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B Hagmar

Publications and source records attributed to B Hagmar.

99 records · Page 6Linked to original sources
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Comparison of development of serum antibodies to HPV16 and HPV33 and acquisition of cervical HPV DNA among sexually experienced and virginal young girls. A longitudinal cohort study.

OBJECTIVES: To study the importance of sexual activity and early coitus debut on the risk for acquiring infection with human papillomavirus (HPV) type 16 or 33. STUDY DESIGN: Ninety-eight healthy adolescent girls were followed up with consecutive interviews and donations of serum and cervical brush samples during 2 years. RESULTS: Fourteen percent of sexually experienced girls had serum immunoglobulin G to HPV16 and/or HPV33 capsids, and 14% also had cervical HPV16 or HPV33 DNA. Seropositivity for HPV correlated with detection of cervical HPV DNA. None of the 36 girls without coital experience was seropositive or harbored cervical HPV DNA. Seropositivity for HPV was correlated strongly with the number of sexual partners: Odds ratio for > 1 sexual partner was 16.3 (P < 0.001), and for early coitus debut (younger than 17 years of age), it was 14.3 (P < 0.002). CONCLUSIONS: Both HPV serology and HPV DNA testing indicated that the number of sexual partners and earliness of coitus debut determined the risk for acquiring HPV infection and that nonsexually transmitted infections are rare or nonexistent among adolescent girls.

Adolescent↗
PubMedDate not supplied

The comedo subtype of intraductal carcinoma. Cytologic characteristics.

Smears from 10 intraductal carcinomas of the comedo type without microinfiltration were compared with smears from 10 similar tumors with suspected or proven microinfiltration and smears from 10 invasive comedo carcinomas. Microinvasive tumors could not be separated from purely intraductal cases unless tumor cell infiltration in mammary fat was seen in the smear. The tumor cells in most of the intraductal cases were shed in cohesive groups and clusters, lying in necrotic cellular debris and with few or no scattered, single, dissociated tumor cells. Smears from invasive comedo carcinomas invariably showed tumor cell clusters and scattered, single, dissociated tumor cells, often with atypia in excess of what was seen in the intraductal cases. Also, in most cases the invasive tumors did not show a background of necrotic cellular debris.

Adult↗
PubMedDate not supplied

Myxofibrosarcoma: a correlative cytologic and histologic study of 13 cases examined by fine needle aspiration cytology.

A correlative cytologic and histologic study of 13 myxofibrosarcomas is presented. The myxofibrosarcomas were grouped histologically into four grades (I to IV) according to the degree of cellularity, atypica and prevalence of mitotic figures. Cytologically, the neoplasms exhibited two types of malignant cells: an elongated, spindle-shaped, fibroblast-like cell and a larger, histocyte-like cell, often embedded in myxoid material. Some aspirates contained small capillary-like fragments. The degree of cellular and nuclear polymorphism and the quantitative distribution between the two types of cells in the different grades corresponded to the histologic classification. The differential diagnosis between myxofibrosarcoma and other myxoid soft tissue neoplasms is discussed. Staining the aspirated material with Alcian blue at different pHs helps to distinguish between myxomatous mesenchymal neoplasms containing nonsulphated glucosaminoglycans, such as myxofibrosarcoma, and those containing sulphated ones, such as myxoid chondrosarcoma and chordoma.

Adult↗
PubMedDate not supplied

A one-year audit of fine needle aspiration cytology of breast lesions. Factors affecting adequacy and a review of delayed carcinoma diagnoses.

