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B L Anderson

Publications and source records attributed to B L Anderson.

At least 19 recordsLinked to original sources
PubMed2003

Design of delay elements in a binary optical true-time-delay device that uses a White cell.

A White-cell-based binary optical true-time-delay device has two parts: the controller, or switching engine, and the delay elements. Here we discuss in detail the design of both glass blocks and lens trains as delay elements. Glass blocks can be used in our design for delays ranging from one to a few hundred picoseconds. Lens trains are suitable for longer delays. We also analyze the loss associated with each design and give design limits.

Journal Article↗
PubMed2001

Motion direction, speed and orientation in binocular matching.

The spatial differences between the images seen by the two eyes, called binocular disparities, can be used to recover the volumetric (three-dimensional) aspects of a scene. The computation of disparity depends upon the correct identification of corresponding features in the two images. Understanding what image features are used by the brain to solve this matching problem is one of the main issues in stereoscopic vision. Many cortical neurons in visual areas V1 (ref. 2), MT (refs 3, 4) and MST (refs 5, 6) that are tuned to binocular disparity are also tuned to orientation, motion direction and speed. Although psychophysical work has shown that motion direction can facilitate binocular matching, the psychophysical literature on the role of orientation is mixed, and it has been argued that speed differences are ineffective in aiding correspondence. Here we use a different psychophysical paradigm to show that the visual system uses similarities in orientation, motion direction and speed to achieve binocular correspondence. These results indicate that cells that multiplex orientation, motion direction, speed and binocular disparity may help to solve the binocular matching problem.

Depth Perception↗
PubMed2001

Occlusion junctions do not improve stereoacuity.

Occlusion geometry gives rise to interocular shifts in the positions of binocularly viewed contour junctions. Since these shifts do not give rise to normal binocular disparities, they have been called 'pseudodisparities'. Previous work has shown that the unmatched contour segments of a partially occluded contour at occlusion junctions can be used to recover the geometry of the occluding surface through the construction of 'illusory' contours. Here, experiments were performed to determine whether such junction shifts could enhance stereoscopic depth detection when the relative disparity between the contours was below threshold. Our results showed that stereoscopic depth detection does not improve when pseudodisparity is present. We conclude that the visual system is less sensitive to pseudodisparity than to conventional disparity information. We suggest that the primary role of pseudodisparity is to overcome conditions of camouflage.

Cues↗
PubMed1999

Stereoscopic occlusion and the aperture problem for motion: a new solution.

Recent work has shown that the ability of moving contour terminators to determine the perceived motion of untextured contours is strongly constrained by whether contour terminators are classified as intrinsic (belonging to a moving contour) or extrinsic (belonging to a surface occluding a moving contour). It has also been demonstrated that stereopsis can play a decisive role in this classification. Specifically, Shimojo, Silverman and Nakayama (1989, Vision Research 29, 619-626) argued that the efficacy of stereopsis in classifying moving contour terminators as intrinsic or extrinsic stemmed from the relative depth relationships specified by binocular disparity. Here, evidence is presented which demonstrates that the visual system relies on the presence of unpaired contour terminators to classify stereoscopic contour terminators as extrinsic. The author shows that the tendency to perceive untextured contours translating in a single rectangular aperture in a direction parallel to the longer axis of the aperture (the barberpole illusion) was not abolished by stereoscopic depth differences when the contour terminators were interocularly paired. However, the illusion was abolished when the contours terminators along the longer axis of the aperture were interocularly unpaired. Moreover, contours translated within a square aperture revealed a systematic shift towards the direction of motion signaled by the binocularly paired contour terminators along the horizontal edges of the aperture. These results demonstrate that the classification of stereoscopic contour terminators along an extrinsic-intrinsic dimension results from the presence of local, unpaired contour terminators rather than the relative depth or disparity differences per se, or via the global integration of contour terminators across multiple apertures when multiple apertures are present.

Depth Perception↗
PubMed1999

Motion-based mechanisms of illusory contour synthesis.

