Biomedical subjects

C A Silverman

Publications and source records attributed to C A Silverman.

At least 19 recordsLinked to original sources

PubMed2001

Bone conduction impairment in chronic ear disease.

The preoperative and postoperative bone conduction (BC) thresholds were prospectively investigated in 24 patients with chronic ear disease in the form of cholesteatoma, chronic suppurative otitis media, or adhesive otitis media. All underwent tympanoplasty with mastoidectomy. Ossicular reconstruction was performed in 14, and the remaining 10 were still awaiting second-stage ossicular reconstruction at the time of this investigation. In each group, the postoperative results were compared with the preoperative results by the paired-samples t-test. In the ossicular reconstruction group, the results revealed a significant improvement in the postoperative BC thresholds, as compared with the preoperative BC thresholds, at 250, 1,000, and 2,000 Hz, with the largest mean improvement observed at 2,000 Hz. No significant improvement was observed at any frequency for the group without ossicular reconstruction. Postoperative improvement of at least 10 dB at 2 or more frequencies was observed in 71% of the ossicular reconstruction group, as compared with 0% of the group that did not undergo ossicular reconstruction. The results support the theory that the elevated BC thresholds of patients with chronic ear disease result from the elimination, due to disease, of the middle ear contribution (from the inertial ossicular component and ossicular resonance) to the BC response. The results also suggest that the middle ear contribution to the BC response is restored with ossicular reconstruction.

Adult↗

PubMed2000

Facial-motion analysis with a video and computer system: a preliminary report.

HYPOTHESIS: To investigate the feasibility of a video and computer-assisted system for evaluating the temporal and spatial aspects of facial motion during selected facial expressions in a pilot group of six normal adults. Evaluation of the diverse medical and surgical treatments for facial paralysis and paresis cannot occur until objective, reliable, and sensitive measures of the spatial and temporal aspects of facial function at specific facial landmarks are developed. METHODS: Facial motion at predetermined facial locations was assessed using a commercially available computer-interactive motion analysis system, which is based on videography principles. The displacement, velocity, and acceleration data were averaged across all trials and subjects. Time plots also were obtained for the left versus right side. RESULTS: The greatest mean maximum displacement (resultant vector) occurred during the eyebrow lift expression, reaching 1.2 cm in magnitude. The mean maximum velocity (resultant vector), which ranged from 4.5 to 8.5 cm/s for the dynamic facial expressions, was greatest for the eyes closed tight expression. The mean maximum acceleration (resultant vector), which ranged from 193 to 465 cm/s/s, was greatest for the eyebrow lift expression. Symmetrical time plots were obtained. The system documented synkinesis by revealing substantial left upper eyelid motion during the nose-wrinkle expression in an illustrative case with slight left facial dysfunction. CONCLUSION: This approach to facial motion analysis is feasible for the simultaneous, multiregional, spatial-temporal assessment of facial expressions. Because motion at relatively remote regions could be quantified, this approach is potentially useful for the evaluation of synkinesis.

Adult↗

PubMed2000

Eustachian tube endoscopy in patients with chronic ear disease.

OBJECTIVES/HYPOTHESIS: A paucity of research exists on trans-eustachian tube endoscopy to evaluate the status of the eustachian tube. Fuller examination of the role of the eustachian tube in chronic ear disease is needed, particularly because the eustachian tube has been implicated in the chronicity and pathogenesis of chronic ear disease. Therefore the purpose of this study was to evaluate the eustachian tube, based on observations from trans-eustachian tube endoscopy. STUDY DESIGN: Twenty-two adult patients with chronic ear disease gave informed consent to participate in a prospective, trans-eustachian tube endoscopic investigation. METHODS: Flexible, fiberoptic, nonarticulating (outside diameter of 0.5 mm) and articulating (outside diameter of 1.0 mm) endoscopes (coherent fused bundle of 3,000 pixels) were employed. The eustachian tube endoscopy was performed under general endotracheal anesthesia as the initial part of a larger, otological surgical procedure for chronic ear disease. The endoscope was passed from the middle ear (transtympanic approach) to the nasopharynx. RESULTS: The 0.5-mm endoscope passed entirely through the eustachian tube from the tympanic orifice into the pharyngeal orifice in 16% of the cases. Stenotic blockage occurred at the infundibulum in 37%, isthmus in 42%, and fossa of Rosenmuller in 5% of cases. The eustachian tube mucosa was abnormal in 64% of cases. The risk for abnormal eustachian tube mucosa was four times greater for persons with long-standing disease (> or = 20 y) than for persons without long-standing disease (<20 y). The mean therapeutic efficiency of ossicular reconstruction was higher for the subgroup with normal than for the subgroup with abnormal eustachian tube mucosa. CONCLUSIONS: The findings of trans-eustachian tube endoscopy provide objective evidence concerning eustachian tube status in persons with chronic ear disease and have implications for the timing of surgical intervention (ossicular reconstruction).

