Biomedical subjects
Publications and source records attributed to B Micali.
Serum immunoglobulins levels after surgery with and without anaesthesia are reported. No significant change was found after surgery without anaesthesia; significant changes of serum Ig (A,G,M) were observed in surgery with anaesthesia (60-180 m') group on day 1 following operation. This Ig decrease is probably due to a reduced immunologic response by long anaesthesia.
A recently observed case of T.B. of the breast is presented and the relevant literature is examined. View are expressed concerning the aetiopathogenesis, diagnosis and treatment of this unusual form, particular attention being given to the difficulty of distinguishing it from carcinoma. Stress is laid on the importance of surgical management, this being indispensable for both correct diagnosis and for treatment.
Different vascular clamp methods in liver surgery have led to less complications. The aim of this study was to evaluate the results after hepatic resection involving different vascular clamping methods and liver function outcome. Our study examined 46 patients who underwent surgery for liver lesions, developed on cirrhotic and noncirrhotic livers, applying the technique of selective clamping and pedicular clamping. There was one death (1/17; 5.9%) due to postoperative liver failure which occurred in a cirrhotic liver patient who underwent left hepatectomy with pedicular clamping. Complication rate was higher, but not significant (4/7; 57.1%) in the group with selective clamping compared to those with pedicular clamping (3/10; 30%). Hemorrhagic complications were observed in a higher rate among patients with selective clamping (3/7; 42.9%) compared to those with pedicular clamping (1/10; 10%). Selective clamping seems to find major indications in patients with chronic liver disease undergoing minimal hepatic resections. Intermittent pedicular clamping seems to be more effective in regards to blood loss and postoperative hepatic function.
Laparoscopic cholecystectomy is the suitable treatment for symptomatic cholelithiasis, even if the incidence of biliary lesions following this procedure may be up to threefold higher than that of open cholecystectomy. We report our experience concerning the incidence, aetiopathogenesis, diagnosis and treatment of complications in a homogeneous group of laparoscopic cholecystectomies. In a total of 492 laparoscopic cholecystectomies only three bile duct lesions were observed (0.6%); they were classified according to Bismuth and re-assessed according to Strasberg. They consisted in two biliary leakages and one bile duct stricture. All patients were evaluated by full blood test, ultrasonography and endoscopic retrograde cholangiopancreatography. Endoscopic treatment was successful in the two patients with biliary leakage, while the patient with a stricture required surgical therapy. In conclusion, we suggest that a correct knowledge of the aetiopathogenesis together with a multidisciplinary approach to the diagnosis appear to be the best method for the detection, complete classification and most suitable treatment of symptomatic cholelithiasis.
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Personal experience acquired in a series of 130 papillo-sphincterotomies carried out over a five-year period for the treatment of lithiasis of the VBP and benign stenosis of the papilla is reported. An account is given of the literature data showing that his method, which is comparable with biliodigestive anastomosis techniques, is safe and reliable. Attention is also drawn to its undoubted advantages in the prevention of some serious late complications.
The surgical goal of gastroesophageal reflux treatment is to restore the ability of antireflux barrier. The basal tone and the length of lower esophageal sphincter are commonly considered the most important factors in the assessment of gastroesophageal reflux symptoms. However, reflux symptoms may also occur after surgical correction of sphincter incompetence. In the present study, 20 patients were evaluated pre- and postoperatively by 24 hours pH monitoring, esophageal manometry, endoscopy and analysis of gastric emptying of solids, in order to verify surgical results and connected functional changes. Preoperative data suggested to perform a partial fundoplication in 12 patients and a total fundoplication in 8 cases. Our results can indicate that fundoplications are able to significantly control reflux symptoms, to improve the competence of lower esophageal sphincter and finally to normalize gastric emptying of solids. This study emphasizes the value of normalizing a delayed gastric emptying to assure a satisfactory clinical outcome. The postoperative impaired gastric emptying rates in fact appear to associate with persistent symptoms.