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Biomedical subjects

B R Møller

Publications and source records attributed to B R Møller.

At least 37 records · Page 2Linked to original sources
PubMed1990

Occurrence of Ureaplasma urealyticus and Mycoplasma hominis in non-gonococcal urethritis before and after treatment in a double-blind trial of ofloxacin versus erythromycin.

The efficacy of ofloxacin, a new quinolone derivate, was tested against that of erythromycin in a prospective double-blind trial in patients with non-gonococcal urethritis (NGU) with special reference to the occurrence of Mycoplasma hominis and Ureaplasma urealyticum. 188 male NGU patients were randomized to treatment with either ofloxacin 200 mg b.i.d. or erythromycin 500 mg b.i.d. for seven days. Before treatment eight (4.3%) patients, five in the erythromycin group and three in the ofloxacin group, were M. hominis positive. At follow-up day 8 and 15 after start of treatment all five in the erythromycin group and two in the ofloxacin group were still positive. U. urealyticum was recovered in 16 patients (8.5%) before treatment. One patient was still positive in the erythromycin group when examined day 15, whereas all patients were negative in the ofloxacin group at both follow-up controls. Clinically, the efficacy of treatment day 15 was 77.4% in the erythromycin group and 84.3% in the ofloxacin group. The difference was not significant. Side-effects occurred in 38.5% in the erythromycin group and in 21.3% in the ofloxacin group. This difference is significant. Ofloxacin is effective in the treatment of NGU in males and is an alternative to conventional antibiotic treatment.

Double-Blind Method↗
PubMed1989

[Demonstration of urogenital Chlamydia infection by means of the Chlamydiazyme test].

Abbott's recently introduced Chlamydiazyme test which is based on the Elisa principal and cell culture technique was employed with the object of demonstrating urogenital infection with Chlamydia trachomatis in 150 persons. Neither of the methods were optimal. The Chlamydiazyme test had a lower sensitivity and specificity than the cell culture method.

Chlamydia Infections↗
PubMed1988

Fleroxacin in the treatment of uncomplicated acute cystitis in women.

Twenty-four women with uncomplicated acute lower urinary tract infections proven by significant pretreatment bacteriuria (greater than or equal to 10(5) cfu/ml) were treated with a single oral dose of either 200 or 400 mg fleroxacin. Patients were checked for response to treatment five to nine days post therapy. Of the 24 patients initially included in the study, five were not available for assessment of efficacy. In 17 of the remaining 19 women bacteriological cure was achieved.

Acute Disease↗
PubMed1988

Pivampicillin compared with erythromycin for treating women with genital Chlamydia trachomatis infection.

In a randomised single blind study, pivampicillin was compared with erythromycin in women with urogenital Chlamydia trachomatis infections. The pivampicillin dosage was 700 mg twice a day and the erythromycin dosage 500 mg twice a day for seven days. Follow up took place on days 7 and 14 after the start of treatment. All 26 women treated with pivampicillin were culture negative for chlamydiae at the first and second follow up visits. All 23 women who received erythromycin were culture negative at the first follow up visit, but one was culture positive at the second follow up visit. Gastrointestinal side effects were recorded in five patients receiving pivampicillin and in nine receiving erythromycin. Two patients receiving erythromycin were withdrawn from treatment because of gastrointestinal disturbances, compared with none receiving pivampicillin.

Adolescent↗
PubMed1987

The effect of oxytocin injection into the umbilical vein for the management of the retained placenta.

In a single-blind study 51 patients with retention of the placenta were randomized into one of three groups: Group 1 was given 10 IU of oxytocin in 10 ml of sodium chloride into the umbilical vein; group 2 was given 10 ml of sodium chloride; group 3 was treated with manual removal of the placenta. No significant differences were recorded in groups 1 and 2, and no advantages were found in comparison with the procedure normally used.

Clinical Trials as Topic↗
PubMed1987

Isolation of Gardnerella vaginalis in pure culture from the uterine cavity of patients with irregular bleedings.

Hysterectomy was performed in three patients because of persistent irregular vaginal bleeding. Before the operation samples were taken from the cervical os for cultivation of Gardnerella vaginalis, yeasts, viruses, Chlamydia trachomatis, and aerobic and anaerobic bacteria. Immediately after the operation, the uterus was opened under sterile conditions and samples obtained from the isthmus and fundus of the uterine cavity were examined microbiologically. In all three patients G. vaginalis was grown in pure culture from the fundus. Serum antibody titres against G. vaginalis were significantly raised in all three patients, and histology revealed mononuclear cells in the endometrium. The isolation of G. vaginalis from the endometrium of patients with clinical and histological signs of inflammation and with antibodies to G. vaginalis in serum indicates that the organism may play a causative role in endometritis.

Adult↗
PubMed1987

Animal models of Mycoplasma genitalium urogenital infection.

Male and female animals were inoculated urogenitally with Mycoplasma genitalium, recovered originally from men with nongonococcal urethritis. Mice, hamsters and male rhesus monkeys (Macaca mulatta) were resistant. Male cynomolgus monkeys (Macaca fascicularis) were not as sensitive as male chimpanzees (Pan troglodytes): 9 of 11 developed an obvious genital tract infection, some shedding organisms for more than 18 weeks. M. genitalium was recovered from the blood of two of them when large numbers of organisms were in the urethra. Most of the chimpanzees colonized with the organisms had increased numbers of polymorphonuclear leukocytes in the genital tract and developed a fourfold or greater antibody response. Female squirrel monkeys (Saimiri sciureus) and female tamarins (Saguinus mystar) exhibited low-level genital tract infections following intravaginal inoculation, whereas marmosets (Callithrix jacchus) and chimpanzees developed prolonged infections after similar inoculation; thus, female chimpanzees shed organisms for 12 to 15 weeks. Marmosets and grivet monkeys (Cercopithecus aethiops) developed salpingitis with antibody responses after intraoviduct inoculation, and baboons (Papio anubis) developed parametritis after intracervical inoculation. The results offer substantial evidence for the pathogenicity of M. genitalium for the urogenital tract of subhuman primates, and suggest that the microorganism may have a role in human genital tract infections.

Animals↗
PubMed1986

The effect of interferon on human papillomaviruses associated with cervical intraepithelial neoplasia.

A double-blind, placebo-controlled, trial of leucocyte interferon showed that, contrary to previous reports, interferon had no significant effect on cervical intraepithelial neoplasia (CIN) when applied topically in a gel. DNA hybridization of cervical scrapes was used to monitor the effect of interferon on the human papillomaviruses (HPV) associated with CIN. There was, however, no significant difference in the expression of HPV 6 or 16 in the cervical epithelium of patients treated with interferon compared with those given a placebo. By using superficial cells scraped from the surface of the cervical epithelium as a source of DNA for viral studies, we were able to investigate the relation between HPV and CIN without interfering with the natural history of the disease. HPV 16 was detected in lesions which persisted while HPV 6 only was detected in one lesion that regressed. Regression was clearly associated with reduction in the number of copies of viral DNA per cell in this case. Dual infection with HPV types 6 and 16 were recorded in two patients with persistent lesions. In one patient, hybridization studies indicated that infection with HPV 16 could have occurred after infection with type 6 was established, and it is postulated that this may have changed the nature of the cervical lesion.

Adolescent↗