OBJECTIVE: To compare the rate of inadequate specimens in a triple-diagnosis breast clinic with that of specimens taken by clinicians. STUDY DESIGN: Breast aspirates obtained in 1993, 2,923 specimens, were reviewed. Of these, 1,515 (51.9%) were taken in a specialist clinic with a triple approach (clinical examination, imaging and aspiration cytology). Palpable lesions were aspirated by a cytopathologist and nonpalpable lesions by a cytopathologist and radiologist in cooperation using imaging techniques. The rate of inadequate specimens was determined and compared with the rate of the remaining specimens, which were sent to the laboratory by clinicians. RESULTS: In the breast clinic, the inadequacy rate was 3.8% (n = 58). The inadequacy rate for the 1,408 mailed breast aspirates was 14.8% (n = 209). A cancer diagnosis was recorded in 13.5% (n = 395). Six carcinomas were diagnosed late because of inadequate specimens. CONCLUSION: The inadequacy rate was lower in cytology samples taken in a specialized breast clinic than in samples mailed to the laboratory by clinicians. In order to increase the detection rate of malignancies, clinicians performing fine needle aspiration should be trained in the aspiration technique and smear preparation.

Biopsy, Needle↗
PubMedDate not supplied

Assessment of fine needle aspiration cytology and histopathology for diagnosing male breast masses.

OBJECTIVE: To investigate the diagnostic accuracy of fine needle aspiration cytology (FNAC) from breast lesions in males and to determine the frequency of benign versus malignant histopathologic diagnoses in surgical biopsies from male breast lesions. STUDY DESIGN: FNAC specimens from breast lesions taken from 241 males over 8.5 years were divided into four subgroups according to the original cytologic diagnoses. Diagnostic accuracy was verified with the Norwegian Cancer Registry. Ten years' worth of material from 809 surgical biopsies from male breast lesions was subgrouped according to the original histopathologic diagnoses. RESULTS: Of the 809 surgical biopsies, 779 (96.3%) were benign lesions. Of the 241 fine needle aspirates, 27 (11.2%) were unsatisfactory for cytologic diagnosis. Of the remaining 214 cases, 200 benign cytologic diagnoses were confirmed at follow-up. Thus, there were no false negative cytologic diagnoses; eight malignant diagnoses were confirmed by later histopathologic examination of the surgical biopsy. CONCLUSION: To reduce the high rate of surgical biopsies of benign male breast masses, we conclude that FNAC should be performed as a standard procedure in the clinical evaluation of male breast lesions.

Adolescent↗
PubMedDate not supplied

Human papillomavirus in cell samples from Stockholm Gynecologic Health Screening.

We compared the results of cytologic screening of 500 women in the Stockholm Gynecologic Health Control with human papillomavirus (HPV) detection by polymerase chain reaction (PCR) and in situ hybridization (ISH). There were two main age groups, one 30 years and younger and the other 40 years and older. There were relatively more women with HPV infection in the younger group than in the older one (15.7% as compared to 11.1%), but the difference was not significant in our material. Most cases (8/12) with cytologic atypia were HPV positive by PCR. HPV type 16 was most common, followed by types 31 and 18. HPV of unknown types was detected in 43.7% of HPV-positive cases. There was excellent agreement between PCR and ISH in detecting and typing HPV.

Adult↗
PubMedDate not supplied

Diagnostic accuracy of fine needle aspiration cytology in pancreatic lesions. A review of 77 cases.

Fine needle aspiration cytologic specimens from pancreatic lesions in 77 patients were blindly reviewed. The patients were divided into two subgroups: group A included 19 patients without malignancy of the pancreas, and group B included 58 patients with confirmed malignancy (primary or secondary) of the pancreas. The original cytologic diagnoses in both groups were plotted against the respective reevaluated cytologic diagnoses. In group A there were no false-positive cytologic diagnoses, neither originally nor on reevaluation. In group B, among nine cases originally diagnosed as "benign cells," there were two cases diagnosed as malignant on reevaluation, while in the remaining seven cases malignant cells could not be found on reevaluation. In 11 cases in group B the cell material was considered insufficient for cytologic diagnosis, both originally and on reevaluation. In 34 of the 58 cases (58.6%) in group B a conclusive cytologic diagnosis of malignancy was made both in the original cytologic reports and on reevaluation. In this series, sampling errors accounted for most false-negative cytologic diagnoses. The specificity in our series was 100%. The demonstrated sensitivity was 59% initially and 62% on reevaluation.

Adult↗