We report a case of drug-related segmental colitis in a 70-year-old woman with no thromboembolic risk factor. Mesenteric angiography showed multiple stenoses and occlusions of the distal arterial circulation in the sigmoid and descending colon. These observations support the hypothesis of an ischemic origin for this type of colitis.

Aged↗

PubMedDate not supplied

Type I benzophenone-mediated nucleophilic reaction of 5'-amino-2',5'-dideoxyguanosine. A model system for the investigation of photosensitized formation of DNA-protein cross-links.

5'-Amino-2',5'-dideoxyguanosine has been synthesized in order to investigate the intramolecular reactivity of an amino group toward the guanine radical produced by type I photosensitization mechanism. Benzophenone-mediated photosensitization of 5'-amino-2',5'-dideoxyguanosine in aerated aqueous solution results in the formation of a predominant cyclic nucleoside together with an unstable nucleoside precursor. The two modified nucleosides have been isolated by reverse phase high performance liquid chromatography and characterized by spectroscopic measurements including 13C and 1H NMR, fast atom bombardment mass spectroscopy, and UV absorption. The stable photoproduct has been identified as 9-oxa-2,4-diazabicyclo[4.2.1]non-2-en-7-ol, 3-amino- (1R-exo), whereas its precursor has been assigned as acetic acid, [(7-hydroxy-9-oxa-2,4-diazabicyclo[4.2.1]non-2-en-3-yl)amino]oxo- (1R-exo). A reaction mechanism, involving nucleophilic addition of the sugar amino group to guanine radical intermediates, is proposed to explain the formation of the two photoproducts.

Benzophenones↗

PubMedDate not supplied

Congenital kyphosis by segmentation defect: etiologic and pathogenic studies.

Sixteen cases of type II congenital kyphosis were reviewed. As a working hypothesis, we assumed that this pathology should have a behavior similar to scoliosis due to a segmentation defect, if a true unsegmented bar existed. The analysis of different parameters including the number of levels involved, the patient's age, the degree of disc space involvement, and the site of deformity did not confirm this hypothesis. Furthermore, an experimental animal study failed to reproduce this congenital anomaly. It is our belief that kyphosis resulting from a "segmentation defect" represents a developmental defect of the perivertebral structures including the annulus fibrosus, the ring apophysis, and the anterior longitudinal ligament rather than a true intervertebral bar.

Adolescent↗

PubMedDate not supplied

Congenital glenoid dysplasia: case report in two consecutive generations.

Congenital glenoid dysplasia is a rare congenital condition of the shoulder. We report the case of a 6-year-old girl that was referred to our institution for restricted motion of both shoulders. Radiological examination revealed bilateral glenoid dysplasia. At the time of the child's examination, her mother also complained of shoulder stiffness; radiographs of her shoulders were taken and revealed that she too had glenoid dysplasia. Congenital glenoid dysplasia results from failure of development of the inferior ossification center of the glenoid fossa. Shoulder stiffness is the primary resultant disability, although it is variable. Our case is notable because we identified the dysplasia in two successive generations of the same family, although the mother was unaware she had the condition.

Adult↗

PubMedDate not supplied

Surgical treatment of anterolateral rotatory instability. A follow-up study.

Anterolateral rotatory instability in 31 acutely injured knees and 31 chronically unstable knees was surgically stabilized with a previously unreported method of iliotibial band tenodesis. The anterior cruciate ligament was stretched, torn, or absent in all 62 knees. Thirty-one patients, 20 with acute injury and 11 with chronic instability, were reviewed at a minimum of 2 years. A meniscal tear was present in 80% of the acute and in 91% of the chronic injuries. The anterior cruciate ligament was repaired, in addition to the iliotibial band tenodesis in 16 of the 20 acute injuries; there was no difference in the overall results between those repaired and not repaired. The evaluation of the patients was based on four subjective criteria (including functional parameters) and five objective criteria. Ninety-three percent of the patients had returned to competitive or recreational athletic activities involving cutting or pivoting movements. Both subjective and objective results were excellent or good in 93.6% of the patients. These results, based on our evaluation, warrant continued use of this procedure, according to the prescribed indications and technique.

Adolescent↗

PubMedDate not supplied

[Value of qualitative keratometry for the correction of postoperative astigmatism].

The use of a per operative qualitative Keratometer is of interest in prevention of astigmatism in cataract extraction. Our study, which included two groups of forty patients each, demonstrated that the Karickhoff Keratometer can markedly decrease the degree of immediate post-operative astigmatism = gain of 2.38 delta in comparison with the control group and astigmatism less than or equal to 2 in 35% of the cases.

Astigmatism↗

PubMedDate not supplied

[Ocular implantation and exfoliative syndrome].

Operative difficulties and post operative complications after posterior chamber lens implantation are described in 27 eyes with exfoliation syndrome, 8 simple exfoliation syndromes and 19 capsular glaucoma. 14 eyes were operated on by extracapsular extraction and posterior chamber lens implantation in the capsular bag; 13 eyes had extracapsular cataract implantation combined with trabeculectomy. Operative difficulties were due to bad mydriasis and zonular laxity. There was no zonular dialysis. Post-operative visual acuity was between 20/40 and 20/20 in 70% of the cases. There was nos lens luxation. Intercapsular implantation is possible without great risk. The risk of zonular rupture occurs principally during extracapsular extraction. Implants 4 to 12 times Lighter than a cataract human lens do not seem to be dangerous when there is no peroperative zonular rupture.

Aged↗

PubMedDate not supplied

[Implantation in severe myopia cataract].

Based upon biometric and statistical analysis of 163 eyes (26 mm or longer), it appears that high myopia cataract occur all the earlier as the eye is long; on average, these were operated on ten years earlier than cataracts in the general population. Extra-capsular extraction and intercapsular implantation were generally used. Pre and post-operative complications are remarkably rare for such abnormal eyes. After a mean period of 22 months, detachment of the retina was observed in 1.84% of patients and secondary capsulotomy performed in 8%. Because they prevent secondary capsular opacification and anterior vitreous propagation, it appears that such barrier-type implants should be systematically placed. Current large-diameter implants allow for vitreoretinal observation. Based upon this patient population, a formula for implant power calculation specific to high myopia has been elaborated. The desired degree of refraction varies with age and patient activity.

Aged↗

PubMedDate not supplied

[Rheumatoid arthritis and hyperthyroidism. Apropos of the association of rheumatoid arthritis and toxic adenoma].

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Arthritis, Rheumatoid↗