PubMed Health⌕ Search

Biomedical subjects

B V Pinegin

Publications and source records attributed to B V Pinegin.

At least 91 records · Page 5Linked to original sources
PubMed1977

[Quantitative patterns in changes in the intestinal microflora of irradiated mice].

Experiments were conducted on 3 groups of mice, gamma-irradiated in doses of 900, 600 and 300 r. Development of acute radiation sickness was accompained by development of intestinal dysbacteriosis. Characteristic was reduction of lactobacilli content and increase in the content of purulent microbes (E. coli, clostridia, Proteus, and enterococcus) in the large intestine, and an increase of enterococcus and Proteus content in the small intestine. Changes in the microbial count in the intestine, depending on the time lapse after the irradiation can be represented as a formula of linear dependence; this permitted to compare the rate of changes in the intestinal content of the microbes during the development of acute radiation sickness.

Acute Disease↗
PubMed1975

[Study of the immunodepressive effect of passive immunization on a model of adaptive immunity].

The effect of various doses of specific serum administered in passive immunization on the formation of primary and secondary adaptive immunity in mice of the CBA strain was studied. Primary and secondary response was more sensitive to passive immunization on a model of adaptive immunity than in vivo. Most sensitive to the immunodepressive action of specific antibodies IgM and IgG were plaque-forming cells, and most resistant -- rosette-forming cells and cells. This led to a supposition that antibodies administered in passive immunization depressed the development of the immunological response acting at the level of T- and B cells.

Animals↗
PubMed1975

[Conditions of development of a secondary immune response in guinea pig lymphoid cell cultures].

On addition of a specific antigen to the cell culture of the lymph nodes of the immunized guinea pigs there was seen an intensification of the synthesis of the DNA and of the antibody formation. Both processes occurred more intensively in incubation of cells on a medium with an addition of rabbit antiserum to the guinea pig erythrocytes than on a medium with a normal homologous serum. It is supposed that the optimal conditions for the initiation of antibody formation in the lymphoid cells were created in case of a combined action of a specific antigen-inductor and a nonspecific stimulant intensifying the DNA synthesis.

Animals↗