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Biomedical subjects

B Marín

Publications and source records attributed to B Marín.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Effects of malnutrition in utero and during lactation on various parameters of the small intestine in rats].

Short and long term effects of malnutrition on the small intestine, applied to the rat in uterus and lactation, have been studied. Malnutrition was induced by feeding the pregnant rats on 14 g daily during pregnancy and 21 g during lactation. In the pups (0, 15, 30, 90 and 150 days old), body weight and wet and dry weight and length of small intestine were measured. At 2.5-3 months of age, food transformation efficiency was studied, at 3 and 5 months of age in vivo intestinal absorption of D-glucose (11 mM) was measured. The results indicate a significant decrease in intestinal morphometric parameters in malnourished animals from birth to the age of 5 months. At the age of 3 months both food transformation efficiency and in vivo absorption of glucose were significantly higher in early undernourished animals, whereas at 5 months, glucose absorption was significantly higher in control. It can thus be concluded that early malnutrition altered the small intestine development and functionality and that total recovery did not occur after 4 months on a normal diet.

Animal Nutritional Physiological Phenomena↗
PubMed1987

Malnutrition in rats during pregnancy and lactation period: a study on body, spleen and thymus weights and hematologic parameters in dams and their offspring.

Physiological changes in the rat dams and their offspring as sequelae of malnutrition during pregnancy and lactation and their capacity for recuperation from early malnutrition is studied. The dams were killed during the lactation period (15th and 30th days of postpartum) and the absolute and relative weights of the thymus and spleen were recorded. The following hematologic parameters were examined: red blood cell count, hemoglobin, hematocrit, mean cell volume, mean cell homoglobin, mean cell hemoglobin concentration, white blood cell count, lymphocytes, monocytes, eosinophils, polimorphonuclear neutrophil, basophils. The offspring were sacrificed at 15, 30 and 90 days of age. Their body weight and the same hematic parameters and organ weights as their mothers were determined. Results indicate a highly significant decrease in body weight and organ weights in experimental dams and an important alteration in their hematic parameters, which may be an important determinant of retardation of growth in pups, whose body and organ weights were significantly smaller than those of the controls. In addition, the hematologic parameters of the malnourished offspring were modified in relation to those of the controls at all times (15, 30 and 90 days old) studied.

Animals↗
PubMed1987

Predominant right ventricular infarction in malignant renovascular hypertension in rats.

Malignant hypertension was induced in Wistar rats of both sexes by complete aortic ligature just above the origin of the left renal artery. An acute and a late phase of hypertension, 4 days and 28 days after the aortic ligature respectively, were defined to study the relationship between the severity of hypertension and injury of the small arteries and myocardial necrosis. The most frequent finding in the heart was the presence of right ventricular infarction. In acute-phase hypertension most of the animals showed acute infarction of the right ventricle, but only focal left ventricular infarction was found. Lesions in the large coronary arteries were not observed. However, the small arteries and arterioles of the right ventricle presented fibrinoid necrosis lesions. In late-phase hypertension, the intramyocardial small vessels showed proliferative endarteritis and fibrinoid necrosis lesions, but this time they appeared in both ventricles. The severity of the myocardial infarcts and the percentage of small arteries and arterioles injured in the right ventricle were significantly higher than in the left ventricle despite the maintenance of blood pressure almost to the same level. No changes in the right ventricular pressure were observed in either phase. These observations suggest that in malignant renovascular hypertension the intramyocardial arteriolar lesions appear to be an important factor in the production and the severity of myocardial infarcts with predominance in the right ventricle.

Animals↗
PubMed1986

Prenatal stress: effects on sexual receptivity in female rats.

Pregnant primiparous rats were submitted to daily immobilization stress for 3 hour periods which were increased 15 minutes every third day. A considerable increase in the receptivity to the male was observed in the prenatally stressed females versus controls. Female offspring from both groups did not show any differences in body, adrenal, ovary and brain weights.

Animals↗
PubMed1985

Influence of undernutrition during gestation and suckling on development and sexual maturity in the rat.

The effects of undernourishment during gestation and suckling on rats subsequently fed ad libitum for 4 mo after weaning are explored. We measured the following: weight at birth and over a 5-mo period; sexual behavior of adult males; curiosity; basal physical activity; morphometric measures; organ weights (absolute and relative) including brain, testicles and seminal vesicles in males 5 mo of age; and the O2 uptake of some brain and glandular structures in males at 5 mo of age. Body weight of the malnourished animals was consistently lower than that of the controls. Compared to controls sexual behavior in undernourished males was significantly reduced, while curiosity test and basal physical activity were increased. The absolute weights of all organs (except the pituitary gland) were significantly lower in malnourished males at 5 mo than in controls. Compared to controls, relative weight of brain was greater and that of seminal vesicles was less in the male rats. Oxygen uptake was significantly lower in the pituitary gland and testicles of malnourished males than of controls. In view of these results, it can be concluded that malnutrition in utero and while suckling affects fundamental parameters of both development and reproductive function in the male offspring 4 mo after feeding ad libitum is begun at weaning.

Animals↗
PubMed1985

Blood pressure changes after gastric mechanical and electrical stimulation in rats.

The effect of different stimuli applied in several parts of the digestive tract on blood pressure was studied in unconscious Wistar rats. Gastric distension and electrical and pinching stimuli produced a significant increase in both systolic and diastolic arterial blood pressure. When different gastric zones were stimulated by either electrical or pinching stimuli, the highest pressor response was found in the antropyloric zone. The stimuli applied to the small intestine, outside the duodenum, did not modify the blood pressure. The pinching of the abdominal peritoneum caused a pronounced (P less than 0.001) blood pressure decrease. These data suggest that the pressor response to gastric distension could be mediated by gastric mechanoreceptors. The pressor response observed after stimulation of the gastric antropyloric zone suggests that this area has a greater number of mechanoreceptors.

