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Biomedical subjects

B O Osunkoya

Publications and source records attributed to B O Osunkoya.

At least 37 records · Page 2Linked to original sources
PubMed1976

Herpes type-2 viruses and gynaecological malignancies.

Numerous sero-epidemiologic studies have noted an association between Herpes Type 2 (HT-2) virus and carcinoma of the cervix. In a study to evaluate the role of this virus, if any, on the etiology of extra cervical pelvic malignancies in Ibadan, the prevalence of HT-2 virus antibodies was found not to be significantly different in patients with extra cervical pelvic malignancies (carcinoma of the vulva and malignant trophoblastic disease) and cases of chronic cervicitis when compared with healthy controls. It was therefore concluded that no association could be found between HT-2 virus and extra cervical pelvic malignancies.

Adult↗
PubMed1976

Choriocarcinoma in Ibadan: clinicopathologic studies.

The host tissue reaction to choriocarcinoma was studied in 81 Nigerian patients. A mononuclear cellular reaction, observed in about 42 per cent of the patients, was composed mainly of lymphocytes, plasma cells, histiocytes, and eosinophils in varying quantities around tumor deposits. No correlation was found between the survival of the patients and the intensity of the cellular reaction. Late presentation by our patients for medical advice and treatment may partly account for the relatively poor response to chemotherapy. The syncytiotrophoblast appears to play a primary role in vascular invasion by the neoplastic trophoblast.

Choriocarcinoma↗
PubMed1976

Herpes type-2 virus antibody status in groups of patients with neoplasm in Ibadan.

Various studies have associated Herpes Type-2 (HT-2) virus with carcinoma of the cervix, especially the squamous cell type. In the present study, prevalence of HT-2 virus antibodies was found to be significantly higher in patients with squamous cell carcinoma of the cervix than in cases with squamous cell carcinoma of sites other than the cervix, and other pelvic and extrapelvic malignancies (P less than 0.001). It was concluded that no association could be found between Herpes Type-2 virus and malignancies of sites other than the cervix.

Antibodies, Viral↗
PubMed1976

Herpes type-2 virus antigens in human cervical carcinoma.

Exfoliated cells from the cervices of 22 patients with histologically diagnosed squamous cell carcinoma of the cervix and from those of 24 control women were examined for herpes subtype 2 (HT-2) antigens by indirect immunofluorescence studies. This method demonstrated that cells from all the patients with carcinoma contained antigens related to HT-2 virus. In contrast, squamous cells from the cervices of 24 control women with no cervical disease and of 2 women with chronic cervicitis did not contain such HT-2 antigens. Although an etiologic role of HT-2 virus infection cannot yet be established, it is probable that such infection precedes neoplastic changes.

Adult↗
PubMed1976

Complement components in children with protein-calorie malnutrition.

Complement components of C1-C9 were estimated in children with protein-calorie malnutrition. The diagnosis of kwashiorkor and marasmus were based on clinical examination, anthropometric measurements and on biochemical estimations. The children were examined clinically and bacteriologically for any evidence of infection. All the complement components except C4 and C5 were significantly lower in children with protein-calorie malnutrition: of all the complement components C3 and C9 were the most severely depressed. C5 was the only complement component that was significantly higher in malnourished children than in normal children. Malnourished children with C-reactive protein in their serum had significantly lower values of C3 and C9 and higher values of C5 than malnourished children without C-reactive protein in their serum. During refeeding C3 was the first complement to show a significant rise. This was followed by C9. There was a fall in C5 concentration while there was no change in C4 concentration. The roles of infection, malnutrition and C-reactive protein on complement depletion are discussed.

Child, Preschool↗
PubMed1975

Antibodies to herpesvirus type 2 in carcinoma of the cervix uteri in Ibadan, Nigeria.

Carcinoma of the cervix is by far the commonest gynecologic malignancy seen in Ibadan, Nigeria. In a study aimed at investigating the role of herpesvirus type 2 (HT-2) in its pathogenesis, antibodies to HT-2 were detected by immunofluorescence above a titer of 640 in 31 (70.5 percent) of 44 women with invasive carcinoma of the cervix as compared with five (11.1 percent) of 45 healthy women of the same age group. Analysis according to histologic types of growths showed that 31 (83.8 percent) of 37 cases of squamous-cell carcinoma had antibodies above a titer of 640, whereas none of the other types (one adenocarcinoma and six undifferentiated carcinoma of the cervix) had antibodies above this titer. It was concluded that the results of the present study support the hypothesis of an association between HT-2 and carcinoma of the cervix, most especially the squamous-cell type.

Antibodies, Neoplasm↗
PubMed1975

Specific protein assays in protein-calorie malnutrition.

Assessment of serum protein concentrations in protein-calorie malnutrition was carried out by two specific immunochemical methods, the Single Radial Immunodiffusion technique and the Automated Immunonephelometric procedure. The correlation coefficient (r) between the two methods was above 0.85 for all the serum proteins assayed. The automated nephelometric assay procedure has the advantages that it is rapid and that a large number of samples can be readily processed. The system in its present form could not be readily used to quantitate proteins such as prealbumin whose serum concentration was less than 50 mg/100 ml. The single radial immunodiffusiton technique gave more consitent results for IgA estimation than the automated technique. With the exception of C4 and the immunoglobulins, all the serum proteins assayed were lower in children with protein-calorie malnutrition than in control children. During refeeding in children with protein-calorie malnutrition the first serum protein to show a significant rise was C3. This was followed by transferin, then prealbumin and lastly albumin. C4 did not show any significant change. In experimental protein-calorie malnutrition in rats, the first serum protein to show a significant reduction was C3. This was followed by transferrin and then albumin. On refeeding the rats these serum proteins returned to normal values in the same order.

Animals↗
PubMed1975

Acute phase proteins in children with protein-calorie malnutrition.

The serum concentrations of the acute phase proteins, C-reactive protein, caeruloplasmin and haptoglobin were significantly higher in children with protein-calorie malnutrition than in age-matched controls, while the concentrations of alpha1 antitrypsin, alpha2 macroglobulin, transferrin and complement component C3 were significantly lower. During rehabilitation and treatment with antibiotics, C-reactive protein disappeared from the serum in most of the patients whilst the levels of caeruloplasmin and haptoglobin returned to normal values. On the other hand the serum concentration of alpha1 antitrypsin, alpha2 macroglobulin, transferrin and C3 showed significant increases. It is suggested that C-reactive protein and haptoglobin may provide useful indices of the presence or absence of infection in children with malnutrition.

Blood Proteins↗