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Biomedical subjects

B Jazdzewski

Publications and source records attributed to B Jazdzewski.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Plasma and erythrocyte lipids in amyotrophic lateral sclerosis].

The authors studied the changes of lipids of the plasma and erythrocytes in 10 cases of amyotrophic lateral sclerosis and in 20 controls matched for age. In the plasma of patients with ALS increased levels were found of free cholesterol and triglycerides, with a decrease of lysophosphatidylcholine. The values of lipid fractions in erythrocyte membranes were not significantly different between these groups, with exception of increased level of total phospholipids (including phosphatidylethanolamine) and cholesterol.

Adult↗
PubMedDate not supplied

[Changes in lipid composition of blood serum and erythrocytes in patients with transient focal cerebral ischemia].

Determinations of the lipid pattern of the serum and erythrocytes were carried out in 27 patients with transient focal cerebral ischaemia and in 20 healthy subjects. In the group of patients with transient focal cerebral ischaemia the levels of total lipids, phospholipids and cholesterol were higher in the serum and erythrocytes than in healthy controls.

Adult↗
PubMedDate not supplied

[Comparative studies on the lipid content of the cerebrospinal fluid and serum lipoprotein fractions in patients with discopathic changes].

The reported investigations were carried out in 12 subjects with low back pains caused by lumbar discopathy. The studied material were cerebrospinal fluid samples obtained during lumbar tap and blood obtained from the antecubital vein. In the fluid, serum and lipoprotein fractions the concentrations of cholesterol, triglycerides and phospholipids were determined. It was found that the concentration of the lipids determined in the cerebrospinal fluid in patients with discopathy was not different from that demonstrated in healthy subjects. The lipid content of the fluid differed significantly from that of the serum but was very similar to the composition of lipids in the high density lipoprotein fraction (HDL). The summed up concentration of cholesterol, triglycerides and phospholipids was about 170 times lower than that in the HDL fraction.

Adult↗
PubMedDate not supplied

Plasma biochemical changes and acid-base equilibrium changes in capillary blood nursing frequency repeated submaximal physical exercise in untrained subjects.

The reported investigations were carried out on healthy men aged 20--22 years in two groups: group A of 11 subjects and group B of 12 subjects. Both groups performed five times at 50-minute intervals submaximal physical exercise during 10 minutes on a Monark ergometer. Group A performed the exercise at a steady heart rate of about 170/min with variable workload, while group B performed it at a steady workload but changing heart rate. At rest and after each exercise the plasma concentrations of free fatty acids, glucose and amino-acid nitrogen were determined in both groups, and changes in the parameters of acid-base equilibrium were studied in capillary blood. It was found that after each consecutive exercise the concentration of free fatty acids (FFA) increased ever more and the rise of the haematocrit index decreased. Glucose concentration decreased after the 1st, 2nd and 3rd exercises, but increased after the remaining two exercises. The concentration of amino-acid nitrogen showed an increasing tendency after exercise in both groups. The changes in the acid-base equilibrium, that is its shifting towards metabolic acidosis were greatest after the first exercise. In group A each consecutive exercise caused less pronounced disturbances of acid-base equilibrium. In group B the intensity of metabolic acidosis was lower in consecutive exercises in relation to the first one, but it was greater than in group A.

Acid-Base Equilibrium↗
PubMedDate not supplied

Changes in the concentrations of certain biochemical parameters in the peripheral blood during exercise and restitution after bloodletting.

The reported investigations were carried out in 18 men aged 19 to 23 years in whom 400 ml of whole blood was removed. On the day before bloodletting, one hour and 24 hours after it the studied men carried out a 10 minute exercise on a Monark cycle ergometer at a workload raising the heart rate to 170/min. Before the exercise, immediately after it and in the 30th minute of restitution venous blood samples were taken for determinations of the concentrations of total protein, albumins, free fatty acids, glucose, lactate and pyruvate, and the activity of lactic dehydrogenase, alanine aminotransferase and aspartate aminotransferase. During that time the acid-base equilibrium was determined in capillary blood. After bloodletting the concentrations of albumins, total protein and free fatty acids were decreased parallelly to haematocrit value decrease (p less than 0.05) and glucose concentration increased slightly (p less than 0.05). Enzyme activity was decreased slightly (p greater than 0.05). The partial oxygen pressure decreased, that of carbon dioxide increased, and hydrogen ion concentration rose. These changes were more pronounced after 24 hours than 1 hour after bloodletting. After submaximal exercise and in the 30th minute of restitution as well as 1 and 24 hours after bloodletting the changes in the concentrations of the biochemical parameters, enzyme activity and acid-base equilibrium were similar as after bloodletting.

Acid-Base Equilibrium↗
PubMedDate not supplied

Furosemide effect on gastric basal secretion during exercise and postexercise restitution in healthy subjects.

The purpose of this work was determination of furosemide effect on basal gastric secretion during exercise and postexercise restitution in 8 healthy men aged 22-25 years. The investigations were performed three times determining each time the basal acid output during three successive hours. In the first test the determinations were done during one hour rest, then after intravenous furosemide administration 2 mg/kg, and again between 60 and 120 minutes after the injection. In the second test BAO was determined at rest, during one-hour exercise, and during restitution. In the third test the determinations were done at rest, during exercise preceded by furosemide injection as in the first test, and during one hour of post-exercise restitution. The exercise on a Monark cycle ergometer was, on the average, 275 210 +/- 12 500 J in the second test and 284 870 +/- 14 480 J in the third test. Furosemide caused a statistically significant decrease of BAO at rest (p less than 0.02) and during exercise (p less than 0.01), this was due to a significant reduction in gastric juice volume (p less than 0.001) and in the second hour of furosemide action also to a decrease of HCI concentration (p less than 0.05). Decreased excretion of electrolytes by the gastric mucosa was proportional to changes in gastric juice volume. The 24-hour urinary excretion of sodium, potassium and chlorides increased after furosemide in the first test (p less than 0.001), and in the third test (p less than 0.02).

Adult↗