Adult↗

PubMed2000

Central auditory processing disorders and reduced motivation: three case studies.

The central auditory test results for three normal-hearing children who were initially diagnosed as having a central auditory processing disorder and learning disability are presented. They were referred to the authors for second-opinion consultations. Central auditory processing retesting was performed by the authors under the condition of no reinforcement and then the condition of reinforcement with the child's favorite food, hobby, or toy. For all three cases, the central auditory test scores improved markedly bilaterally under the condition of reinforcement as compared with the condition of no reinforcement. We hypothesize that the improvement was related to increased motivation associated with the reinforcement and that these children represented false-positive results on the central auditory test battery. Large-sample studies are needed to investigate the effect of reinforcement on test performance in children with reduced central auditory test scores.

Child↗

PubMed1998

Audiologic assessment and amplification.

The basic audiologic tests (audiogram, speech recognition, and acoustic-immittance), special audiologic tests (otoacoustic emissions and auditory-evoked potentials), and screening protocols, including universal hearing screening, are discussed. Hearing and acoustic-immittance screeners are evaluated. This article also reviews advances in hearing and sensory aids and assistive-listening devices.

Acoustic Impedance Tests↗

PubMed1998

Asymmetric suprathreshold speech recognition and the telephone ear phenomenon.

We compared interaural suprathreshold speech recognition scores in 62 adults with sensorineural hearing loss. Subjects were tested at two sites, 25 at the Baylor College of Medicine, Houston, TX and 37 at Brooklyn College, Brooklyn, NY. Ears were categorized according to telephone usage. Results showed, at both sites, a small but significant difference in speech understanding scores between the ear habitually used on the telephone and the opposite, nontelephone ear. The average speech recognition score was approximately 5 percent better on the telephone ear. Results are interpreted in relation to the theories of auditory deprivation and auditory acclimatization.

Adult↗

PubMed1995

Acoustic-immittance characteristics of children with middle-ear effusion: longitudinal investigation.

The purpose of this investigation was to describe, in a longitudinal prospective study, the acoustic-immittance profile during sessions with effusion and during sessions without effusion in children with recurrent middle-ear effusion (MEE). The static-acoustic middle-ear admittance, tympanometric width (TW), tympanometric peak pressure (TPP), and ipsilateral acoustic reflex (IAR) were evaluated in 36 ears of 18 children with recurrent MEE and 24 ears of 12 children without a history of MEE. Recurrent MEE was operationally defined as MEE diagnosed by microtoscopy and/or pneumotoscopy at four or more sessions over the first year of investigation. Subjects in the recurrent MEE group were followed over a time span of 1.1 to 3.0 years with an average intersession interval of 3.0 months. The results revealed that MEE was present at 78.3 percent of the sessions. A pure-tone average (PTA) exceeding 25 dB HL was present at 80 percent of the effusion sessions in the recurrent MEE group. The false-alarm rate for each of the individual acoustic-immittance measures, especially the TPP and IAR, was markedly higher during the otoscopically normal sessions of the recurrent MEE group than in the control group. This suggests that even when MEE is absent at a particular session, recurrent episodes of MEE appear to alter the acoustic-immittance characteristics of the middle ear. Negative findings on all or three of the four acoustic-immittance measures occurred in only 1 percent of the effusion sessions in the total recurrent MEE group as compared with 76 percent of the normal sessions in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Impedance Tests↗

PubMed1994

Pure-tone assessment and screening of children with middle-ear effusion.

The purpose of this prospective investigation was to evaluate the sensitivity of pure-tone screening of children with middle-ear effusion (MEE) and to describe the short-term audiometric and otologic follow-up of children with MEE who pass versus fail a pure-tone screen. Eighty-two ears of 54 children with MEE based on pneumotoscopy/microtoscopy were investigated. A complete otolaryngologic evaluation, pure-tone screen, then complete audiologic evaluation were performed at the initial test. Retesting was done at 6-8 weeks post initial test. The sensitivity of the ASHA (1985) pure-tone screen to MEE was 54 percent when 500 Hz was excluded, 85 percent when 500 Hz was included, and 89 percent when 250 Hz was also included. Significant air-bone gaps were present in 100 percent of the MEE group that failed and in 92 percent of the MEE group that passed the screen (excluding 500 Hz). Of the cases with MEE at the initial test that returned for the retest, 53 percent to 54 percent continued to show MEE. The mean speech-recognition threshold (SRT) was in best agreement with the hearing-threshold levels at the low frequencies, regardless of the pure-tone screen outcome. The results suggest that 500 Hz, as well as 1000-4000 Hz, should be used in a pure-tone screen at 20 dB HL for detection of MEE. The results also question the assumption in the ASHA (1985) screening guidelines that passing a pure-tone screen at 1000-4000 Hz puts one at low risk for hearing impairments that "interfere with or have the potential for interfering with communication" (ASHA, 1985).

