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Biomedical subjects

B R Møller

Publications and source records attributed to B R Møller.

82 records · Page 5Linked to original sources
PubMed1978

Therapeutic abortion in an out-patient clinic. A prospective investigation of complications and patient acceptability.

The incidence of complications associated with therapeutic termination of pregnancy was analysed in 1349 patients, whose average age was 26.3 years. Of the patients, 51.8% were 25 years or under; 56.3% were seen in or before the 8th week of pregnancy, and 17.4% had previously had one or more legal abortions. All the operations were performed under local anaesthesia and by the same doctor, who was an experienced gynaecologist. Complications associated with the operation occurred in 14 patients (1%), viz. infections in the uterus and tubes, 9 cases; incomplete abortion necessitating repeat curettage, 4 cases; and profuse bleeding requiring blood transfusion, 1 case. No uterine perforations or cervical ruptures were encountered. Questioned about subjective discomforts of the opeation, 7.4% of the women answered that the discomfort had been considerable, whereas 62.6% described it as only slight; 4.8% would have perferred general anaesthesia. We conclude that therapeutic abortion can be performed safely and with an acceptably low incidence of complications in out-patients, provided the operations are performed by an experienced gynaecologist.

Abortion, Therapeutic↗
PubMedDate not supplied

Detection of Chlamydia trachomatis in formalin-fixed endometrial tissue.

Formalin-fixed tissue biopsies from 29 women with the histological diagnosis of severe endometritis were examined for chlamydial antigen by fluorescein-conjugated monoclonal chlamydial antibodies (SYVA) technique; 15 (52%) were positive. In nine patients also samples for isolation of Chlamydia trachomatis by cell-culture technique were obtained peroperatively; seven were culture-positive. In all these patients fluorescent chlamydial antigen was detected, whereas the two culture-negative patients had no such antigen. The technique presented makes it possible to examine series of formalin-fixed endometrical biopsies to evaluate the significance of C. trachomatis being etiologic agent in endometritis in females.

Adolescent↗
PubMedDate not supplied

Prophylaxis with lymecycline in induced first-trimester abortion: a clinical, controlled trial assessing the role of Chlamydia trachomatis and Mycoplasma hominis.

A clinical, controlled trial was performed to study the effect of prophylaxis with lymecycline and the role of Chlamydia trachomatis and Mycoplasma hominis in postabortal genital infection. Of 532 women who were to undergo first-trimester abortion, 269 were randomized to treatment with oral lymecycline (300 mg bid) starting 2 days before the abortion and continuing for a total of 7 days, and 263 were randomized to placebo treatment. The rate of postabortal infection was 9.3% in the antibiotic group and 9.5% in the placebo group, an insignificant difference (P greater than .8). The presence of C. trachomatis in the cervix/urethra at the time of abortion showed a significant association with the occurrence of postabortal infection (P less than .005), but there was no correlation between the effect of treatment and the presence of infection (P greater than .4). The presence of M. hominis, a history of pelvic inflammatory disease, maternal age, gestational age, the number of births, spontaneous and induced abortion, and the Hegar number showed no significant association with postabortal infection (all P values greater than .05). It is recommended that women who are to undergo induced abortion be examined for the presence of C. trachomatis and treated, as they constitute a risk group.

Abortion, Induced↗
PubMedDate not supplied

Treatment of nongonococcal urethritis: comparison of ofloxacin and erythromycin.

Ofloxacin, a new quinolone carboxylic acid derivative, has been reported to be effective and safe in the treatment of nongonococcal urethritis (NGU). In the present investigation 188 male outpatients with NGU were randomized to double-blind treatment with either erythromycin (500 mg twice a day) or ofloxacin (200 mg twice a day) for seven days. Before therapy Chlamydia trachomatis was isolated from 43.6% of the patients. One relapse and one reinfection occurred in the erythromycin-treated group, whereas all patients in the group given ofloxacin were culture-negative at follow-up. Among the C. trachomatis-positive group of patients, the clinical efficacy of ofloxacin was 83.7%, and that of erythromycin, 77.4% at the final follow-up. In the C. trachomatis-negative group, the efficacy of ofloxacin was 93%, and that of erythromycin, 84.3%. The differences are not significant. No serious adverse effects were demonstrated. The results indicate that ofloxacin might be a valuable alternative for the treatment of NGU in men.

