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Biomedical subjects

B Musiatowicz

Publications and source records attributed to B Musiatowicz.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Histologic grading of malignancy and prognosis in laryngeal neoplasms].

The semi-quantitative grading system for squamous cell carcinoma based on estimation of multiple histologic variables according to Jakobsson is presented. Selected histologic parameters have been also evaluated regarding their importance in predicting patient outcome. Features such as differentiation of the tumor cells, their nuclear polymorphism, number of mitoses and vascular invasion significantly correlated with clinical outcome. The structure of the tumor and cellular host response had no influence on survival. There was statistically significant relationship between the patient outcome and histologic grade of malignancy expressed by total point value. The incidence of cervical node and distant metastases was three times more frequent in the group of poorly differentiated tumors than in others. There was no correlation found between the localization of the tumor and the degree of cancer differentiation, but the supraglottic tumors poorly and moderately differentiated infiltrated towards the glottis more often then highly differentiated.

Adult↗
PubMed1992

[Free alveolar cells in experimental pulmonary emphysema. I. Statistical analysis of cellular composition and lung morphometry].

The study was carried out on an experimental papain induced model of pulmonary emphysema. The authors assessed the cell populations sampled with lavage. Special emphasis was directed on alveolar macrophages and neutrophils. Extent of emphysema was analysed morphometrically. The authors demonstrated an influx of neutrophils 24 hours after papain was introduced intratracheally. This was followed by a swift decrease of the number of sampled neutrophils. Seven days latter the neutrophil count returned to normal. A significant increase of alveolar macrophages was seen on the seventh day. The increased macrophage count correlated with the extent of the pulmonary emphysema destruction.

Animals↗
PubMed1992

[Free alveolar cells in experimental pulmonary emphysema. II. Morphological studies of cells and analysis of their adhesive properties].

Morphological analysis of cells sampled by lavage from alveoli was carried out. Analysis of their adherent properties on a nylon filter was also studied. Morphological analysis was carried out by light and scanning electron microscopy (SEM). The authors have demonstrated a correlation between adherence of the cells to the filter and morphological characteristics of the cells. SEM disclosed a very rich configuration of the cytoplasmatic membrane and/or formation of philopodia and pseudopodia. These results correlated with the extent of emphysemic pulmonary changes. Light microscopy showed a thin veil formed by the cell membrane in cells showing highest adherent properties.

Animals↗
PubMed1989

[Primary malignant lymphomas of the digestive tract. Morphologic and clinical analysis of 100 cases].

The morphologic and clinical evaluation of malignant lymphomas having the primary localization in the digestive tract has been presented. The analysis of particular cases involved the localization of tumors, the histological types, age, sex and clinical symptoms. It has been stated that malignant lymphomas are rare primary malignancies of the digestive tract which develop most frequently in the stomach and their clinical course may be masked by other diseases of digestive tract.

Adult↗
PubMed1987

The enzymatic studies of the liver in acute experimental pancreatitis in dogs treated with prostacyclin (PGI2).

The liver affection in acute experimental pancreatitis (AEP) could be reflected by changes of enzymatic activity in the liver and in serum. The histoenzymatic studies of the liver of dogs with AEP of different severity and time of duration induced according to Elliott's method were performed and the constellation of serum enzymatic activities considering treatment with prostacyclin was estimated. The histoenzymatic reactions on succinic dehydrogenase, lactic dehydrogenase and alkaline phosphatase were depressed with progression of time and severity of AEP. In contrast, the reaction on acid phosphatase was augmented at the same time. Serum AspAT, AlAT and alkaline phosphatase were augmented in the later phase of AEP, but acid phosphatase and beta-glucuronidase were not significantly changed. The treatment with PGI2 limited both histoenzymatic reactions and alterations of serum enzymatic activities. These results support the significance of changes in enzymatic activities in the course of liver reaction on pancreatogenic noxa during acute pancreatitis, and suggest the protective effect of PGI2 against liver injury in this disease.

Acid Phosphatase↗
PubMed1986

Liver histology in chronic metribuzin poisoning of the guinea-pig.

Forty male guinea-pigs weighing 400-600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed congestion and obliteration of the trabecular structure of the liver. Acidophilic and vacuolar degeneration of the liver cells with signs of necrosis were also observed. Histochemical tests revealed a poorer staining for glycogen and succinic dehydrogenase and intensification of the alkaline and acid phosphatases reaction. The above findings indicate a progressive degeneration due to metribuzin of different organelles of the liver cells including nuclei, mitochondria, lysosomes, microvilli and the cytoplasm.

Animals↗