Biomedical subjects

Bagavathi S Perumal

Publications and source records attributed to Bagavathi S Perumal.

4 recordsLinked to original sources

PubMed2005

Intron position conservation across eukaryotic lineages in tubulin genes.

A compilation of intron positions obtained from a large number of eukaryotic genomes across orthologous tubulins is explored for molecular evolution. Comparison of intron positions for 41 alpha, 80 beta, and 30 gamma tubulin genomic sequences indicates that the putative ancestral tubulin gene contained at least 19, 33, and 52 intron positions distributed at different sites in the coding regions for alpha, beta, and gamma tubulins, respectively. Many intron positions are old and are conserved across different eukaryotic lineages and intron distribution patterns are consistent with 'introns-early' hypothesis.

Animals↗

PubMed2005

Human genome -- from pieces to patterns.

A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.

Base Sequence↗

PubMed2005

An analysis on gene architecture in human and mouse genomes.

A comparative genome analysis on exon-intron distribution profiles is performed for human and mouse genomes to deduce similarities and differences between them. Interestingly, both in human and mouse genomes, the total length in introns and intergenic DNA on each chromosome is significantly correlated to the chromosome size. The results presented provide a framework for understanding the nature and patterns of exon-intron length distributions, the constraints on them and their role in genome design and evolution.

Animals↗

PubMed2004

Alternatively spliced human genes by exon skipping--a database (ASHESdb).

UNLABELLED: Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. Exon skipping is the most commonly known alternative splicing mechanism. A comprehensive database of alternative splicing by exon skipping is made available for the human genome data. 1,229 human genes are identified to exhibit alternative splicing by exon skipping. AVAILABILITY: http://sege.ntu.edu.sg/wester/ashes/.

Alternative Splicing↗