Adult↗
PubMedDate not supplied

The role of mycoplasmas in the upper genital tract of women.

Mycoplasma hominis is isolated from the cervix of 10-20% of healthy, fertile women. In contrast, the organism is recovered from the lower genital tract of 50-70% of women with pelvic inflammatory disease. Moreover, a significant antibody response to M. hominis is found in one-fourth of all patients with clinical and/or laparoscopic signs of pelvic inflammatory disease. These results suggest that M. hominis is etiologically involved in inflammation in approximately 25% of patients with acute pelvic inflammatory disease and in approximately 40% of women from whose cervix the organism is isolated.

Antibodies, Bacterial↗
PubMedDate not supplied

Mycoplasma hominis and interstitial cystitis.

Antibodies to Mycoplasma hominis were detected by indirect hemagglutination in nine (56%) of 16 patients with chronic interstitial cystitis. In seven patients (44%), titers of greater than or equal to 160 were found. Antibodies to Ureaplasma urealyticum were detected in three (19%) of these patients; in only one patient was a high titer, i.e., greater than or equal to 160, found. M. hominis was isolated from voided urine of two patients, and U. urealyticum was recovered from the urine of three patients. A similar incidence of antibodies to M. hominis was found in 20 age- and sex-matched women treated transurethrally for bladder tumors. The high incidence of indirect hemagglutination antibodies to M. hominis found in these two groups of urologic patients who were subjected to repeated instrumentation of the urinary tract remains unexplained.

Adult↗
PubMedDate not supplied

Monkey animal model for study of mycoplasmal infections of the urogenital tract.

Various experimental monkey models have been used for the study of mycoplasmal infections of the urogenital tract. Direct inoculation of Mycoplasma hominis and Ureaplasma urealyticum into the urethra of male monkeys resulted in successful reisolation of the organisms from the urethra without giving rise to signs of urethritis during the observation period. The organisms were inoculated into the posterior fornix of the vagina of female grivet monkeys. During the ten-week observation period, there was no clinical, histologic, or serologic evidence of lower genital tract infection. Inoculation of M. hominis and M. fermentans into the upper genital tract of grivet monkeys produced parametritis and salpingitis. It was concluded that grivet monkeys are apparently suitable for study of the pathogenicity of genital mycoplasms.

Animals↗
PubMedDate not supplied

Isolation of Mycoplasma hominis from genital ulcerations of patients in Eastern and Southern Africa.

In three separate surveys involving 413 patients in Mbabane (Swaziland), Nairobi (Kenya), and Carletonville (South Africa), Mycoplasma hominis was isolated from the base of ulcers in 41 (16%) of 251 men with genital ulcer disease. Antibodies to M. hominis were detected by indirect hemagglutination in 89 (51%) of 176 such patients. Of these male patients, 15% and 6% had indirect hemagglutinating antibodies at titers of greater than or equal to 160 and greater than or equal to 640, respectively. The rate of isolation of M. hominis and the results of serologic tests for antibodies to this organism were the same whether or not a cause of genital ulcer disease was identified.

Antibodies, Bacterial↗
PubMedDate not supplied

Infection with Chlamydia trachomatis, Mycoplasma hominis and Neisseria gonorrhoeae in patients with acute pelvic inflammatory disease.

Of 166 women with acute pelvic inflammatory disease, Mycoplasma hominis was isolated from the cervix of 91 (54.8%), Chlamydia trachomatis was isolated from 37 (22.3%), and Neisseria gonorrhoeae was isolated from nine (5.4%). Of the 91 women from whom M. hominis was recovered, 39 developed a significant change in titer of serum antibodies to the organism within one month after admission. Of the 85 patients from whose cervix M. hominis was not isolated, 11 displayed a significant change in titer of antibody to the organism. A change in the titer of IgG antibodies to C. trachomatis was found in 20 women (54.1%) who had Chlamydia-positive cultures and in 14 (10.9%) whose cultures were negative for Chlamydia. The results of the cultural and serologic studies suggest that M. hominis was associated with pelvic inflammatory disease in approximately one-third of the patients, or in half of those women from whose cervix the organism was isolated. In approximately every fifth woman studied, C. trachomatis seemed to be associated with the pelvic inflammation.

Acute Disease↗