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Biomedical subjects

B Morin

Publications and source records attributed to B Morin.

At least 55 records · Page 3Linked to original sources
PubMed1982

Increased exercise tolerance and reduced electrocardiographic ischemia with diltiazem in patients with stable angina pectoris.

Diltiazem is a calcium slow-channel blocking drug that may be effective in the treatment of chronic stable angina pectoris. To evaluate the therapeutic efficacy 3 hours after a single oral dose of 120 mg, 12 men with chronic stable angina pectoris performed a maximal exercise test on a bicycle ergometer after ingesting either placebo or diltiazem administered in a double-blind fashion. During submaximal exercise at a fixed work load, diltiazem decreased the average heart rate response from 119 +/- 17 to 107 +/- 14 beats/min (p less than 0.01), systolic blood pressure from 182 +/- 15 to 175 +/- 15 mm Hg (p less than 0.05) and the rate-pressure product from 21.8 +/- 4.2 to 18.8 +/- 3.2 x 10(-3) units (p less than 0.01). The average submaximal work load at which significant ST-segment depression (0.1 mV) first appeared was increased from 355 +/- 142 to 525 +/- 143 seconds (p less than 0.01) after diltiazem. At peak exercise after diltiazem, the average depth of ST-segment depression in any one lead and the extent of myocardial ischemia observed in all 12 ECG leads were decreased (p less than 0.01), even though the average work load was increased by 29% (p less than 0.01). Peak heart rate, systolic blood pressure and rate-pressure product were similar with placebo and diltiazem. The plasma diltiazem concentration was 13.9 +/- 29 ng/ml 3 hours after ingestion and was significantly (p less than 0.05) related to the increased time to the onset of important ST-segment depression (r = 0.65) and to the decrease in the extent of myocardial ischemia observed in all 12 ECG leads (r = -0.61) compared with placebo. Thus, diltiazem is effective in treating chronic stable angina pectoris. It decreases myocardial oxygen requirements during upright exercise and appears to increase myocardial oxygen delivery.

Angina Pectoris↗
PubMed1982

[Changes in heart rate and blood pressure in a series of normotensive subjects before and after beta-blocker treatment (double-blind) during physical, dynamic, static and psychosensorial stress].

23 normotensive subjects in good health are submitted to a "test de l'exposé" and 17 others are submitted to a test on an ergometric bicycle and a hand grip stress test. These tests are performed twice at one week interval, with or without treatment with acebutolol, in double blind. HR,SBP and DBP are measured simultaneously before, during and after each test. Every stress is responsible for a marked increase in the parameters according to different modalities. With ACEBUTOLOL treatment, during the test described and during dynamic stress on ergometric bicycle, HR and SBP are always less elevated. The decreases are dependent either on the stress level or on the reactivity of the subjects. DBP is however basely modified. Under static stress, there is a decrease in HR, in SBP, but also in DBP; actually increase in this parameter is important during this type of stress.

Acebutolol↗
PubMed1981

[Automatic measure of arterial pressure using the oscillometric method (Dynamap 845)].

The reproducibility and reliability of measurements performed with an automatic blood pressure measuring device based on the oscillometric method were assessed by comparison with the results obtained by the indirect auscultation using a mercury manometer. The results of the mean values, of the correlation between successive values and of the variation of the values of systolic and diastolic blood pressure show that the readings obtained by the automatic method are very reproducible.

Adult↗
PubMed1979

[Risks and median-term results of aortic valve replacement for calcifying aortic stenosis in 100 patients more than 70 years old].

