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Biomedical subjects

B Leroy

Publications and source records attributed to B Leroy.

88 records · Page 5Linked to original sources
PubMed1978

[The value of echography in cases of threatened abortion in the first trimester of pregnancy (author's transl)].

Echographic examination brings to the screening and determination of the seriousness of a threatened abortion features of prime importance. These are such as to change greatly the management. They are concerned with: --on the one hand the morphology of the oocyte, --and on the other hand the recognition and evaluation objectively of the criteria of the viability of the embryo and the activity of its heart and its motility.

Abortion, Threatened↗
PubMedDate not supplied

Oral telithromycin 800 mg once daily for 5 days versus cefuroxime axetil 500 mg twice daily for 10 days in adults with acute exacerbations of chronic bronchitis.

The efficacy and safety of a 5-day regimen of 800 mg telithromycin once daily was compared with a standard 10-day regimen of 500 mg cefuroxime axetil twice daily in a multicentre, randomized, double-blind, parallel-group trial involving 376 patients with acute exacerbations of chronic bronchitis (AECB). In clinically evaluable patients (n = 282), post-therapy clinical cure rates were 86.4% with telithromycin and 83.1% with cefuroxime axetil. In bacteriologically evaluable patients (n = 53), eradication or presumed eradication of the pathogen was achieved in 76.0% and 78.6% of telithromycin and cefuroxime axetil patients, respectively. Adverse events were mostly mild; the most common were diarrhoea (12.8% versus 11.8%) and nausea (8.9% versus 3.2%) in telithromycin and cefuroxime axetil patients, respectively. The 5-day regimen of 800 mg telithromycin once daily was similar in efficacy and equally well tolerated as a 10-day regimen of 500 mg cefuroxime axetil twice daily in adults with AECB.

Administration, Oral↗
PubMedDate not supplied

[Personality changes in opioid-dependent subjects in a methadone maintenance treatment program].

Personality disorders and particularly antisocial personality disorders (APD) are quite frequent in opioid-dependent subjects. They show various personality traits: high neuroticism, high impulsivity, higher extraversion than the general population. Previous studies have reported that some but not all personality traits improved with treatment. In a previous study, we found a low rate of APD in a French population of opioid-dependent subjects. For this reason, we evaluated personality traits at intake and during maintenance treatment with methadone. Methods - The form A of the Eysenck Personality Inventory (EPI) was given to opioid addicts at intake and after 6 and 12 months of methadone treatment. Results - 134 subjects (96 males and 38 females) took the test at intake, 60 completed 12 months of treatment. After 12 months, the EPI Neuroticism (N) and the Extraversion-introversion (E) scale scores decreased significantly. The N score improved in the first 6 months, while the E score improved only during the second 6 months of treatment. Compared to a reference group of French normal controls, male and female opioid addicts showed high N and E scores. Demographic data and EPI scores of patients who stayed in treatment for 12 months did not differ significantly from those of dropouts (n=23). Patients with a history of suicide attempts (SA) started to use heroin at an earlier age and they showed a higher E score and a tendency for a higher N score at intake. Discussion - The two personality dimensions of the EPI changed during MMT, and the N score converged towards the score of normal controls. Opioid addicts differ from normal controls mostly in their N score. The EPI did not help to differentiate 12-month completers from dropouts. Higher E scores in patients with an SA history might reflect a higher impulsivity, which has been linked to suicidality in other patient groups.

Adult↗
PubMedDate not supplied

[Cardiomyopathy due to 5-fluorouracil].

We report a new case of myocardiotoxicity due to 5 fluorouracil. A patient shows immediately after the first cure of chemotherapy where 5 fluorouracil was associated with cisplatinum, a circulatory failure which will need a controlled ventilation and a catecholamine treatment. Right catheterization and two-D echocardiography will confirm the alteration of myocardial contractility. The patient condition will favorably and quickly evolve towards normalisation of the cardiac examination at the third week.

Cardiomyopathies↗
PubMedDate not supplied

[Growth retardation and amino acids. Analysis of maternal plasma and amniotic fluid].

We have carried out an analysis of the amino acids in the mother's plasma and in the liquor amnii of 26 pregnant women who delivered either normal premature babies or those with intra-uterine growth failure. The levels found at delivery showed no difference in cases of prematurity in the composition of the substances in the plasma, but the liquor is poor in glycocol (GLY), Tyrosine (TYR), Phenylalanine (PHE). In the case of growth failure a significant drop in the concentration of Threonine (THR), Alanine (ALA), Valine (VAL), Methionine (MET) and Arginine (ARG) was found in the plasma. The liquor amnii however had shown no change in composition.

Alanine↗
PubMedDate not supplied

[Antiprothrombinase anticoagulant and acquired prothrombin deficiency in childhood viral pathology. Spontaneous recovery].

A 2 year-old female developed an acute bleeding diathesis related to a profound, isolated and acquired prothrombin deficiency; evidence for a "lupus anticoagulant" was also demonstrated. This association of hypoprothrombinemia and "lupus anticoagulant", rarely reported, was previously considered to be rather specific for SLE. This case report demonstrates that these coagulation disorders may present as an acute form, in viral diseases of the child, with spontaneous and quick recovery. Specific characteristics of the biological coagulation defects, namely those related to the low factor II, are discussed.

Blood Coagulation Factors↗