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Biomedical subjects

B Shopsin

Publications and source records attributed to B Shopsin.

25 records · Page 2Linked to original sources
PubMed1975

Cogwheel rigidity related to lithium maintenance.

Neurological examinations of 27 outpatients receiving lithium carbonate maintenance therapy for recurrent affective illness revealed that most of the patients receiving lithium for more than 8 months had cogwheel rigidity. The data suggest a positive correlation between the duration of lithium maintenance and the severity of cogwheeling. Intravenous administration of benztropine, an antiparkinsonian drug, did not abolish or significantly ameliorate this symptom.

Adult↗
PubMed1975

The influence of dietary iodine on lithium blood level, serum T4 and thyroid gland weight.

Lithium is both antithyroid and goitrogenic. The relationship between lithium and iodine has been assessed in rats fed diets containing different iodine content. Chronic lithium treatment caused increase in thyroid gland weight in animals on low and high iodine diets. A reciprocal relationship surfaced between serum lithium levels and dietary iodine content. Animals on low-iodine diet had lower serum lithium levels. The data support other evidence that lithium likely inhibits organification of iodine by a Wolff-Chaikoff-like effect.

Animals↗
PubMed1975

Use of synthesis inhibitors in defining a role for biogenic amines during imipramine treatment in depressed patients.

Endogenously depressed patients who showed an antidepressant response to the tricyclic drug imipramine continued to show sustained well being after alpha-MPT was added whereas depression returned when small doses of PCPA were added for brief periods. In one patient the antidepressant response to imipramine occurred after pre- and continued treatment with alpha-MPT. Urinary excretion levels of MHPG in one of the patients studied longitudinally did not correspond to the direction of clinical affective state but did reflect anticipated changes during alpha-MPT treatment. Implications are that serotonergic mechanisms are likely involved in the anti-depressant effects of imipramine in man.

3-Methoxy-4-hydroxyphenylethanol↗