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Biomedical subjects

B M Aliev

Publications and source records attributed to B M Aliev.

At least 37 records · Page 2Linked to original sources
PubMed1985

[Radiotherapy and combined chemo- and radiotherapy of patients with squamous cell lung cancer (randomized study)].

A randomized study on the results of treatment of 76 cases of squamous cell carcinoma of the lung was conducted at the Center in 1976-1981. Radiation and chemoradiation procedures were studied in two groups of patients. The immediate results of chemoradiation therapy were somewhat better as compared with radiation treatment alone. However, no significant increase in survival rates was recorded. The toxicity of the chemotherapeutic procedures used was shown. Total focal dose was increased to 90-120 Gy and longer survival was registered as a result of consistent application of uneven irradiation and open fields in gamma therapy.

Adult↗
PubMed1984

[Effectiveness of combined and complex treatment of patients with operable cancer of the rectum].

Three hundred and eleven cases of rectal cancer received treatment according to the protocol of a cooperative randomized study. Preoperative irradiation improved three-year survival rates, particularly, in node-negative patients. In node-positive patients, frequency of relapse dropped from 30.0 +/- 8.5 to 5.7 +/- 3.9% when surgical treatment was supplemented by pre- and postoperative irradiation or drug therapy.

Adenocarcinoma↗
PubMed1984

[The 5- and 10-year survival and long-term effects of radical radiotherapy in patients with stage I-III Hodgkin's disease].

Radical radiation treatment was given to 152 patients suffering from stage I-III Hodgkin's disease in 1967-1977. Exposure was limited to the lymph collectors above the diaphragm in cases of stage I tumor. Exposure was extended to para-aortal lymph nodes and spleen (or splenic base) in cases of stage II tumor. All three levels were irradiated in cases of stage III. Mean five-year survival rate in the entire group was 89% (stage I-93: IIA-92.8 and IIIA-82.3%); ten-year rate-66.6%. Recurrences were detected in 43.5%; 75% of them were identified within the first two years after radiation. Relapse was more frequent in cases of mixed cell pattern of tumor and lymphoid depletion. Radiation-induced injuries of varying degree were found in 28%, changes in the lungs and soft tissues were prevalent. A relationship between radiation injury frequency and the extent of exposure was established: radiation injury was observed in 4% of stage I cases and in 63% of patients with stage III tumor. Radiation-induced malignancies (breast cancer and fibrosarcoma of ilioinguinal soft tissues) were found in two cases out of 152 at different periods of the study.

Adolescent↗
PubMed1983

[Combination treatment of rectal cancer using 2 variants of preoperative concentration gamma therapy].

The paper is concerned with the results of a randomized study of 154 patients with rectal cancer. Of these, 76 were on combination therapy and 78 underwent surgical treatment alone. Preoperative gamma-therapy was given from open fields at a single dose of 4-5 Gy with a summary dose of 20-25 Gy, or by using a grid diaphragm at a single dose of 10 Gy up to a summary dose of 50 Gy. Irradiation was followed by surgical intervention in 3-5 days. The analysis of immediate therapeutic results has shown that the above variants of preoperative irradiation are well tolerated and do not cause an increase either in the number of postoperative complications or lethal cases. Combination therapy improves long-term results and causes a significant decrease (more than thrice) in the frequency of postoperative cancer recurrences. The treatment has proved to be the most effective in patients with a locally disseminated process and an unfavorable prognosis.

Adenocarcinoma↗
PubMed1983

[Computerized tomography in planning radiation therapy of patients with nasopharyngeal squamous-cell cancer].

In 27 patients with squamous cell nasopharyngeal cancer, the results of a routine x-ray study were correlated with those of computerized tomography. It has been shown that the resolution of computerized tomography is about twice as high in specified diagnosis of a disseminated tumor process, particularly in cases when the tumor involves the orbit, retrobulbar space, pterygopalatine fossa, uncinate processes, nasal cavity, etc. Besides, computerized tomography can de effectively used to correct irradiation conditions during radiation therapy and to evaluate therapeutic results.

Adolescent↗
PubMed1983

[Twice daily irradiation of nasopharyngeal lymphosarcomas and cancer].

The authors present the preliminary results of double daily irradiation with a 4-hour interval of patients with rhinopharyngeal cancer (30 persons) and lymphosarcoma (18). This irradiation variant was well tolerated; all the patients received radiotherapy in accordance with the plan of irradiating tumors with mean focal doses of 70-76 Gy for rhinopharyngeal cancer and 40-50 Gy for lymphosarcoma. Complete tumor regression by the end of radiotherapy was achieved in 75%, partial in 25% of patients with rhinopharyngeal cancer. In lymphosarcoma, these figures were 80 and 20%, respectively. No late injuries of the normal tissues after 6-36 months were noted in patients.

Adolescent↗
PubMed1983

[Method of gamma teletherapy in prostatic cancer].

Three variants of gamma-beam therapy of prostatic cancer were worked out on the basis of a thorough topometric preparation, an analysis of dose distributions using computer, and taking account of tumor dissemination. It has been shown that moving one- or two-field gamma-beam therapy is indicated in cases when tumor lies within the limits of the prostate only. When it affects regional lymph nodes the combination of moving gamma-beam therapy with static 4-field cross irradiation with the ratio of doses from the front and back fields 2:1 is recommended. When tumor involves the nearest lymphatic collectors gamma-beam therapy is supplemented by estrogens with stage-by-stage irradiation of primary tumor, regional lymph nodes (by the above schemes) and the paraaortal group of lymph nodes from 2 opposite shaped fields, a focal dose to these nodes being 30-40 Gy only. The summary focal dose to the regional lymph nodes is 45-50 Gy, to primary tumor 65-70 Gy. The above variants of gamma-beam therapy were used for the treatment of 69 patients with prostatic cancer, Stages II-IV. Not a single patient developed marked reactions and late complications 6-36 mos. after therapy, 61% of the patients lived over 3 yrs.

Gamma Rays↗
PubMed1982

[Late results of the combined treatment of locally disseminated soft tissue sarcomas].

Radical surgery was performed in 69 cases of primary and recurrent localized soft-tissue sarcomas (extended dissection of tumor--53, exarticulation or amputation--16) after a course of non-uniform irradiation, when other methods of specific treatment had failed. Areas of exposed tumors were irradiated with focal doses of 90-120 Gy, screened areas--with 40-60 Gy. Radiation was delivered through a latticed diaphragm from the same field. Postoperative complications due to intensive irradiation and radiation injury were comparable to those involved in standard radiation procedures. A 5-year survival rate was 50% (primary tumor--16 and relapse--77%).

Adult↗
PubMed1981

[Clinical trial of a variation of combined radiation therapy of recurrent rectal cancer in women].

The results of clinical testing of the variant of associated radiotherapy for recurrent rectal cancer in 34 female patients are reported. Distant grid gamma therapy in the regime of uneven irradiation was associated with intracavitary irradiation and gammatherapy from open fields. An average focal dose under uneven irradiation was 86 Gy (8600 rad) in intracavitary gammatherapy--30 Gy (3000 rad), in open field irradiation--30 Gy (3000 rad), the radiation stress being 1.5-2 times increased within the limits of normal tisues tolerance compared with routine variants of irradiation. No marked radiation injuries hampering the continuation of the treatment were observed in the period to follow. Among 34 patients in 8 (23.5%) the complete tumor regression was gained.

Adenocarcinoma↗