Animals↗
PubMed1985

[Oxygen consumption in nerve centers. Effect of cyproheptadine hydrochloride on normal and alcohol-treated rats].

The effect of CLH-CP (Cyproheptadine Chlorhydrate) on the oxidative activity of the nervous centers involved in the control of ingestion: hypothalamus, anterior cortex, amygdala and septal area, has been studied in normal and alcoholized male rats. The statistical analysis of the results showed that O2 consumption decreased significantly with CLH-CP in all studied structures except the hypothalamus in the alcoholized group, whereas no modification of O2 consumption in the normal group had been observed after treatment with CLH-CP, which may be related to the assayed dose. There are further significant differences in O2 consumption between normal and alcoholized groups without treatment with CLH-CP, the O2 consumption being significantly higher in the latter group and in all the studied structures except the hypothalamus where the O2 consumption significantly decreased in the alcoholized group as compared to the normal group. These latter differences disappeared when the structures of both groups were treated with CLH-CP. On the basis of these observations the results of the CLH-CP effect in both animal groups are discussed.

Amygdala↗
PubMed1985

[Effects of thyroidectomy and submaxillary sialoadenectomy on physiological parameters in the female rat].

The effects of interaction of the thyroid function with the submaxillary glands on the female rat, on the body growth, weight evolution of adrenal glands, ovary and parotid glands, puberty onset, estrous cycle, fertility, gestation and offspring size, plasmatic levels of glucose, glucagon, Na+, K+ and total protein have been studied. The effects of sialadenectomy and thyroid function are both independent in all parameters, except in ovary growth, which is depressed by thyroid function when submaxillary glands are removed, and in circulating glucose, since sialadenectomy stabilizes to hypoglycemia which results from thyroidectomy.

Animals↗
PubMed1985

[Effects of immobilization stress in utero on the course of pregnancy in the rat and on various parameters in the newborn animals].

The effects of immobilization stress applied during pregnancy on the evolution of pregnant rats and on the fetus and newborn have been studied. Results show alterations in food intake during pregnancy as well as in the weight of some measured structures in 21 day old fetuses. There was similarly found a significant increase in the number of dead newborn. The effect of immobilization stress applied in utero upon the evolution of pregnancy, fetus and newborn, is discussed.

Animals↗
PubMed1985

[Malnutrition in utero and lactation: relation between the weight gained by the mothers and the development of their offspring].

Physiological weight changes in rat dams and their offspring as sequelae of malnutrition during pregnancy and lactation have been studied. Daily monitoring of the body weight as well as the consumption of food (malnutrition dams 14 g during pregnancy and 20 g during lactation) and drink in control and malnutrition dams was conducted. The number of pregnant dams that completed their pregnant period successfully was registered as well as the number and weight of the pups at birth and their evolution over a period of a month. The percentage of mortality of the pups during that period has been studied. The present results indicate a highly significant decrease in body weight in experimental dams, which determines a retardation in the physiological development of the pups, and yields a higher percentage of mortality in the experimental animals than in controls. It can thus be concluded that malnutrition in utero and during lactation affects the ratio between weight gain for dams and the physical development of their pups.

Animals↗
PubMed1984

[Neuropsychological effects of various cerebral tumors].

We have studied in this work, from the neuropsychological point of view, sixteen patients (9 with tumor in the frontal lobe, 3 with temporal and temporo-parietal tumor and 4 with parietal, occipital and parieto-occipital tumor). The results show an intellectual damage when the work to carry out involves time, visualmotricity and perceptive-visual integration. We have likewise observed the appearance of many disorders of the spatial orientation, the perceptive visual integration, the graphomotricity and the reading process.

Brain Neoplasms↗
PubMed1982

Effect of early pre- and postnatal acquired malnutrition on development and sexual behavior in the rat.

In this paper we attempt to elucidate the effects on the rat offspring of undernourishment during pregnancy and lactation on the following parameters were examined: weight at birth and its evolution over a three-month period, sexual behavior of adult males, vaginal opening and sexual cycle of females, blood sugar, blood proteins, hematocrit, natremia, potassemia, body weight and weight of testicles, seminal vesicles and adrenal glands in males 5 months of age. Our results indicate highly significant decreases in body weight in experimental animals over a period of three months. Vaginal opening in experimental females is significantly delayed and their estrous cycle is shortened. Male sexual behavior shows decreases in neuromotor activity and prolongation of the refractory period in experimental male animals. Of the parameters monitored at 5 months of age, only blood sugar levels were significant decreased in experimental male rats. In view of these results, it can be concluded that in utero and lactation period malnutrition affects fundamental parameters of both development and reproductive function in the offspring.

Adrenal Glands↗
PubMed1982

In utero immobilization stress and its effects on the development, behavior and sexual maturity of the rat.

The effect of prenatal stress from psychophysical immobilization, the applied during gestation, has been studied as well as its consequences on the development, behavior and sexual maturity in the offspring. Modifications in development were slight, even when intensified at four months of age. Whereas male sexual behavior showed only slight variation, female sexual maturity was markedly changed in experimental animals as compared to controls. From the present results, the psychopathological action from immobilization stress in utero on offspring is questionable.

Animals↗
PubMed1978

Sex difference in polyethylenglycol-induced thirst.

The polyethylenglycol-induced thirst in male and female castrated rats has been studied. The polyethylenglycol (PG) increases the water intake more in females than in males. Estradiol benzoate and testosterone P. diminishes the amount of water drunk after PG treatment in the females, but not in the males.

Animals↗