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Biomedical subjects

B Larsen

Publications and source records attributed to B Larsen.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Food composition and serum lipids in children].

The composition of the diet is considered to be one of the factors which may be of significance in development of ischaemic heart disease. In order to investigate whether the composition of the diet has a greater influence on the cholesterol levels in children than in adults, af 24-hour dietary interview was carried out on 42 children aged 7-11 years who had previously been examined in the childrens' section of the Osterbro investigation. The children were selected in three groups with low, average and high serum cholesterol levels, respectively. The dietary content of energy-providing substances was compared with the cholesterol values measured. In addition, the composition of the diet in other respects was described and was found to contain, on an average, 40% fat, 14% protein and 42% carbohydrate (of which 14% was sugar). The cholesterol intake was 146 mg/1,000 Kcal. The sugar consumption was low as compared with the national average, approximately 62 g/day. The protein consumption was approximately 2 g per kg body-weight per day. The median total energy intake was 8,024 KJ for girls and 8,569 KJ for boys lower than the recommended daily values and corresponded to a low levels of physical activity. This investigation showed a definite linear connection between the fat energy percentage and the serum cholesterol (alpha = 5.26 p less than 0.005) and that intake of saturated fatty acids, in particular can be related to the cholesterol level (alpha = 2.88 and p less than 0.005). A significantly greater fat energy intake was demonstrated in girls (p less than 0.05) in the group with high serum cholesterol levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Child↗
PubMed1989

A new polymorphic variant of human complement factor I.

Sera from 305 individuals were typed for factor I, and a new variant, tentatively designated FI C, was found. All other samples were FI B except for seven samples from Chinese that were of the FI AB phenotype. This suggests that polymorphism of factor I may be rare in Caucasians.

Complement C3b Inactivator Proteins↗
PubMed1989

A 15-kD interferon-induced protein and its 17-kD precursor: expression in Escherichia coli, purification, and characterization.

Using recombinant DNA technology, a 15-kD interferon (IFN)-induced protein and its 17-kD precursor have been expressed in Escherichia coli to obtain sufficient quantities of each protein for the investigation of their biological roles. Both the 15-kD and 17-kD proteins have been purified to homogeneity and crystallized. The recombinant 15-kD protein has an identical reversed-phase HPLC elution profile to that of the native 15-kD protein purified from human cells. Furthermore, the recombinant 15-kD and 17-kD proteins have identical amino- and carboxy-terminal amino acid sequences to those predicted from the DNA sequence. The native and recombinant 15-kD proteins give identical tryptic peptide maps, and the recombinant 17-kD protein gives only one additional tryptic peptide. We conclude that the recombinant 17-kD and 15-kD proteins are identical to the 17-kD precursor and the 15-kD stable product synthesized in human cells in response to IFN stimulation. In addition, we have demonstrated that the recombinant 17-kD precursor protein can be converted to the 15-kD protein by cytoplasmic extracts of human cells.

Amino Acid Sequence↗
PubMed1989

[Is there an essence of caring? A core of Nursing? Criticism of Katie Erikssons' "Vårdandets ide"].

In her book "Vårdandets Ide" the Finnish nurse, Katie Eriksson puts forward the thesis, that all kind af caring activities do have a common core. To establish this thesis professor Eriksson introduces the Aristotelian notion of an essence: Different kinds of caring activities do have a common set of essential properties constituting the act of caring. In this article we submit a thesis to the contrary: There may exist no set of essential properties common to all kind of caring activities: The belief is induced in us, that there may exist some common core to all caring activities, because the same term, namely "caring", is being used as a general term to cover a wide field of very different kinds of activities. Instead of the traditional Aristotelian craving for generality issuing in the notion of an essence, we suggest the use of the more modern Wittgensteinian concept of a family resemblance: There may be no common core but a set of family resemblances among the different kinds of caring activities. Instead of an abstract philosophical search for the common core of caring activities, we propose nurses to look at the actual use of the term "to care", thereby circumscribing the subject matter of caring. It goes without saying, that this article contains a good deal of philosophical arguments including, of course, an introduction to some basic Aristotelian notions, fundamental distinctions in the theory of definition, and finally the Wittgensteinian concept of family resemblance.

Humans↗
PubMed1989

Uterine rupture after re-implantation of fallopian tubes.

Spontaneous uterine rupture in the second trimester of pregnancy with twins following a previous re-fertilization is very rare. A case of spontaneous cornual uterine rupture following re-implantation of the Fallopian tubes in a 35-year-old multigravid woman is described. The atypical clinical presentation and the findings at the operation are discussed.

Adult↗
PubMed1988

Genetic polymorphism of plasma alpha 1 B-glycoprotein and transferrin in arctic and silver foxes.

