Thyroid function after subtotal resecti-n for hyper-thyroidism: a prospective study.
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Biomedical subjects
Publications and source records attributed to B Lundström.
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Parathyroid tissue was transplanted from the neck to the muscles of the non-dominant forearm in 18 patients. The difference in concentration of parathormone between the transplant arm and the contralateral arm was used as a test of parathyroid function. All patients showed a difference in concentration between the arms. Three patients needed calcium supplement for 2 months after surgery, and one patient with no parathyroid tissue left in situ also needed vitamin D for 8 months. The results indicate that parathyroid tissue transplanted to the arm continues to function, and is able to keep the patient normocalcaemic even when no parathyroid tissue is left in situ.
The angiographic appearance of 9 cases of genuine giant-cell tumour of bone, 6 cases of aneurysmal bone cyst and one case of non-ossifying fibroma is described. Differential diagnosis would appear to be possible to a certain extent. The non-ossifying fibroma was poorly vascularized. The genuine giant-cell tumours were hypervascularized as well as some of the aneurysmal bone cysts making a differential diagnosis in these cases impossible. On the other hand, a poorly vascularized tumour devoid of soft tissue component and arteriovenous fistulas is probably an aneurysmal bone cyst. A hypervascular soft tissue component is of great prognostic value in cases of geniune giant-cell tumour.
A case of extrahepatic obstruction of the common bile duct and the portal vein by a retroperitoneal neurolemmoma is described. In the initial stages portal hypertension with hepatofugal collaterals and bleeding from oesophageal varices existed. Then gradually, hepatopetal anastomoses developed, partly via veins in the wall of the gallbladder. Such venous collaterals tend to reduce the portal hypertension, but may cause bleeding from the gallbladder.
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The size of the remnant gland after subtotal thyroidectomy varied between 5 and 12 g in 85 hyperthyroid patients. The patients were then examined 6 weeks and 6 months after surgery with estimation of TSH and TRH stimulation test as well as thyroxine and triiodothyronine. A significant correlation between TSH response to TRH and remnant weight was found ( r= 0.94, p less than 0.01). The frequency of raised S-TSH was higher in the group with small remnants compared with those with larger ones. There was only minor correlation between raised S-TSH or high TSH response to TRH and remnant size expressed in per cent of the total thyroid weight (relative remnant size). No significant difference in thyroxine and triiodothyronine was found between the weight groups. Hypothyroidism developed in two patients with small remnants (6 g) and in one patient with a remnant weight of 8 g. Recurrent hyperthyroidism occurred in one patient in the 8-gram weight group. These results indicate that the remnant size may be one factor influencing the outcome of thyroid function after surgery.
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Radiography of 60 normal wrists was performed in 50 adults to determine the inclination of the distal joint surface of the radius. The central ray was directed 10 degrees proximally in postero-anterior projection and 15 degree proximally in lateral projection. The values obtained were compared with those from perpendicular projections. No dfferences were found between the two p.a. projections. In the lateral projection with the central ray directed proximally the measuring points were better defined, resulting in significantly increased exactness of the measurement. The mean value for the volar inclination was 9 degrees in the latter projection.
Model cholangiographic experiments were performed in which the relationship between contrast medium concentration, duct diameter, calculus size and tube potential was analysed. The same degree of diagnostic reliability was obtained by increasing the tube potential as by diluting the contrast medium. A tube potential of 100 to 110 kV and a contrast medium concentration of 45 per cent were found to give the best result if the background density of the film was held constant.
Radiography of 40 wrists with fractures in the distal part of radius was performed. In the lateral view the inclination of the radial joint surface was analysed in different degrees of pronation and supination. The central ray was directed 15 degrees proximally and the results were compared with those obtained with a perpendicular central ray. In the perpendicular projections even moderate differences in pronation or supination between two examinations could seriously alter the measured inclination of the joint surface of the radius. The projection with the central ray directed 15 degrees proximally highly significantly decreased the errors between the measurements when compared to the perpendicular projection. The joint surface was depicted more dorsally inclined than in the perpendicular projection.
A case of bilateral aneurysmatic widening of the Dacron graft after aorto-femoral bypass is described. The probable cause of an aneurysm in Dacron graft without any involvement of the host vessels may be the rupture of the Dacron fibres due to fatigue of the material. Furthermore, a contributory cause of aneurysm in our case may be the fact that both anastomoses were performed at nearly right angles causing turbulence.
