[Surgical treatment of achalasic megaesophagus with myotomy and the Dor fundoplication. Long-term results].
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Biomedical subjects
Publications and source records attributed to B Micali.
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Bombesin, administered by intravenous infusion (5 ng . kg-1 . min-1) for 60 min, significantly delayed gastric emptying of solids in man and strongly potentiated the gastrin response to food. However, no correlation was found between the difference in the integrated gastrin response (to meal and to meal plus bombesin) and the degree of delay in emptying. The effect of the peptide is most likely connected with the strong contraction of the gastroduodenal junction pinpointed in previous investigations.
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This study covers 14 patients subjected to truncal Vagotomy + Antrectomy acc. BI, in order to ascertain whether somatostatin is capable of inhibiting duodenal gastrin release. Somatostatin infusion significantly inhibits the gastrinic response to a protein meal, but does not affect basal levels of the hormone. This suggests that facilitation of duodenal gastrin release after vagal section may be mediated by the reduced somatostatin release.
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On the basis of acquired experience, the Authors report on the usefulness, during pre-operative diagnosis, of making specific instrumental and histopathological investigations for evaluation of parotid tumours, so that the most adequate therapeutic action can be planned.
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Intravenous infusion of bombesin (5 ng.kg(-1). min(-1) significantly delayed gastric emptying of solids in man. The gastrin response to meal increased following administration of the peptide; however no correlation was found between the difference in gastrin response (to meal alone and to meal plus bombesin) and the degree of delay in emptying. In addition the behavior of intragastric pH after eating was not modified by bombesin infusion. All of these data suggest a direct effect of the peptide on gastric emptying, which was probably connected with the strong contraction of the antrum and pylorus observed in this and in previous investigations.
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The therapeutic action of Triazolam has been assessed against a placebo by administering the two substances on a double blind basis the evening prior to surgery. The results show that Triazolam was significantly better than the placebo as regards induction time and the duration and quality of sleep. There were few unimportant side-effects.
The intrasplenic autotransplant of pancreatic fragments in dogs subjected to total pancreatectomy can prevent diabetes as it maintains normoglycaemic condition and a normal insulinaemic response to i.v. infusion of glucose. By adopting a pancreatic tissue preparation technique which provides for a very short collagenasis digestion time (4 minutes), B cells took and normal glucidic metabolism was maintained.