PubMed Health⌕ Search

Biomedical subjects

B M Kogan

Publications and source records attributed to B M Kogan.

69 records · Page 4Linked to original sources
PubMedDate not supplied

[The similarity of the pathogenetic mechanisms of alcoholism and drug dependence and the means of searching for agents for treating these diseases].

The concept of the principal unity of the pivotal mechanisms underlying the formation of the syndrome of dependence on alcohol and various narcotic agents is presented. The central link of the mechanisms is the totality of the specific disturbances of neurochemical processes among which of particular importance are the specific changes in the functional state of catecholamine system. The theoretical approaches to the development of medicinal agents for treating alcoholism and drug addictions are considered. As an example there are discussed the results of using small doses of dopamine receptor stimulants (apomorphine and bromocriptine) and a neuropeptide cholecystokinin.

Alcoholism↗
PubMedDate not supplied

[Effect of bromocryptin on the alcohol consumption and catecholamine level in the brain of rats undergoing long-term alcoholization].

It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals. Reduction in alcoholic motivation correlates with normalization of the level of dopamine, decreased by chronic alcohol action in the rat hypothalamus and midbrain. The use of bromocryptin also prevents an increase in the dopamine content in the rat hypothalamus during alcohol withdrawal.

Alcohol Drinking↗
PubMedDate not supplied

[Relationship of free and conjugated forms of catecholamines in depressive disorders in psychopathic personalities].

The study was undertaken to examine the content of free and conjugated forms of norepinephrine, dopamine, epinephrine in the daily urine and blood plasma of psychopathic patients during varying severity depressive disorders. To isolate the conjugated forms, hot acid hydrolysis was applied, catecholamines were measured by the procedures based on high performance liquid chromatography with electrochemical detection. Patients with the most marked clinical signs of depressions were found to have the most profound urinary and blood shortage of free forms of dopamine and norepinephrine, as compared with the controls, which was associated with the most intensive conjugation of these catecholamines. Thus, it may be supposed that disturbances of the catecholamine conjugation systems are one of the neurochemical mechanisms underlying the development of affective disorders.

Adolescent↗
PubMedDate not supplied

[Determination of free and conjugated catecholamines, 3,4-dihydroxyphenylalanine, 3,4-dihydroxyphenylacetic acid in the urine and blood plasma by high pressure liquid chromatography].

A method for simultaneous measurement of free and conjugated forms of adrenalin, noradrenaline, dopamine, 3,4-dihydroxyphenylalanine, and 3,4-dihydroxyphenylacetic acid in the blood plasma and urine by high-pressure liquid chromatography with electrochemical detector has been developed. The levels of the said substances in 36 normal volunteers and 20 patients with mental disorders are presented. Simultaneous measurements of excretion of free catecholamines and their conjugates permitted a more complete characterization of catecholamine metabolism, which is important for understanding the mechanisms of disorders in catecholamine system in various diseases.

3,4-Dihydroxyphenylacetic Acid↗