Acoustic Stimulation↗

PubMed1993

Effects of prolonged lack of amplification on speech-recognition performance: preliminary findings.

The purposes of this investigation were two-fold: 1) to prospectively investigate the effect of prolonged lack of binaural amplification in the unaided ears of adults with bilaterally symmetrical sensorineural hearing impairment (BSSHI) fitted monaurally; and, 2) to prospectively investigate the effects of amplification on speech-recognition performance in the aided ears of monaurally and binaurally fitted subjects. Subjects consisted of 19 monaurally aided adults, 28 binaurally aided adults, and 19 control adults. Both ears of the experimental subjects (binaurally and monaurally aided adults) had BSSHI. The speech measures included the W-22 CID suprathreshold speech-recognition test, nonsense syllable test, and speech-perception-in-noise test. Initial testing was done between 6 and 12 weeks following hearing-aid fitting. Retests were performed approximately 1 year following the initial test. The results revealed that the mean aided minus unaided ear score for the nonsense syllable and W-22 tests increased significantly from the initial test to retest, reflecting a slight improvement in speech performance in the aided ear and a slightly greater decrement in the unaided ear. The findings were interpreted with respect to the theories of auditory deprivation and acclimatization.

Acclimatization↗

PubMed1993

Auditory deprivation and recovery in adults with asymmetric sensorineural hearing impairment.

The purpose of this investigation was to investigate (1) whether auditory deprivation effects are present in the poorer ears of adults with asymmetric sensorineural hearing impairment and (2) whether, if such effects are present, they can be reversed by amplification. Subjects were 16 males with asymmetric sensorineural hearing impairment, 8 of whom had never been aided, 6 of whom were aided monaurally at the initial test, and 2 of whom were unaided at the initial test but aided monaurally later on. Data were obtained from a retrospective review of records. The initial and retest (2-13 years post initial test) suprathreshold speech-recognition scores for 50-word, taped lists of the CID W-22 PB words were analyzed. The results revealed a significant difference between the initial and retest mean suprathreshold speech-recognition scores for the poorer ears of the unaided subjects. The results also revealed no significant change from the initial test to retest in six of the aided ears and significant improvement from the initial test to retest in the two of the aided ears. The findings are discussed with reference to the theory of auditory deprivation and recovery from auditory deprivation by amplification.

Acoustic Impedance Tests↗

PubMed1992

Acoustic-immittance screening for detection of middle-ear effusion in children.

The purpose of this investigation was to evaluate the sensitivity and specificity of the following acoustic-immittance protocols and their constituent measures for detection of middle-ear effusion in children: (a) tympanometric width; (b) absent ipsilateral acoustic reflex; (c) ASHA guidelines; (d) tympanometric peak pressure; and (e) static-acoustic middle-ear admittance. The middle-ear sample was composed of 82 ears of 54 subjects ranging in age from 3 to 11 years. The control (normal-hearing, normal middle-ear) sample was composed of 53 ears of 53 subjects ranging in age from 3 to 10 years. Each subject was given a complete otolaryngologic evaluation (including pneumotoscopy and/or microtoscopy) and audiologic (including acoustic-immittance) evaluation. In the group of middle ears with normal-hearing sensitivity, the sensitivity and specificity of the ASHA guidelines were 63 percent and 79 percent, respectively. An acoustic-immittance screening protocol, based on all of the individual acoustic-immittance measures, and characterized by high sensitivity and specificity, is proposed.

Acoustic Impedance Tests↗

PubMed1992

Adult-onset auditory deprivation.

Adult-onset auditory deprivation following prolonged lack of amplification in the unaided ears of persons with bilaterally symmetrical sensorineural hearing impairment was first reported in 1984. This article on the phenomenon includes a review of the literature on adult-onset auditory deprivation in relation to etiology, pathophysiology, hearing-loss manifestations, typical audiologic profile, amplification strategies, contraindications or challenges to conventional hearing-aid fitting, and future research. A case study illustrates the phenomenon of auditory deprivation from monaural amplification with recovery following binaural amplification. The results of a complete audiologic and acoustic-immittance evaluation are presented for a bilaterally sensorineural hearing-impaired male with adult-onset auditory deprivation who initially was fit monaurally and later was fit binaurally. A significant decrement in the suprathreshold word-recognition scores occurred only in the unaided ear following monaural amplification, illustrating the phenomenon of adult-onset auditory deprivation. Following binaural amplification, the suprathreshold word-recognition scores for the formerly unaided ear improved significantly, illustrating the phenomenon of recovery from the adult-onset auditory deprivation with binaural amplification.

