PubMed Health⌕ Search

Biomedical subjects

B Günther

Publications and source records attributed to B Günther.

At least 91 records · Page 5Linked to original sources
PubMed1983

Experimental hemorrhagic shock in dogs: standardization.

The purpose of the present study was to design a standardized model of hemorrhagic shock in dogs as a prerequisite for future studies on the pathogenesis of this syndrome. Hemorrhagic shock was induced in 86 mongrel dogs submitted to a systemic hypotension of 45 mm Hg by means of a constant pressure reservoir procedure. The following blood volumes (ml/kg) were measured during the evolution of shock: (1) initial bleeding volume, (2) secondary bleeding volume, (3) maximum bleeding volume, (4) automatic reinfusion volume, and (5) duration of the hypotensive period (min). The corresponding mortalities were submitted to a statistical analysis which yielded the following conclusions: (a) the initial, secondary, and maximum bleeding volumes do not correlate with mortality, (b) the duration of the hypotensive period is of only relative importance, and (c) the automatic reinfusion volumes shows a high degree correlation with the fatal outcome.

Animals↗
PubMed1983

Substrate balances across the forearm during the early postoperative period.

The substrate metabolism of skeletal muscle has been studied by the forearm technique in 23 patients after abdominal operation. The data were compared to those of 55 healthy volunteers after an overnight fast. While the uptake of glucose into forearm muscle tissue was increased in relation to its elevated arterial concentration, its rate of oxidation was clearly reduced and the muscle extraction of ketone bodies was increased. Simultaneously, the production of lactate was doubled and the output of glycerol and alanine significantly enhanced. From these data one may conclude that 3 hours after abdominal surgery the energy requirements of skeletal muscle tissue are adequately met by the substrates provided that glucose sparing occurs in association with a rising arterial concentration of KB, and that the release of alanine is accelerated in spite of abundant caloric supply.

Journal Article↗
PubMed1983

[Peripheral venous hypocaloric nutrition following large abdominal interventions].

In a pilot study with 10 patients after major abdominal operations like gastrectomy or esophagectomy a postoperative hypocaloric peripheral-venous nutrition was performed. Prerequisite was a good nutritional status established by anthropometric measurements and determinations of visceral proteins and an uneventful operation of less than 4 hours duration and max. up to 1000 cc blood loss. After 10 days of infusion only body weight and the skin falt thickness were reduced. During the peripheral nutrition insulin, glucose, free fatty acids and beta-hydroxybutyrate showed only minor movements. Only on the 4th postoperative day the urinary-N-excretion increased over 16 g/24 h. The study demonstrates that hypocaloric peripheral-venous nutrition under certain preconditions will be an alternative to standard nutrition.

Adult↗
PubMed1982

[Postoperative changes in energy metabolism].

New methods give us a growing insight into energy expenditure and substrate flow in postoperative stress. Better knowledge of pathophysiology may lead to a more reasonable administration of carbohydrate and fat calories. Thus side effects of postoperative nutrition may be prevented.

Blood Glucose↗
PubMed1979

[Case contribution to the question of side effects in the dipyridamol test].

Report on a case with disturbance of the cardiac rhythm (atrioventricular dissociation with ventricular extrasystoles) in connection with a dipyridamol test which regressed under therapy with euphyllin. This observation supports the demand of a continuous control of the ECG when the test is performed.

Aged↗
PubMed1979

[Not Available].

Explore the source record for details and available documents.

France↗
PubMed1978

[Improvement of pathological glucose tolerance by bradykinin in diabetics and in surgical patients (author's transl)].

Intravenous glucose tolerance tests (GTT) were performed in 13 metabolically healthy patients at the first and second day after abdominal surgery. GTT were carried out during an additional infusion of bradykinin (BK) (80 microgram/h) in six of these patients at the first day (group A) and in seven patients at the second day (group B). Furthermore, GTT were performed in six patients with chemical diabetes with and without BK-infusion. In addition, the effect of BK on blood glucose concentration in the postabsorptive state was investigated in nine maturity onset diabetics and in five healthy volunteers. As a control, another nine diabetics received physiological saline. In both groups of surgical patients BK improved glucose tolerance (k-values: group A without BK 1.03 +/- 0.12, with BK 1.31 +/- 0.07; group B without BK 0.85 +/- 0.18, with BK 1.25 +/- 0.21). This was also true in chemical diabetics (without BK 0.81 +/- 0.03, with BK 1.08 +/- 0.04). While BK did not change blood glucose concentration in healthy volunteers, it reduced that of diabetics by 12.2 +/- 1.4% continuously during 100 min. No spontaneous drop of blood glucose was observed in diabetics receiving saline. These results are in good accord with the present view that kinins may play a role within the regulation of carbohydrate metabolism.

Blood Glucose↗
PubMed1978

[Theory and critical aspects of the so-called steal effect of coronary dilators of the dipyridamole type].

The stenocardias appearing in the dipyridamol test are explained by the hypothesis of a steal effect. This notion is, concerning its contents, to be demarcated against other regulatory processes. With the help of a simple model can be made clear that the thesis of a steal effect stands in contradiction to haemodynamic basic conceptions and cannot be used for the explanation of the paradoxical effect of dipyridamol.

Blood Circulation↗