Neurophysiological studies and computational models of illusory contour formation have focused on contour orientation as the underlying determinant of illusory contour shape in both static and moving displays. Here, we report a class of motion-induced illusory contours that demonstrate the existence of novel mechanisms of illusory contour synthesis. In a series of experiments, we show that the velocity of contour terminations and the direction of motion of a partially occluded figure regulate the perceived shape and apparent movement of illusory contours formed from moving image sequences. These results demonstrate the existence of neural mechanisms that reconstruct occlusion relationships from both real and inferred image velocities, in contrast to the static geometric mechanisms that have been the focus of studies to date.

Brain↗
PubMed1999

Stereoscopic surface perception.

Physiological, computational, and psychophysical studies of stereopsis have assumed that the perceived surface structure of binocularly viewed images is primarily specified by the pattern of binocular disparities in the two eyes' views. A novel set of stereoscopic phenomena are reported that demonstrate the insufficiency of this view. It is shown that the visual system computes the contrast relationships along depth discontinuities to infer the depth, lightness, and opacity of stereoscopically viewed surfaces. A novel theoretical framework is introduced to explain these results. It is argued that the visual system contains mechanisms that enforce two principles of scene interpretation: a generic view principle that determines qualitative scene geometry, and anchoring principles that determine how image data are quantitatively partitioned between different surface attributes.

Algorithms↗
PubMed1999

Stereoscopic occlusion junctions.

Portions of surfaces in a binocularly viewed scene may be 'half occluded', that is, visible in only one eye. The human visual system uses zones of half occlusion to help segment the visual scene and infer figure-ground relationships at object boundaries. We developed a quantitative model of the depth-discontinuity cue provided by half occlusion. Half occlusions are revealed by two-dimensional interocular displacements of binocularly viewed occlusion junctions, such as T junctions. We derived a formula relating this two-dimensional displacement, or 'pseudodisparity', to binocular disparities and orientations of occluding and occluded contours. In human psychophysical experiments, perceived depth and contour orientation quantitatively depended on pseudodisparity, as predicted by our model, implying that the visual system senses quantitative variations in interocular junction position to reconstruct occlusion geometry.

Depth Perception↗
PubMed1998

The Src homology domain 3 (SH3) of a yeast type I myosin, Myo5p, binds to verprolin and is required for targeting to sites of actin polarization.

The budding yeast contains two type I myosins, Myo3p and Myo5p, with redundant functions. Deletion of both myosins results in growth defects, loss of actin polarity and polarized cell surface growth, and accumulation of intracellular membranes. Expression of myc-tagged Myo5p in myo3Delta myo5Delta cells fully restores wild-type characteristics. Myo5p is localized as punctate, cortical structures enriched at sites of polarized cell growth. We find that latrunculin-A-induced depolymerization of F-actin results in loss of Myo5p patches. Moreover, incubation of yeast cells at 37 degrees C results in transient depolarization of both Myo5p patches and the actin cytoskeleton. Mutant Myo5 proteins with deletions in nonmotor domains were expressed in myo3Delta myo5Delta cells and the resulting strains were analyzed for Myo5p function. Deletion of the tail homology 2 (TH2) domain, previously implicated in ATP-insensitive actin binding, has no detectable effect on Myo5p function. In contrast, myo3Delta myo5Delta cells expressing mutant Myo5 proteins with deletions of the src homology domain 3 (SH3) or both TH2 and SH3 domains display defects including Myo5p patch depolarization, actin disorganization, and phenotypes associated with actin dysfunction. These findings support a role for the SH3 domain in Myo5p localization and function in budding yeast. The proline-rich protein verprolin (Vrp1p) binds to the SH3 domain of Myo3p or Myo5p in two-hybrid tests, coimmunoprecipitates with Myo5p, and colocalizes with Myo5p. Immunolocalization of the myc-tagged SH3 domain of Myo5p reveals diffuse cytoplasmic staining. Thus, the SH3 domain of Myo5p contributes to but is not sufficient for localization of Myo5p either to patches or to sites of polarized cell growth. Consistent with this, Myo5p patches assemble but do not localize to sites of polarized cell surface growth in a VRP1 deletion mutant. Our studies support a multistep model for Myo5p targeting in yeast. The first step, assembly of Myo5p patches, is dependent upon F-actin, and the second step, polarization of actin patches, requiresVrp1p and the SH3 domain of Myo5p.