Acoustic Stimulation↗

PubMed1990

Apparent auditory deprivation from monaural amplification and recovery with binaural amplification: two case studies.

The suprathreshold word-recognition scores for 2 young, adult males with bilateral, symmetrical sensorineural hearing impairment were evaluated following monaural and then binaural hearing-aid fitting. Subjects were obtained by retrospective review of records. Subject 1 was followed over an approximately 11.5-year time period and Subject 2 was followed over an approximately 6-year period. Results revealed that a significant decrement occurred in the unaided ear following the monaural hearing-aid fitting. Then, significant improvement in the formerly unaided ear occurred following the binaural hearing-aid fitting. The implications with respect to recovery from apparent auditory deprivation after binaural amplification are discussed.

Adult↗

PubMed1989

Contralateral acoustic-reflex growth function in a patient with a cerebellar tumor: a case study.

The contralateral acoustic-reflex growth functions (ARGFs) for 500-Hz and 1000-Hz tonal activators were obtained pre- and postsurgery in a patient with a right cerebellar tumor. The acoustic-reflex magnitude was quantified as the change in equivalent air volume at the tympanic membrane during acoustic-reflex contraction. The presurgical ARGFs were shallow in the right ear and steep in the left ear at both activator frequencies. The postsurgical ARGFs were steep, bilaterally, reflecting a return to normal in the right ear. The implications with respect to the use of the ARGF measure in differential diagnosis are discussed.

Carcinoma, Squamous Cell↗

PubMed1989

Some effects of signal bandwidth and spectral density on the acoustic-reflex threshold in the elderly.

The acoustic-reflex thresholds (ART) for multicomponent tonal complexes of varying bandwidth and spectral density were obtained from 20 normal-hearing (air-conduction thresholds less than or equal to 20 dB HL at 250-8000 Hz) young adults ranging in age from 20-30 years and 20 normal-hearing, old subjects ranging in age from 60-71 years. The results revealed that the ART decreased with spectral density, plateauing after seven components in the young group and after five components in the old group; the decrease in the acoustic-reflex threshold as a result of the increase in spectral density was less in the old than in the young group. The bandwidth effect (when bandwidth was plotted in hertz or octaves) on the acoustic-reflex threshold was present in the young adults, but substantially reduced in the elderly, as evidenced by the statistically significant interaction between subject group and signal bandwidth. The spectral density results are discussed in terms of their theoretic implications for the energy summation capacity and frequency resolution of the auditory system. The bandwidth results are discussed in terms of their theoretic implications for the frequency-resolving power of the auditory system.

Acoustic Stimulation↗

PubMed1988

Ipsilateral acoustic-reflex adaptation testing for detection of facial-nerve pathology: three case studies.

Abnormal acoustic-reflex adaptation monitored in the same ear for both contralaterally and ipsilaterally presented tonal activators is reported in three cases. One case had Bell's palsy, whereas the other two cases had no clinically observable evidence of seventh-nerve involvement. These cases show that the existence of abnormal acoustic-reflex adaptation in the absence of Bell's palsy does not necessarily implicate the presence of eighth-nerve pathology.

Acoustic Impedance Tests↗

PubMed1984

Moxalactam retinal toxicity.

Moxalactam disodium is a new third-generation semisynthetic, broad-spectrum, cephalosporin-like antibiotic for parenteral administration. Topical, subconjunctival, and intravenous administration provide poor concentration in the vitreous. To determine its toxicity in intravitreal administration, we injected comparative doses directly into the vitreous cavity of 21 rabbits. With doses of 1.25 mg or less there was no toxic damage to the retina. With a dose of 2.5 mg, early degeneration of photoreceptors was seen after three months. With higher doses (5 and 10 mg) there were major histopathologic and electroretinographic changes. These results suggest the feasibility of employing moxalactam in the treatment of acute, severe, fulminant bacterial endophthalmitis.

Animals↗

PubMed1984

Effect of age on prediction of hearing loss with the bivariate-plotting procedure.

The effect of age on accuracy of prediction of hearing impairment with the bivariate-plotting procedure was investigated in 72 normal-hearing subjects aged 20-69 years and in 86 sensorineural hearing-impaired subjects aged 20-83 years. The predictive accuracy with the bivariate-plotting procedure improved markedly when the data from subjects over 44 years of age were excluded from the bivariate plot. The predictive accuracy improved further when the construction of the line segments in the traditional bivariate plot was modified.

Adult↗