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Biomedical subjects

B Lindell

Publications and source records attributed to B Lindell.

At least 55 records · Page 3Linked to original sources

Repeated arterial embolization of rat livers by degradable microspheres.

A transient arrest of arterial blood flow can be accomplished by intra-arterial injection of a new type of degradable microsphere. The effects of single and multiple injections of these microspheres into rat hepatic arteries were studied by measurements of fractional cardiac output distribution and 133Xe washout from the liver before and after embolization. Injection of these microspheres into the hepatic artery caused a significant but transient reduction of the arterial blood flow to the liver. Repetition of the injection several times over several days produced identical effects on each embolization. No signs of hepatic cell damage were detected after repeated embolization, as suggested by assay of the serum enzymes or the Bromsulphalein retention test.

Animals↗

Hypophosphataemia in severe burns.

A retrospective study was made of 17 severely burned patients with special reference to serum and urinary phosphate. A lowering of the serum phosphate level was regularly recorded between the 3rd and 9th day. The lowest mean value of serum phosphate of the group was 0.57 +/- 0.2 (S.D.) mmol/l (normal range 0.8-1.5 mmol/l) occurring on the 5th day after the accident. Serum phosphate then returned to normal levels in all the patients except three, who died. These three were among the four patients who showed the lowest serum phosphate values, less than 0.32 mmol/l, and their deaths coincided with the recording of these low values. The phosphate depletion seemed to be of prerenal origin. Hypophosphataemia may be of significance in the fatal outcome in some of the patients with severe burns.

Adult↗

Changes in cardiac output distribution after liver dearterialization in the rat.

The changes in cardiac output distribution in rats have been studied after hepatic artery ligation and additional ligament division. These procedures resulted initially in a marked decrease in the arterial blood supply to the liver and this effect was pronounced still four weeks after the operation. Evidence was found that the decrease in liver blood supply induced by the procedure was in part counterbalanced by arteriovenous shunting in the preportal region. Furthermore, a temporary redistribution of cardiac output with reduced fractions to colon and spleen was found two weeks after these operations.

Animals↗

Urolithiasis. A study of its frequency.

Considering the general impression of an increased number of patients with acute renal colic, the frequencies of roentgenologically verified ureteral and kidney calculi in a Swedish urban district have been studied for the periods 1953-55 and 1968-70. In a material of 986 outpatients (793 men and 193 women) we have proved an increase in incidence for upper urinary tract calculi in men from 2.2 to 3.3 0/00 (p less than 0.001) and in women from 0.5 to 0.8 0/00 (0.01 less than p less than 0.05). For the material as a whole, we have found a 50% increase (from 1.3 to 2.0 0/00; p less than 0.001) of acute urolithiasis between the periods studied. Some implications of the results in connection with primary hyperparathyroidism are discussed.

Adult↗