Human genome -- from pieces to patterns.

Meena Kishore Sakharkar; Pandjassarame Kangueane; Bagavathi S Perumal; Vincent Tak Kwong Chow; Eric Sorscher; Kishore R Sakharkar; Aubrey Hill

doi:10.2741/1721

PubMed · 15970519

Human genome -- from pieces to patterns.

Meena Kishore Sakharkar·Pandjassarame Kangueane·Bagavathi S Perumal·Vincent Tak Kwong Chow·Eric Sorscher·Kishore R Sakharkar·Aubrey Hill

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Abstract

A profile of exon-intron lengths in genes shows a normal distribution. This observation suggests that different genes may have portions of their total exon and/or intron lengths in common. In order to explore the common exon-intron structural patterns that may arise due to common lengths across genes, we compared the exon-intron length patterns of annotated human genes. We discovered 1762278 conserved arrangements of exon-intron length across the otherwise unrelated and diverse genomic landscape. The existence of common exon-intron length patterns across unrelated genes suggests for their role of in gene assemblage and human genome design and architecture.

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Base Sequence Exons Genome, Human Humans Introns Molecular Sequence Data Sequence Analysis, DNA Journal Article Research Support, Non-U.S. Gov't

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Meena Kishore Sakharkar, Pandjassarame Kangueane, Bagavathi S Perumal, Vincent Tak Kwong Chow, Eric Sorscher, Kishore R Sakharkar, Aubrey Hill. 2005-09-01. Human genome -- from pieces to patterns.. https://doi.org/10.2741/1721

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