193 patients operated on for hyperthyroidism were examined at follow up a mean 4.5 years after operation (range 1-6 years). The patients were examined clinically and biochemically. It was found that 4.6% had a permanent paralysis of the recurrent nerve and 2.6% a permanent hypoparathyroidism. Recurrent hyperthyroidism was found in 2.6%. The patients were grouped according to the results of basal S-TSH and the TRH-stimulation test. Within the groups it was found that all patients with a normal basal TSH were clinically euthyroid. 35 patients had a raised basal TSH or a hypothyroid pattern in the TRH-test, or both. Among these, 14 clinically hypothyroid patients were found. The remaining 21 patients were euthyroid clinically and were classified as subclinically hypothyroid. The levels of basal TSH were significantly higher in subclinically hypothyroid patients than in euthyroid patients and still higher in clinically hypothyroid patients. The response to TRH stimulation was also higher in the hypothyroid patients than in the subclinically hypothyroid patients. It was also found that the proportion of clinically hypothyroid patients was significantly higher, after 5 years than after one year. Since it cannot be decided if the patients with a subclinical hypothyroidism are at risk for manifest disease a close follow up of these patients is recommended.
The action of insulin (0.1 U/ml) on the metabolism of human intestinal smooth muscle was studied in vitro. The experiments were performed on the muscle layer of human jujunum obtained from patients undergoing intestinal shunt operations because of obesity. Insulin significantly increased glucose uptake, glycogen content, the membrane transport of alpha-amino-isobutyric acid (AIB), the incorporation of leucine into protein and tended to increase the membrane transport of the nonutilizable model monosaccharide 3-0-methylglucose. The effects of insulin were moderate and appeared after incubation times of 120 to 180 min.
Nephroangiography has been performed in 35 patients with epidemic nephropathy during the course of the renal lesion phase. In addition to enlarged kidney with thickened cortex, generalized renal vasodilatation was demonstrated in the majority of the cases, frequently combined with rapid circulation. Thus, contrary to previous assumptions, acute oliguric renal insufficiency may also occur in cases with peripheral renal vasodilatation. The angiographic appearance of epidemic nephropathy was characteristic and most evident in the oliguric and anuric phases. Nephroangiography in acute oliguric renal failure may thus be of value for the differential diagnosis and thereby influence the clinical management of the patient.
Three cases of Wegener's granulomatosis with a classical course are described, 2 of which with fatal outcome in spite of immuno-suppressive therapy. Nephroangiography was performed during the oliguric or anuric phase. The appearances were similar to those encountered in glomerulonephritis and were compared with those in three cases of panarteritis nodosa. Two of these represented the classical form with intrarenal arterial aneurysms; the third was a case of the microscopic type presenting blurred intrarenal arteries with lumen variations and occlusions. These observations support the opinion that Wegener's granulomatosis nodosa are different diseases. Nephroangiography seems to be of value in their differentiation.
Different haemodynamic and functional parameters were studied in 5 cases of acute epidemic nephritis with uraemia using nephroangiography and dye-dilution measurements combined with determination of extraction ratio and clearance for 51Cr-EDTA and PAH. In the acute phase, with greatly reduced renal function, increased vascular resistance was noted in spite of the vasodilatation observed in the renal artery out to and including the interlobular arteries. Moreover, angiography revealed enlarged kidneys with an increase in the thickness of the cortex and reduced cortical contrast accumulation. The renal blood flow, which was normal or slightly reduced initially, increased during convalescence, and renal function returned to normal. The investigation indicated that a primary vascular lesion in glomerular to postglomerular capillaries gives rise to pronounced interstitial oedema, which, probably as a result of secondary tubular compression, may be the cause of the rapidly developing renal failure.
In 13 patients operated on with jejuno-ileal shunting for extreme obesity the serum activity of ornithine-carbamoyl-transferase (S-OCT) was monitored. A rapid rise in the S-COT occurred and was observed at its peak between 2 and 8 hours after the operation. In 4 patients operated on for intestinal diseases much smaller rises in the S-OCT were noted. In a control group of 6 patients operated on for knee injuries, no changes of the S-OCT were noted after operation. The rise in the S-OCT is interpreted as a sign of liver cell damage of unknown cause in the patients with jejuno-ileal shunting.