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Biomedical subjects

B M Aliev

Publications and source records attributed to B M Aliev.

At least 19 recordsLinked to original sources
PubMed2006

[Comparative assessment of the five-year results of surgical, combined, radiation and chemoradiotherapy in laryngeal cancer (T3N0M0)].

Four modalities of specific treatment for laryngeal cancer were compared in 158 patients. Five-year survival after chemoradiotherapy using cisplatin, 5-FU and bleomycin plus irradiation (65-70 Gy) was 87% versus 69.7; 66.2 and 45.9% after surgical, combined and radiotherapy, respectively. Chemoradiotherapy failed in 22.4%, as compared with 28.9; 31.5 and 41.7% after the alternative modalities, respectively. Organ preservation was used in 30.3% of surgical cases and 58%--in combined treatment group.

Adult↗
PubMed2000

[Long-term results of hyperfractionated radiotherapy in patients with stage III-IV oropharyngeal carcinoma].

Radiotherapy was given to 139 patients with oropharyngeal carcinoma (stage III-IV) divided into two groups. Group I included 82 patients who received three daily equal fractions (1 Gy), at 4 hr interval, of a mean total focal dose of 80 Gy. Patients in group II (57) received a mean total dose of 68 Gy in 5 weekly standard fractions. Fractionated treatment was carried out in both groups in three stages at 17-day intervals. Complete remission was achieved in 50 (60.9%) patients in group I and in 31 (54.4%)--group II. Total 5-year and recurrence-free survival was 37.3 +/- 5.4 and 32.4 +/- 5.2% (group I) and 12.5 +/- 4.7 and 10.4 +/- 4.4% in group II, respectively. Radiation injury rates were nearly identical in both groups: 14% for standard radiotherapy and 12% for multiple fractions. The data point to high effectiveness of the latter.

Adult↗
PubMed1991

[Results of the treatment of cancer of the movable part of the tongue with clinically intact regional lymph nodes].

A study was made of the frequency of metastatic spreading to the regional neck lymph nodes and long-term results of therapy of 126 patients with cancer of the movable part of the tongue with clinically intact regional lymph nodes of the neck. With regard to an employed modality (irradiation, alone and in combination with surgery, surgery and observation) the frequency of metastatic spreading to the neck lymph nodes was 20, 7, 17, and 34%, respectively, and 22% for the whole group. The 5-year survival rates were 79, 50, 49, and 67%, and 61% for the whole group. The main cause of death in 40% of the patients was a primary tumor recurrence versus 17% following the other modalities.

Adult↗
PubMed1991

[The treatment procedure in olfactory (esthesioneurogenic) tumors].

In 1968-1988, eleven cases of olfactory neurogenic tumors were seen at The All-Union Center for Oncology Research, Moscow which made up 9.5% of the total of nasal cavity cancers. Morphologically, esthesioneurocytoma was diagnosed in two patients whereas esthesioneuroblastoma--in nine. Four patients received combined therapy while seven--chemotherapy and radiation. Progression of the disease was registered in 7 out of 11 patients: in 3 of 4 cases receiving combination treatment and in 4 out of 7 those treated conservatively. Four cases died within 7-29 months while 7 remain alive: two patients at 18 and 156 months following combined therapy and 5--at 18, 18, 24, 84 and 132 months after chemoradiation treatment. Radiation alone proved the best therapeutic option. Surgery is justified in cases with residual tumor as second-line procedure.

Adolescent↗
PubMed1990

[Comparative evaluation of radiotherapy and chemoradiotherapy in inoperable cancer of the esophagus].

The paper is concerned with the results of radiation therapy and three variants of chemoradiotherapy of 174 patients with inoperable esophageal cancer. Altogether 151 (87%) patients were given treatment from beginning to end. Complete tumor regression was noted in 41% of the patients after chemoradiotherapy and in 29%--after radiotherapy. The 2-year survival rates were 28 and 20%, the 5-year survival rates were 8 and 0%, respectively. Among the variants of chemoradiotherapy the most effective one was the combination of 5-FU with bleomycin, in which complete tumor regression was noted in 46% of the patients, and the 2-year survival was 43% versus 25% in the combination of 5-FU with adriamycin and 21% in its combination with methotrexate. Prognostically unfavorable factors were a degree of body mass deficiency, tumor spreading and a tumor site in the esophagus.

Adult↗
PubMed1990

[Long-term results of complex and combined treatment of locally advanced cancer of the oral mucosa].

The analysis of data on 93 cases of stage III-IV cancer of the oral mucosa showed the superiority of combined treatment over complex in terms of five-year survival: 47 and 20%, respectively (p less than 0.01). However, no significant difference in respect to that parameter was established between the combined treatment group and patients rendered disease-free with complex therapy: 47 and 40%, respectively (p greater than 0.05). In the whole group studied, five-year survival rate was 32 +/- 5%; it was 37 +/- 6 and 25 +/- 7% in patients without and with regional lymph node metastases, respectively.

Adenocarcinoma↗
PubMed1989

[Hyperfractionated irradiation of malignant head and neck tumors].