Actins↗
PubMed1997

Reciprocal interactions between occlusion and motion computations.

The "aperture problem" refers to the inherent ambiguity of the motion generated by an untextured contour moving within an aperture. The limited spatial extent of the receptive fields of neurons in cortical areas like V1 and MT render them susceptible to this problem. Most psychophysical experiments have probed how the visual system overcomes the aperture problem by presenting moving contours behind one or more simulated apertures. The assumption has been that the computational ambiguities that arise in resolving these displays are equivalent to the computational problems created by receptive fields that sample a small region of visual space. Evidence is presented here that challenges this view. We demonstrate that a fundamental computational difference in the interpretation of contour terminators arises in these two variants of the aperture problem. When the aperture is a receptive field, and a moving contour extends beyond its boundaries, the contour "terminators" delimit the boundaries of the receptive field, not the ends of the contour. In contrast, when a moving contour is viewed through a simulated aperture, the contour terminators are generated by the occluding edges of the aperture. In a series of experiments, we show that reciprocal interactions arise between computations of occlusion and those of motion direction and integration. Our results demonstrate that the visual system solves the aperture problem by decomposing moving contours into moving segments, and unpaired terminators that arise from the accretion and deletion of contours behind occluding edges, generating both coherent motion and illusory occluding surfaces.

Motion Perception↗
PubMed1997

A theory of illusory lightness and transparency in monocular and binocular images: the role of contour junctions.

A theory of illusory transparency and lightness is described for monocular and binocular images containing X-, T- and I-contour junctions. This theory asserts that the geometric and luminance relationships of contour junctions induce illusory transparency and lightness percepts by causing a phenomenal scission of a homogenous luminance into multiple contributions. Specifically, it is argued that a discontinuous change in contrast along aligned contours that preserve contrast polarity induces a scission of the lower contrast region into a near-transparent surface or an illumination change, and a more distant surface that continues behind behind this near layer. This scission is assumed to cause changes in perceived lightness and/or surface opacity. Discontinuous changes in contrast along contours also are assumed to induce end-cut illusory contours that run roughly perpendicular to the inducing orientation of the contour, both monocularly and binocularly. Binocular illusory contours are shown to be caused by the presence of unmatchable contour terminators. It is argued that the presented theory can provide a unified account of a variety of monocular and binocular illusions that induce uniform transformations in perceived lightness, including neon-color spreading, the Munker-White illusion, Benary's illusion, and illusory monocular and binocular transparency.

Contrast Sensitivity↗
PubMed1996

Mapping of unconventional myosins in mouse and human.

Myosins are molecular motors that move along filamentous actin. Seven classes of myosin are expressed in vertebrates: conventional myosin, or myosin-II, as well as the 6 unconventional myosin classes-I, -V, -VI, -VII, -IX, and -X. We have mapped in mouse 22 probes encompassing all known unconventional myosins and, as a result, have identified 16 potential unconventional myosin genes. These genes include 7 myosins-I, 2 myosins-V, 1 myosin-VI, 3 myosins-VII, 2 myosins-IX, and 1 myosin-X. The map location of 5 of these genes was identified in human chromosomes by fluorescence in situ hybridization.

Animals↗
PubMed1996

Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.

