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Biomedical subjects

B M Kogan

Publications and source records attributed to B M Kogan.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Catecholamine levels in the striatum, hypothalamus, and adrenals of rats with genetic predisposition to epileptic seizures].

The content of catecholamines (CA) was studied in the basal ganglia, hypothalamus and adrenals of Krushinsky-Molodkina (KM) rats exhibiting the increased sensitivity to convulsants, and of non-audiogenic Wistar rats. It was found that in all the structures under test the content of CA was considerably higher in KM than in Wistar rats. At the same time the concentration of dopamine in the basal ganglia and hypothalamus was far greater than that of the subsequent reaction products (noradrenaline, homovanillic and dioxyphenyl acetic acids), and the concentration of dopamine in the adrenals exceeded that of noradrenaline and adrenaline. Excess dopamine in the basal ganglia seems likely to be the reason for the failure of caudate nucleus inhibitory function in KM rats, thereby contributing to the increased sensitivity of the animals to convulsants. The relationship between the sensitivity to stressors and the initial level of CA metabolism is discussed.

Adrenal Glands↗
PubMed1982

[Importance of a comprehensive instrumental assessment of cardiovascular system function for the expert medical work evaluation of ischemic heart disease patients].

A total of 103 patients with ischaemic heart disease (IHD) were investigated 1 1/2 to 10 years after myocardial infarction. The functional state of the cardiovascular system was studied with the aid of electrocardiography, tetrapolar chest rheography and spiroergometry in the bicycle ergometric test. This test revealed ischaemic shifts on the ECG in 63% of patients with IHD. Patients with IHD, as compared to the control group of normal individuals, showed lowered tolerance to exercise and shifts in the indices of the central haemodynamics and gaseous exchange, including less manifest increase of the stroke and minute volume of blood, and oxygen consumption. The results of the study permitted the authors to diagnose the initial state of the cardiac insufficiency and to graduate the functional possibilities of the cardiovascular system in patients with IHD. It is recommended to use such a comprehensive cardiological study of the functional state of the cardiovascular system for medical assessment of the working capacity of IHD patients.

Adult↗
PubMed1982

[Effect of cholecystokinin on dopamine metabolism in the rat brain].

The effect of sulfated octapeptide of cholecystokinin (CCK) on dopamine turnover was examined in different parts of the rat brain. It was demonstrated that CCK administered intrapeutoneally in doses of 5, 15 and 30 micrograms/kg significantly increased dopamine turnover in the amygdala, and nucleus accumbeus, without changing dopamine turnover in the midbrain, hypothalamus and striatum. The data suggest that variation in the activity of the mesolimbic dopamine system might be one of the mechanisms by which CCK regulates the animals behavior.

Animals↗
PubMed1981

[Various features of dopamine metabolism in schizophrenia].

Peculiarities of dopamine metabolism were investigated in 27 patients with various forms of active schizophrenic process. The investigations were carried out by determining the content of dopamine and its metabolites in the blood and urine. In all the patients a considerable rise of the dopamine blood level (284.7 of normal) was revealed: prevalent were bound forms of this amine. The free dopamine content in the blood rose still higher in cases of psychomotor excitation. The dopamine content in the patients' urine was lowered. The determinations of dopamine metabolites, such as, dihydroxyphenylacetic acid, and homovanillic acid showed an insufficiency of dopamine deamination: this was an evidence of a deficient activity of monoamine oxidase. Administration of L-DOPA to schizophrenic patients did not cause a rise of the dopamine blood level (in distinction from normal). The author suggests that the discovered disturbances of dopamine metabolism play a certain role in the pathogenesis of schizophrenia.

Dihydroxyphenylalanine↗
PubMed1980

[Importance of corrected electro- and vectorcardiogram leads for the expertise of the work capacity of ischemic heart disease patients].

The bioelectrical activity of the heart was studied in 126 patients with ischemic heart disease according to the data of corrected orthogonal electro- and vectorcardiogram from the standpoint of employing the findings in expert medical assessment of the working capacity of patients with this disease. Advantages of the vectorcardiogram in the diagnosis of the initial forms of ischemic heart disease and cicatricial myocardial lesions were shown. The results obtained provide evidence that the use of the vectorcardiogram contributes in some cases to the precise diagnosis and, therefore, to the proper solution of the problems of the working capacity of individuals with ischemic heart disease.

Adult↗
PubMed1979

[Neurochemical basis of the pathogenesis of different types of addiction].

The study is concerned with the influence of narcotic drugs of a different chemical nature (alcohol, morphine, barbamil) on the catecholamine metabolism in some areas of the brain and adrenal gland in experimental animals. Each of the studied drugs exerted a differentiated effect on the catecholamine system in the different brain structures. However all these substances both in a single administration and in a long-term use, and development of a drug dependence, evoked similar changes in the catecholamine metabolism in the hypothalamus and in the middle brain. These changes were shown by an intensified release and destruction of the noradrenalin neuromediator under the influence of the above-mentioned substances and a compensatory increases in the catecholamine synthesis on a prolonged use. Withdrawal of narcotic drugs leads to a significant increase in the dofamine level in these brain areas. The pharmacological analysis demonstrated, that the formation of a narcotic dependence may be connected with the changed functions of the catecholamine brain system.

Adrenal Glands↗
PubMed1978

Effect of drugs with addicting properties on brain catecholamines.

The effect of morphine and amobarbital on catecholamine metabolism in different regions of the rat brain (cortex, hippocampus, striatum, hypothalamus and midbrain) was studied. The investigation showed that drugs of different chemical structures but with common addicting properties evoke the same type of changes in catecholamine metabolism which are expressed by an intensification of release and disintegration of norepinephrine and by a decrease in dopamine level.

Amobarbital↗