Plasma samples of 235 foxes from 38 complete families (14 of arctic foxes, 21 of silver foxes and 3 with arctic x silver fox hybrid offspring) were analysed by one-dimensional horizontal polyacrylamide gel electrophoresis (PAGE) pH 9.0 followed by general-protein staining of gels. A major postalbumin of fox plasma was identified as alpha 1B-glycoprotein (alpha 1B) by using immunoblotting with antiser m specific to human or pig plasma alpha 1B. Four codominant, autosomal alleles of alpha 1B were found in arctic foxes. Two transferrin (TF) alleles (TfF, TfS) were observed in arctic foxes and two (TfD, Tff) in silver foxes; the TF F type of both of the fox species showed identical electrophoretic mobilities. The arctic foxes showed a high degree of polymorphism for both TF and alpha 1B. The silver foxes showed a scarce polymorphism of TF and were monomorphic for alpha 1B. The arctic fox, silver fox and their hybrids could be clearly differentiated from one another by their plasma protein patterns obtained by the PAGE method.

Alleles↗
PubMed1988

Intrarenal blood flow distribution in dog kidney determined by 99mTc microaggregates and 201Tl.

Intrarenal distribution of blood flow was assessed with radioactive albumin microaggregates (MA) in three cortical zones of the dog kidney. The experimentally obtained zonal fractions of total renal blood flow were compared with predicted zonal blood flow fractions obtained in a mathematical model. The maximal degree of skimming that could possibly occur in a single experiment was estimated. The analysis showed that local blood flow in the inner cortical zone was maximally underestimated by 17% because of skimming of MA, and in the outer cortical zone the blood flow was maximally overestimated by 13% with the method of radioactive MA uptake. Renal uptake of 201Tl was measured simultaneously in exactly the same locations. Paired measurements of intrarenal blood flow distribution by MA and Tl uptake methodologies showed that local blood flow assessed with MA in the inner cortical zone was significantly lower than that obtained with 201Tl and that a higher blood flow rate was obtained in the outer cortical zone with MA compared with 201Tl. This disparity could be accounted for by the effect of skimming of MA as predicted by the model.

Animals↗
PubMed1987

Evaluation of vaginal malodor and efficacy of treatment by high performance ion exchange chromatography.

High performance ion exchange chromatography was employed to evaluate the presence of short chain organic acids in the vaginal fluid of a woman troubled by persistent foul vaginal odor, but who did not have typical bacterial vaginosis. The vaginal secretions from this patient were collected on a weighed cotton swab and eluted into water and extracted by acidified ether. Salts of the acids were back-extracted into aqueous solution and chromatographed on an H-form resin column and compared to commercially available standards. A strikingly large amount of caproic acid was found. The caproic acid disappeared after metronidazole therapy, and a subsequent follow-up chromatogram showed a predominance of lactic acid. The success of this technique in evaluating the present case suggests that such a method may prove useful in other types of vaginal infection.

Adult↗
PubMed1987

Phosphate content of human amniotic fluid and its relationship to bacterial growth inhibition.

A sensitive method for assay of phosphate has been adapted for use with human amniotic fluid. The presence of an antibacterial factor in amniotic fluid inactivated by phosphate suggested that measurement of free phosphate may predict antibacterial activity and hence susceptibility to intrapartum infection. The intrinsic antibacterial activity of amniotic fluid was altered by addition of large amounts of phosphate, but the intrinsic concentration of free phosphate correlated poorly with antibacterial activity and organically combined phosphates did not appear to be related to the antibacterial property.

Amniotic Fluid↗
PubMed1987

Familial giant hypertrophic gastritis (Ménétrier's disease).

Familial giant hypertrophic gastritis involving three generations is reported. A review of the literature, where approximately 200 cases are described, showed only few cases of familial occurrence of this disease, and only in siblings. Our findings suggest dominant heredity, but considering the sparsity of familial occurrence reported earlier, heredity seems to be of only minor pathogenetic significance.

Adolescent↗
PubMed1987

Mucoid strains of Pseudomonas aeruginosa are devoid of mannuronan C-5 epimerase.

Mucoid strains of Azotobacter vinelandii, Pseudomonas aeruginosa and Pseudomonas syringae var glycinia synthesize alginate, an extracellular copolymer comprising D-mannuronosyl and L-guluronosyl moieties. Extracellular mannuronan C-5 epimerase, which converts polymannuronate to alginate, was demonstrated in supernatant fluid from cultures of A. vinelandii. However, the enzyme could not be demonstrated, using the same assay, in supernatant fluids of cultures of mucoid strains of P. aeruginosa or of P. syringae var glycinia, or in cell-free sonic extracts of P. aeruginosa. The results suggest that the pathways of alginate biosynthesis in A. vinelandii and Pseudomonas species may differ.

Alginates↗