. Differing hand pressure, minor deviation (5 degrees) from a vertical tapping direction and individual threading did not reveal any significant differences in cutting resistance values. After implants were inserted into the threaded canals, the total bone as well as trabecular and compact bone areas surrounding the implants were calculated via a computer program and using microradiographs of the bone test samples. The outcome of the cutting resistance measurements was compared with that of the microradiographic technique, and good agreement was observed between the two procedures in the ability to identify bone density. Therefore, cutting resistance measurements may in the future also be used to clinically identify bone qualities in jaws.

Animals↗
PubMed1995

Identification of bone quality in conjunction with insertion of titanium implants. A pilot study in jaw autopsy specimens.

Ten autopsy jaw specimens (6 mandibles, 4 maxillae) were used for cutting resistance measurements during low-speed threading. Overall, 31 sites were analyzed where implants were inserted into threaded canals. Bone area measurements were performed around the implants as described previously. The cutting resistance values together with the total bone area values were found to be higher in mandibles than in maxillae, and a tendency towards higher values was seen in incisor regions compared with premolar regions. Furthermore, an intraindividual comparison between the true cutting resistance and the bone density values of prepared sites showed a statistically significant correlation. The method with cutting resistance measurements for evaluation of bone quality seems therefore to be reliable, at least when used in human autopsy jaw bone specimens.

Aged↗
PubMed1995

[Osseointegrated implants in adolescents. A three year study].

In 15 adolescents (age 13.2 to 19.4 years) in the late dental stage implants (n = 27) were chosen to replace missing teeth due to congenital absence or trauma. The patients were followed for at least 3 years. No fixture losses occurred. Only minor loss of bone support at the fixture was observed, while adjacent tooth surfaces showed some loss. Infra-occlusion of the implant restorations was noticed in patients with residual craniofacial growth. Thus, the dental and skeletal maturation, and not the chronological age, must be taken into account to avoid infra-occlusion. Furthermore it is important to gain enough space for the fixture in the mesio-distal direction in order to avoid the risk of marginal bone loss at teeth adjacent to the implants.

Adolescent↗
PubMed1995

Bone augmentation at single-tooth implants using mandibular grafts: a one-stage surgical procedure.

The surgical procedure of using a titanium implant in combination with a mandibular bone graft for a single-tooth reconstruction is presented. The donor bone was taken from the vestibular base, close to the symphysis of the mandible. Patients who were missing a maxillary incisor or canine tooth, and exhibiting a loss of supporting bone in the area, were found suitable for the technique.

Alveolar Ridge Augmentation↗
PubMed1994

The use of a new bioresorbable barrier for guided bone regeneration in connection with implant installation. Case reports.

This report presents 4 cases with 6 implant exposures after the installation of Brånemark System implants which called for treatment applying the guided bone regeneration technique. A bioresorbable barrier (GUIDOR Matrix Barrier) was used to cover the defects, 4 defects with and 2 without the support of autologous bone chips. Complete bone filling was found in 4 (2 without and 2 with bone chips) and partial filling in 2 (with bone chips) of the treated defects, as registered at the abutment connection 6-7 months after surgery. Besides its ability to serve as a barrier for guided bone regeneration, it was found that the matrix barrier had the following properties; biocompatibility observed as uneventful tissue healing, malleability facilitating the clinical handling and ability to be resorbed within 6 to 7 months, as evaluated by clinical inspection. The observations of the present case reports indicate that the tested barrier may be used for guided bone regeneration in connection with implant installation. It is advisable, however, to use a supporting material to prevent barrier collapse, although bone regeneration can be achieved in certain situations without such material if the defect morphology is favourable.

Aged↗
PubMed1994

Osseointegrated implants in adolescents. An alternative in replacing missing teeth?

In 15 adolescents (13 years 2 months-19 years 4 months) in the late dental stage, Brånemark implants (n = 27) were chosen to replace missing teeth due to congenital absence or trauma. The patients were followed for at least 3 years, at yearly intervals, biometrically and radiographically. No fixture losses occurred. Only minor loss of bone support at the fixtures was observed, while adjacent tooth surfaces showed some loss in some cases. Infra-occlusion of the implant restorations was noticed in patients with residual craniofacial growth. Thus, the dental and skeletal maturation, and not the chronological age of the patient, must be taken into consideration to avoid infra-occlusion of the fixture crown. Furthermore, it is important to gain enough space for the fixture in the mesio-distal direction, to avoid the risk of marginal bone loss at teeth that are adjacent to it.

Adolescent↗
PubMed1994

Tubal patency studied by ultrasonography. A pilot study.

Transvaginal hysterosalpingoultrasonography (HSUG) was performed using a uterine cannula and Ringer's solution (Kabi Baxter) as a contrast agent in 14 women consulting for infertility. The results were compared with those of chromopertubation at laparoscopy/laparotomy. With HSUG, the uterine cavity was always well visualized, though it was more difficult to evaluate tubal status. As compared with those of the other methods, HSUG findings manifested total agreement in 50% of cases, total disagreement in 22%, and partial agreement in the remaining 28%. The method was well tolerated by the women studied, and six out of nine women who had previously undergone hysterosalpingography (HSG) found HSUG to cause less discomfort. Thus, the findings suggest that HSUG might prove useful as a means of ascertaining tubal status at an early stage in infertility evaluations.

Fallopian Tube Patency Tests↗
PubMed1994

Treatment with dental implants in patients with severe osteoporosis: a case report.

The case report of a woman with severe osteoporosis who was treated with dental implants is presented. Polyarthritis was diagnosed in 1955, and a corticosteroid medication treatment was started in 1960. During the years, the patient has undergone multiple joint surgeries. Dental implants were inserted in the maxilla in 1987 and in the mandible in 1988. Due to a compression of the spine, the patient lost 12 cm in body height between 1991 and 1993; a spontaneous femur fracture was diagnosed in December 1992. However, the arch bone has been stable; the 6- and 5-year follow-up results of the maxillary and mandibular implants, respectively, are presented.

Arthritis↗
PubMed1993

Radiation treatment of epidermoid cancer of the anus.

PURPOSE: The purpose of this study was to evaluate our treatment results of anal cancer. METHODS AND MATERIALS: During the years 1985-1990, 82 patients with invasive epidermoid and cancer were referred to the Department of Oncology at Södersjukhuset. In 76 cases irradiation was used in the primary therapy, and in 43 cases bleomycin was administered concurrently. Fifteen of these tumors were situated in the perianus and 61 in the anal canal. Probability of survival, recurrence, and preservation of anal sphincter was analyzed according to Kaplan-Meier. Cox multivariate analysis was used in studying potential determinants of risk for treatment failure. RESULTS: Tumor-specific survival at 5 years was 71% for both anal canal and perianal cancer. Analyses with regard to cancer of the anal canal indicated that T4 tumors had significantly worse prognosis than those in stages T1-3. Overall survival was 73% and 79% at 5 years for T1 and T2 tumors and 73% and 18% at 4 years for T3 and T4 tumors. Corresponding figures for tumor specific survival were 79%, 79%, 82%, and 31%. Eighty-five percent of patients with T1 tumors, had a preserved anal sphincter after 4 years. For T2 and T3 tumors the corresponding figures were 62% and 60%. Also the multivariate analyses showed stage T4 to be a strong negative prognostic determinant. There was no firm evidence of a positive effect of bleomycin on the treatment results, but it increased the acute radiation toxicity. CONCLUSION: Primary radiotherapy of anal cancer yielded a high probability of survival, but in many cases sphincter amputation have been necessary. The role of bleomycin appears questionable.

Aged↗