100 patients with poorly tolerated calcific aortic stenosis underwent aortic valve replacement by the same surgical team (Starr-Edwards prosthesis: 52 cases, Bjäork prosthesis: 43 cases, Lillehei-Kaster prosthesis: 2 cases, and Hancock bioprosthesis: 3 cases) between July 1971 and April 1978. The hospital mortality was 17% and acute pulmonary oedema and cardiomegaly were poor preoperative prognostic factors. The late mortality was 14.5% with an average follow-up period of 25 months (range: 2 to 74 months). The survival rate expressed as an actuarial graph was 63.1 +/- 4% at 4 years. 90% of the patients operated move up at least one class in the New York Heart Association classification and 2/3 return to Stage I. The cardiothoracic ratio improved from 0.58 +/- 0.06 to 0.51 +/- 0.03 (p less than 0.02) and the Soko low-Lyon index from 40 +/- 13 to 25 +/- 6 (p less than 0.001). The main complication encountered at middle term was haemorrhage, observed in 17.5% patients. Comparison of the spontaneous outcome of the disease with the results of surgery favour surgical treatment of patients over 70 years old with poorly tolerated calcific aortic stenosis. The valve of choice should be the bioprosthesis when dependance on anticoagulant therapy and the associated risks of haemorrhage are taken into consideration.

Aged↗
PubMed1979

[Physiological variations of arterial pressure and heart rate in the first 5 minutes after moving from a supine to an upright position].

The physiological variations of blood pressure and heart rate were studied in the first five minutes of orthostatism in conditions identical to those encountered in clinical medicine. An increase in heart rate and diastolic blood pressure was observed from the first minute. The value of systolic blood pressure decreased as the subject got up and then rose to the value measured when lying down. At the fourth and fifth minute the three parameters were stable at significantly higher values than observed when lying down for the heart rate and diastolic blood pressure, but at an identical level for the systolic blood pressure. This study shows the necessity of measuring the orthostatic blood pressure using a precise technique which detects postural abnormalities when measured in the minute of orthostatism and which gives an assessment of the standing blood pressure when measured at the fifth minute.

Adult↗
PubMed1979

[Evaluation of an automatic device for arterial blood pressure determination : the Arteriosonde 1217].

The reproductibility and reliability of measurements made with an automatic device for measuring blood pressure was assessed with reference to the results obtained by indirect auscultation with a mercury manometer. The results of the study of the average values of the correlation between successive values, and of the variability of the values of the systolic and diastolic blood pressure show that the measurement obtained by this method are very reproducible.

Adult↗
PubMed1978

[An unusual appearance of ureteric bilharzia (author's transl)].

The authors report a case of bilharzia localised to one of the ureters in a case of double renal pelvis and ureter. The parasitic infection was identified only at the time of exploratory surgery (laboratory investigations and preoperative endoscopy negative). The "providential" double ureter made it possible to combine excision of the pathological ureter with a termino-lateral anastomosis between the lower renal pelvis and the ureter of the upper renal pelvis. The result remains very satisfactory with a follow-up of 13 months.

Adult↗
PubMed1977

[Myocardial infarction following administration of oral contraceptive agents. 3 cases].

The authors report the cases of three women aged 23, 24 and 28 years, receiving oestro-progestational agents and suffering a myocardial infarction. 25 cases in the literature are reviewed. Infarction is in most cases the first symptom. The clinical picture has no special features other than the frequency of anterior localisations. Coronary arteriography carried out in 15 cases showed a lesion of one vessel in 10 patients. The most common finding was a thrombosis of the left anterior descending. The coronaries were almost of completely normal in 3 cases, diffuse lesions being found only in 2 patients. The long term prognosis, at first sight favourable since the problem is one of localised lesions, is worsened by the frequency of ventricular contraction abnomalities. Myocardial infarction in patients taking oestro-progestational agents remains rare. A logical hypothesis to explain it would be a synergistic effect between the hypercoagulability induced by the drug and the risk factors in the individual patient. They are present with a frequency similar to that seen in other series of young patients with coronary disease.

Adult↗
PubMed1976

[Meningo-radiculitis following tick bite].

The authors report nine cases of acute inflammatory polyradiculoneuritis developing one to eleven weeks after a tick bite, regressive, painful and asymmetrical, with an albumino-cellular reaction in the CSF. They stress the very particular physiognomy of this type of meningo-radiculitis, its seasonal occurrence and the uncertain nature of its pathogenesis.

Acute Disease↗