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Biomedical subjects

B L Chia

Publications and source records attributed to B L Chia.

At least 109 records · Page 6Linked to original sources
PubMed1980

Disopyramide induced atypical ventricular tachycardia.

A patient presenting with atypical ventricular tachycardia due to oral disopyramide given in normal doses over a period of four months is described. This arrhythmia was preceded by marked prolongation of the QTc. It is suggested that patients receiving treatment with oral disopyramide should be closely monitored for symptoms of ventricular tachyarrhythmias, particularly in the face of a prolonged QTc.

Administration, Oral↗
PubMed1980

Echocardiographic abnormalities in acute rupture of the aortic valve due to infective endocarditis.

The M-mode echocardiographic findings seen in 5 patients with acute rupture of the aortic valve leaflets due to infective endocarditis are described. These findings embrace a wide spectrum of abnormalities seen in the aortic root in diastole and they are (1) fine, high frequency oscillating echoes, (2) thick oscillating bands of echoes, and (3) dense shaggy echoes loosely attached to the aortic valve leaflets. Three patients showed persistence of these aortic root echoes right up to the level of the left ventricular outflow tract. All 5 patients demonstrated early closure of the mitral valve and exaggerated motion of the interventricular septum and the posterior wall of the left ventricle. Two patients died from the illness and the remaining 3 had successful aortic valve replacement after appropriate antibiotic therapy. The aortic valve and the aortic root were carefully examined in all 5 patients either at necropsy or at operation. Two patients had leaflet perforation alone, whereas the remaining 3 had both leaflet perforations as well as vegetations. An attempt was made to correlate morphologic findings with the echocardiographic abnormalities. It is concluded that it is frequently difficult from abnormal echoes in the aortic root alone to differentiate between ruptured leaflets and vegetations. However, the presence of the combination of early closure of the mitral valve, exaggerated motion of the interventricular septum and the posterior wall of the left ventricle, together with abnormal aortic root echoes as described above should strongly suggest acute rupture of the aortic valve leaflets due to infective endocarditis, or in rare cases myxomatous degeneration of the aortic valve.

Acute Disease↗
PubMed1980

A comparison between once-daily and twice-daily administration of metoprolol in the management of hypertension.

The efficacy of metoprolol as an antihypertensive agent was assessed in 20 previously untreated Asian patients with mild to moderate hypertension. After a 4-week run-in period when placebo therapy was given, the patients were given oral metoprolol at a starting dosage of 100 mg twice daily. The dosage of metoprolol was increased at fortnightly intervals until either satisfactory blood pressure control, defined as a diastolic blood pressure of less than 90 mmHg or a greater than 10% fall in pre-treatment diastolic blood pressure, was achieved or a total of 400 mg metoprolol was reached. All 20 patients had satisfactory control of their blood pressures on a twice-daily regimen and the average dosage of metoprolol required was 200 mg daily. For the second part of the study, the medication was changed to a once-daily regimen at the same total dosage of metoprolol. Final efficacy of once-daily therapy was assessed after 8 weeks of treatment. All blood pressure and pulse rate reductions were significant (P < 0.001) from the placebo phase. However, twice-daily and once-daily readings were not significantly different from each other. No side-effects were reported during the study.

Adult↗
PubMed1980

The current status of echocardiography.

M mode echocardiography first started in the University Department of Medicine in early 1976. There has been a steady increase in the total number of procedures done yearly. The value of M mode echocardiography in the various cardiovascular disorders is discussed and the current status and future prospects of this procedure is reviewed.

Aortic Valve Insufficiency↗