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Biomedical subjects

B Kumar

Publications and source records attributed to B Kumar.

At least 127 records · Page 7Linked to original sources
PubMed1982

Hemodialysis therapy for psoriasis.

Twenty-five patients with extensive plaque psoriasis resistant to conventional treatment were evaluated for study of the effects of dialytic therapy on the skin lesions. Twenty patients were dialyzed twice a week for six hours each time with a 1.0 m2 Cuprophan membrane dialyzer. Eighteen patients responded to this therapy with regression of skin lesions. Twelve of them have not developed recurrence of lesions during a followup period extending from 6 to 27 months. A few new lesions were observed after two to six months in four patients, but the lesions were not severe enough to justify reinstitution of dialysis. Two patients developed relapse within two months after cessation of dialytic therapy. One of them was started on dialysis a second time and this was followed by remission of lesions. Five patients were taken as controls and were treated with other modes of therapy including sham dialysis, ultrafiltration without dialysis, or systemic heparinization before they were taken on the dialysis program. Whereas sham dialysis and systemic heparinization had no effect on the skin lesions which responded later to dialytic therapy, the ultrafiltration procedure was followed by partial regression of psoriasis. Dialysis appears to have a definite role in the treatment of psoriasis.

Adolescent↗
PubMed1982

Viability of M. leprae under normal and adverse atmospheric conditions.

Harvested bacilli from fresh lepromas were subjected to drying at room temperature for varying periods, were exposed to direct sun-rays, UVR, and were then injected into the foot pads of thymectomised irradiated mice for checking the viability. The organisms could survive UVR for 30 minutes, direct sunlight for 2 hours and room temperature for 7 days. Details are presented.

Animals↗
PubMed1982

In vivo and in vitro drug metabolism in patients with leprosy.

Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed. However, no significant correlation could be obtained between drug half lives and drug metabolising enzymes or with any of the liver function tests in these patients. The findings indicate that drug metabolism is impaired in leprosy patients.

Adolescent↗
PubMed1982

Clinico-pathological study of testicular involvement in leprosy.

Twenty five patients of lepromatous leprosy were studied clinically and histopathologically for testicular involvement. Testicular pain or swelling was the commonest complaint (68%) followed by sterility (28%) and impotence (4%). Reduced testicular size associated with soft feel was observed in 76% patients. Gynaecomastia was present in 36% and altered sexual hair pattern in 24%. Eleven out of sixteen (69%) patients had oligo/azoospermia. Out of the twenty testicular biopsies 15 (75%) had definite histological evidence of leprous pathology, irrespective of testicular size, semen picture and clinical signs and symptoms. One out of three epididymal biopsies showed minimal changes. Histopathological changes varied markedly, it was not possible to categorize these into vascular, interstitial and obliterative phases.

Adolescent↗
PubMed1982

Total and differential serum proteins and globulins in leprosy.

Total and differential serum proteins were estimated in 177 adult male patients and globulins in 135 patients. Total serum proteins were slightly lowered in BB, BL and LL patients. Total albumin was low in all types of leprosy, especially in the BL group. Alpha-1 and alpha-2 fractions were unchanged all through the leprosy spectrum. Beta globulins were significantly lowered in LL patients as compared to the controls. Gamma globulins were elevated in all types of leprosy more so in BB, BL and LL patients. Details are presented.

Adolescent↗
PubMed1982

Endemicity of leprosy in the Union Territory of Chandigarh and surrounding states.

Data on 603 leprosy patients registered with the Leprosy clinic at the Nehru Hospital attached to Postgraduate Institute of Medical Education and Research, Chandigarh was analysed. The sample was collected over a period of 6 years in this area of very low endemicity. The overall average age at onset of the disease was 35.07 years. Majority of the patients had contacted the disease by the age of 39 years. Only 2% patients presented with the disease in the first decade. Males were more often seen with the disease than the females (M:F, 3:6:1). The highest represented type of leprosy was borderline (47.7%) and least represented was lepromatous (24.4%) with tuberculoid group inbetween (27.9%). The most common sites of first lesion were the exposed areas i.e. hand, trunk, feet and forearm. Most of the patients came from high prevalence states of the country. There were, however, 118 Punjabis and 41 Haryanvis who had never been outside their home states to any endemic area. The findings are presented.

Adolescent↗
PubMed1982

Concomitant occurrence of leprosy and tuberculosis--a clinical, bacteriological and radiological evaluation.

One hundred and seventeen consecutive patients of leprosy were bacteriologically and radiologically investigated for evidence of concomitant tuberculosis anywhere in the body. Out of the total, only 9 patients (7.7%) showed evidence of active tuberculosis bacteriologically and/or radiologically. Three patients had sputum positive for AFB, 2 out of these were radiologically negative while one had evidence of pulmonary tuberculosis. From 7 patients with radiological evidence of tuberculosis, tubercle bacilli could be grown in only one. Tuberculosis was found to occur throughout leprosy spectrum. It is important to recognise the presence of tuberculosis in leprosy patients so that proper therapeutic measures may be taken to avoid monotherapy of tuberculosis.

Adolescent↗
PubMed1981

Penile tinea.

Explore the source record for details and available documents.

Adolescent↗
PubMed1981

Progressive diaphyseal dysplasia (Engelmann disease(: scintigraphic-radiographic-clinical correlations.

Four patients (2 males, 2 females; ages 15-47 yrs.) with variable clinical, radiographic, and scintigraphic manifestations of progressive diaphyseal dysplasia (PDD) or Engelmann disease were studied with 99mTc methylene diphosphonate bone imaging and radiographic skeletal surveys. Comparison of the results of the two imaging procedures showed that some affected bones were scintigraphically normal but radiographically abnormal and vice versa. These findings suggest that the lesions of PDD may mature, causing a significant decrease in disease activity, and that abnormally increased radiopharmaceutical accumulation during bone scintigraphy appears to be a sensitive indicator of disease activity.

Adolescent↗
PubMed1981

Positron tomographic imaging of the liver: 68 Ga iron hydroxide colloid.

A new radiopharmaceutical, 68Ga ion hydroxide colloid, for hepatic imaging by positron emission tomography was prepared from the eluate of a 68Ge-68Ga solvent extraction generator. In rats, 84% of the administered dose of colloid localized in the liver and 4.6% accumulated in the spleen. Initial imaging studies in normal dogs showed close correspondence of the findings by positron tomography and transmission computed tomography. Emission tomography with 68Ga-colloid was performed in 10 patients with hepatic metastases demonstrated by conventional 99mTc sulfur colloid scintigraphy. All focal defects noted on the conventional scintigrams were easily identified and generally were seen more clearly by positron tomography. In one patient, additional lesions not identified on the initial 99mTc sulfur colloid images were demonstrated. The positron tomographic images were compared with those obtained by transmission computed tomography in seven patients; the two studies showed comparable findings in five patients, whereas positron tomography more clearly showed multiple lesions in two. Our results suggest that positron emission tomography is a suitable technique for obtaining high contrast, cross-sectional images of large abdominal organs.

Animals↗