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Biomedical subjects

C Anger

Publications and source records attributed to C Anger.

26 records · Page 2Linked to original sources
PubMed1984

Influence of ketanserin, an antihypertensive agent with specific 5-HT2-receptor blocking activity, on intracranial pressure.

During administration of ketanserin, a selective 5-HT2-receptor blocker, intracranial pressure (ICP) was measured in dogs without (group 1) and with (group 2) intracranial hypertension (ICP greater than 20 mm Hg). A bolus of 1 mg/kg body weight and subsequent infusion of 13.25 +/- 1.2 mg/kg of ketanserin decreased mean arterial pressure 35% +/- 18% in group 1 and 35% +/- 19% in group 2. In both groups, there was no change in ICP or in ventricular volume-pressure response curves (intracranial compliance [ICC]) after the administration of ketanserin. Ketanserin may be a safe antihypertensive drug for avoiding and treating hypertension in neurosurgical patients.

Animals↗
PubMed1984

Plasma serotonin concentrations during and after cardiac surgery.

Plasma serotonin concentrations, assayed as plasma 5-hydroxyindoles (5-HI) and platelet 5-hydroxytryptamine (5-HT), were measured in 12 patients undergoing coronary artery graft surgery (group 1) and five patients undergoing valve replacement (group 2). Mean values of plasma 5-HI before cardiopulmonary bypass (CPB) were 29.8 +/- 2.0 ng ml-1 in group 1 and 30.6 +/- 2.8 ng ml-1 in group 2. No significant changes of plasma 5-HI occurred during or after CPB in either group. Although postoperative hypertension occurred in 75% of group 1 patients, no significant correlation was found between plasma 5-HI concentration and systolic blood pressure. A significant increase of platelet 5-HT occurred during bypass (327 ng/2 X 10(8) platelets increasing to 488 ng/2 X 10(8) platelets, p less than 0.01) but returned to baseline values postoperatively. We conclude that plasma 5-HI concentrations are not involved in the pathophysiology of postoperative hypertension following myocardial revascularization.

Adult↗
PubMed1984

Changes in intracranial pressure and compliance during adenosine triphosphate-induced hypotension in dogs.

Intracranial pressure (ICP) was measured during induced hypotension with increasing doses of adenosine triphosphate (1-5 mg X kg-1 X min-1 ATP) in dogs without (group I) and with (group II) intracranial hypertension. After administration of 1 mg X kg-1 X min-1 ATP, ICP increased significantly from 11 +/- 4 mm Hg to 14 +/- 5 mm Hg (mean +/- SEM) (P less than 0.05; group I) and from 27 +/- 2 mm Hg to 38 +/- 6 mm Hg (P less than 0.05; group II), while mean arterial pressure (MAP) decreased from 103 +/- 10 mm Hg to 86 +/- 6 mm Hg (P less than 0.05; group I) and from 110 +/- 11 mm Hg to 90 +/- 11 mm Hg (P less than 0.05; group II). In both groups a slow decrease of ICP after the initial increase occurred with further lowering of MAP, but ICP remained significantly above control values even with a dose of 5 mg X kg-1 X min-1 ATP (P less than 0.05). Ventricular volume-pressure response curves (VPR) before and during intravenous infusion of 3 mg X kg-1 X min-1 ATP were constructed to determine changes in intracranial compliance (ICC). In both groups I and II ATP decreased ICC. On the basis of these results it is recommended that in the presence of intracranial mass lesions ATP should not be given to induce arterial hypotension before the dura is opened.

Adenosine Triphosphate↗
PubMed1983

Treatment of hypertension with labetalol in neurosurgical practice. Influence of labetalol on cerebral perfusion pressure in dogs without and with intracranial mass lesions.

In neurosurgical patients autoregulation of cerebral perfusion is often lost. Therefore, a sudden increase in blood pressure may lead to an increase in cerebral blood flow and cerebral oedema may follow. The influence of labetalol, a new alpha- and beta-adrenoceptor blocking agent, on intracranial pressure and cerebral perfusion pressure was investigated in dogs without and with mass lesions. During hypotension with labetalol the intracranial pressure remained unchanged and the cerebral perfusion pressure decreased to the same extent as mean arterial pressure (30%). Labetalol seems to be suitable to treat hypertension perioperatively in neurosurgical patients but it is not a suitable drug for induced hypotension.

Animals↗
PubMed1983

The influence of urapidil, a new antihypertensive agent, on cerebral perfusion pressure in dogs with and without intracranial hypertension.

The influence of urapidil, an arylpiperazinederivate, on intracranial pressure (ICP), mean arterial pressure (MAP) and cerebral perfusion pressure (CPP) was investigated in dogs with (group II) and without (group I) intracranial hypertension. After i.v. administration of urapidil, intracranial pressure remained unchanged and cerebral perfusion pressure decreased to the same extent as mean arterial pressure (20%). As in neurosurgical patients, autoregulation of cerebral blood flow is often lost; a sudden increase in blood pressure may lead to an increase in cerebral blood flow and to a damage of the blood bain barrier with consequent cerebral edema. Urapidil seems to be suitable for treating hypertensive episodes perioperatively in neurosurgical patients.

Anesthesia, Conduction↗
PubMed1983

Influence of urapidil on intracranial pressure and intracranial compliance in dogs.

During induced hypotension with urapidil, measurements of intracranial pressure and of the ventricular volume-pressure response (intracranial compliance) were obtained in dogs with and without intracranial hypertension. A bolus of urapidil 50 mg plus an infusion of urapidil 8.2 +/- 1.2 mg min-1 decreased mean arterial pressure by 22 +/- 10% from control in group I (without intracranial hypertension) and by 24 +/- 8% in group II (with intracranial hypertension). In both groups there was no change in intracranial pressure or in intracranial compliance after the administration of urapidil.

Animals↗
PubMed1982

[Controlled hypotension with ATP. Animal experiment studies in dogs].

Reliable efficacy and short half-time, combined with the absence of tachyphylaxis and reactive hypertension during and after controlled hypotension should be considered important factors in the use of hypotensive drugs. The vasodilating action of adenosine triphosphate (ATP) was investigated for deliberate hypotension in anaesthesized dogs. During a continuous infusion, in which the dose of ATP was increased from 1 mg/kg . min ATP to 5 mg/kg . min ATP, a stepwise decrease in mean arterial pressure (MAP) and systemic vascular resistance (SVR) could be observed (55%; p less than 0.001). Cardiac output and heart rate increased (p less than 0.05). The physiological intrapulmonary shunt remained unchanged during ATP infusion. ATP acts within 30 sec. and after the end of the infusion haemodynamic parameters returned to control levels within two minutes.

Adenosine Triphosphate↗