A comparative analysis of results with hyperfractionated tele-gamma-irradiation was done in 75 patients with locally advanced head and neck tumors (mainly stage III-IV) with different partition of the daily dose. The patients were divided among three groups. In group I (33 patients) the radiotherapy was carried out with 1.2 Gy (twice a day with an interval of 6 hours) up to the total dose of 70 to 75 Gy, in group II (23 patients) the irradiation took place with 1 Gy (three times a day with a 3-hours-interval between the fractions) up to the total dose of 60 to 65 Gy; in group III (19 patients) 1 Gy was given (five times a day) with the total dose of 60 Gy. Good perspectives followed for hyperfractionated irradiation with two or three times repeated partition of the daily dose, in which the frequency of complete tumor resorption was 94 to 95% and the two-years-survival attained 60.6 or 77.3% in the analysed groups without late complications.

Adult↗
PubMed1988

[Prognosis of survival time in year prior to the start of radiotherapy of epidermoid carcinoma].

The results of radiation therapy of 117 patients with squamous cell lung carcinoma taking into account yearly survival were analyzed. Clinico-laboratory and roentgenological factors of prognosis were identified. The use of methods of mathematical statistics and a method of structural risk minimization made it possible to work out a decision rule permitting prognosis of yearly outcome of disease with the minimal probability of 72% even before the start of radiation therapy.

Adult↗
PubMed1988

[Assessment of different variants of hyperfractionated irradiation in cancer of the naso- and oropharynx and of the oral mucosa].

The authors presented comparative analysis of the results of hyperfractionated gamma-irradiation of 75 patients with locally advanced head and neck tumors (stages II-IV) in various types of daily dose fractionation. 33 patients of the 1st group received radiotherapy at a dose of 1.2 Gy twice a day at a 6h-interval up to a total dose of 70-75 Gy, 23 patients of the 2nd group were irradiated at a dose of 1 Gy 3 times a day at a 3h-interval up to a total dose of 60-65 Gy, 19 patients of the 3rd group were irradiated at a dose of 1 Gy 5 times a day up to a total dose of 60 Gy. The authors have shown the prospects of hyperfractionated irradiation with two- and threefold daily dose fractionation in which complete tumor resorption was 94-95%, the 2-year survival was 60.6 +/- 7 and 75%, respectively without signs of late complications.

Adult↗
PubMed1987

[Comparative evaluation of the effectiveness of radiotherapy and chemo-radiotherapy of stage III-IV nasopharyngeal cancer].

The paper is concerned with the results of radiation and chemoradiotherapy of stage III-IV rhinopharyngeal cancer. Short- and long-term therapeutic results, the time of a recurrence-free course, the frequency of recurrences and metastasizing, expression of reactions, and complications were used as criteria. The most effective method of combined therapy of locally spread rhinopharyngeal cancer was polychemotherapy (bleomycetin, methotrexate, vinblastine, and cyclophosphamide) before irradiation with subsequent maintenance cyclophosphamide chemotherapy once in 4 weeks for 3-6 months. The 5-year survival rate for combined modality therapy of stage III-IV rhinopharyngeal cancer was within 62%, for radiotherapy used alone-50%.

Adolescent↗
PubMed1986

[Postradiation pericarditis in lymphogranulomatosis patients].

Postradiation pericarditis was diagnosed in 11 of 52 patients treated for lymphogranulomatosis with radiation applied to enlarged mediastinal lymph nodes. The risk of postradiation pericarditis is greater in cases of high radiation doses (more than 45 Gy) and in patients with postradiation pneumonitis. Postradiation pericarditis can develop both during the exposure and long after radiation therapy; therefore long-term follow-up is required for these patients.

Adult↗
PubMed1986

[Combination gamma-therapy of cancer of the oral mucosa].

The authors analysed the results of therapy of 72 oral mucosa cancer patients who had received combined modality radiotherapy using at the stage of intracavitary irradiation sources of 60Co of a raised dose rate on the afterloading AGAT unit. Forty four patients received irradiation as part of combined modality therapy, 28 were treated by irradiation only. Two variants of combined modality radiotherapy were employed: gamma-beam and intracavitary irradiation was given simultaneously on the same day; consecutively alternating gamma-beam (on the 1st day) and intracavitary (on the 2nd day) irradiation. The most effective summary focal dose values in preoperative combined irradiation were 40-45 Gy (with the ratio of the contribution of gamma-beam therapeutic doses of 30-35 Gy and intracavitary doses of 10-15 Gy) and in radiotherapy used alone 75-80 Gy (with the ratio of irradiation components being 50-55 Gy and 25-30 Gy respectively). Complete tumor resorption in combined modality radiotherapy used independently was achieved in 19 out of 28 patients (67.8%). In combined treatment tumor regression by more than 50% after preoperative irradiation was achieved in 65.9% of the patients. Tumor recurrences were noted in 5 of 44 (11.3%) patients in combined treatment and in 3 out of 19 (15.7%) in radiotherapy used alone. Five-year survival rates calculated with the help of life tables were 55.7 +/- 10% after combined treatment and 48.7 +/- 11% after radiotherapy used alone. Clinical evidence indicated the advantages of combined modality radiotherapy with simultaneous intracavitary and gamma-beam irradiation.

Adult↗