The organization of the actin cytoskeleton plays a critical role in cell physiology in motile and nonmotile organisms. Nonetheless, the function of the actin based motor molecules, members of the myosin superfamily, is not well understood. Deletion of MYO3, a yeast gene encoding a "classic" myosin I, has no detectable phenotype. We used a synthetic lethality screen to uncover genes whose functions might overlap with those of MYO3 and identified a second yeast myosin 1 gene, MYO5. MYO5 shows 86 and 62% identity to MYO3 across the motor and non-motor regions. Both genes contain an amino terminal motor domain, a neck region containing two IQ motifs, and a tail domain consisting of a positively charged region, a proline-rich region containing sequences implicated in ATP-insensitive actin binding, and an SH3 domain. Although myo5 deletion mutants have no detectable phenotype, yeast strains deleted for both MYO3 and MYO5 have severe defects in growth and actin cytoskeletal organization. Double deletion mutants also display phenotypes associated with actin disorganization including accumulation of intracellular membranes and vesicles, cell rounding, random bud site selection, sensitivity to high osmotic strength, and low pH as well as defects in chitin and cell wall deposition, invertase secretion, and fluid phase endocytosis. Indirect immunofluorescence studies using epitope-tagged Myo5p indicate that Myo5p is localized at actin patches. These results indicate that MYO3 and MYO5 encode classical myosin I proteins with overlapping functions and suggest a role for Myo3p and Myo5p in organization of the actin cytoskeleton of Saccharomyces cerevisiae.

Actins↗
PubMed1995

Prevention of apoptotic neuronal death by GM1 ganglioside. Involvement of Trk neurotrophin receptors.

We have used serum-deprived cultures of wild type and genetically modified PC12 cells to investigate the molecular mechanisms by which monosialoganglioside (GM1) rescues neuronal cells from apoptotic death elicited by withdrawal of trophic support. Our findings indicate that GM1-promoted survival can be mediated in part by the Trk NGF receptor as well as by TrkB, and potentially by tyrosine kinase receptors for additional neurotrophic growth factors. Experiments employing K-252a, an inhibitor of Trk kinases, and PC12 cells overexpressing a dominant inhibitory form of Trk both indicate that a portion of the survival-promoting activity of GM1 is evoked by receptor dimerization and autophosphorylation. In consonance with this we find that GM1 stimulates Trk tyrosine autophosphorylation and Trk-associated protein kinase activity. These observations may provide a mechanism to account for the reported in vitro and in vivo trophic actions of GM1.

Animals↗
PubMed1994

The role of partial occlusion in stereopsis.

Models of stereopsis typically assume that all the information about stereoscopic depth is contained in the disparity field, that is, the positional differences of image features that arise from surfaces visible to both eyes. But such models have difficulty in resolving image regions containing occlusions, because a portion of the occluded surface is visible to only one of the two eyes ('half-occlusions'). Here I present displays revealing an unexpected relationship between interocular differences in image position and occluding contours. The partial occlusion of contours can give rise to both horizontal and vertical image differences that are not disparities. The results show that the visual system interprets these image differences as signalling the presence of occluding contours. Even when a single line segment serves as a binocular target, subjective contours form that can appear both oriented and in depth. These local subjective contours have a strong tendency to interact cooperatively and form global contours not present in the monocular images. These and other findings show that stereoscopic processing actively decomposes vertical and horizontal image differences into disparities and half-occlusions. The two sources of information are complementary: while disparity provides relative depth information about surface features visible to both eyes, half-occlusions provide information to segment the visual world into coherent objects at object boundaries.

Depth Perception↗
PubMed1994

Toward a general theory of stereopsis: binocular matching, occluding contours, and fusion.

Models of stereopsis have focused on developing strategies for identifying common features in the 2 half-images so that disparity may be computed. This emphasis ignores the unpairable features that arise at occluding contours (half-occlusions). Most models treat half-occlusions as noise or outliers that are interpreted after disparity processing is completed. A series of experiments reveal that occlusion relationships are sensed during the earliest stages of binocular processing. The authors hypothesize the existence of receptive field structures that sense the local structure of stereoscopic occlusion relationships to account for these findings. Finally, a simple theoretical framework is presented in which fusion, stereopsis, and occlusion are unified. This theory explains the co-occurrence of stereopsis and diplopia and how half-occlusions escape the suppression characteristic of binocular rivalry.

Contrast Sensitivity↗