Biomedical subjects

C Backman

Publications and source records attributed to C Backman.

45 records · Page 3Linked to original sources

PubMed1983

Echocardiographic features in familial amyloidosis with polyneuropathy.

Twenty-two patients with the Swedish variant of familial amyloidosis with polyneuropathy were studied by M-mode and two-dimensional echocardiography. These patients had few symptoms consistent with cardiac disease but, nevertheless, echocardiograms of only two of them, both with a short history of the disease, were considered normal in all aspects. The most common abnormality was increased thickness of the interventricular septum found in 20 (91%) of the patients. This septal hypertrophy was asymmetric in 12 (55%) of them. Two-dimensional echocardiography revealed a characteristic hyperrefractile appearance of the myocardium in 15 (68%) of the patients. Thus, echocardiography showed a characteristic pattern in these patients. This study also indicates that cardiac amyloidosis can be diagnosed in the preclinical, asymptomatic state by M-mode and two-dimensional echocardiography.

Adult↗

PubMed1982

Cor triatriatum.

Explore the source record for details and available documents.

Adult↗

PubMed1982

Serum lipoproteins, apolipoproteins and intravenous fat tolerance in young athletes.

Serum lipoproteins, apolipoproteins and intravenous fat tolerance were studied in 22 male athletes and compared with healthy age and weight-height matched controls. All of the subjects were non-smokers. Athletes had lower serum, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) triglycerides, lower serum VLDL and LDL cholesterol and an increase in apolipoprotein A I. High density lipoprotein (HDL) cholesterol was similar in both groups. The clearance of i.v. injected triglyceride emulsion was faster in athletes. This suggests that the lower serum and VLDL triglycerides in athletes are at least in part due to a more rapid triglyceride clearance.

Adult↗

PubMed1981

Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent.

The pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent was studied in six healthy volunteers after an intravenous dose of 100 mg and oral doses of 100, 200, 400 and 800 mg. The disposition of intravenous tolfenamic acid could be described by two-compartment open model, with a central compartment volume (Vdc) of 5.6 +/- 0.31 (mean +/- SE), volume during beta-phase (Vd beta) of 31 +/- 21, and a total elimination rate constant (k 10) 1.6 +/- 0.1 h-1. The terminal elimination half-life was 2.5 +/- 0.6 h and the total plasma clearance 155 +/- 15 ml/min. The elimination occurred principally by extrarenal mechanisms, the recovery of unchanged drug together with is glucuronide in urine averaging only 8.8% of the intravenous dose. The binding of tolfenamic acid to plasma proteins averaged 99.7%. The gastrointestinal absorption had a mean half-life of 1.7 +/- 0.1 h. Based on comparison of areas under the plasma concentration time-curves after intravenous and oral administration, the biovailability of tolfenamic acid capsules averaged 60%. The rate and extent of absorption and the rate of elimination of tolfenamic acid were independent of dose.

Administration, Oral↗

PubMed1981

Changes in central circulation in premenopausal women during application of an estradiol valerate-norgestrel combination (Cyclabil).

The orthostatic circulatory reaction, the physical working capacity on a bicycle ergometer, the indirectly measured blood pressure at rest and after the ergometer test, the total hemoglobin content, blood volume and the heart volume in supine position were all determined on three separate occasions in the 17 premenopausal women who were taking an estrogen-progestogen combination as premenopausal substitution (2 mg estradiol valerate and 0.5 mg norgestrel, CyclabilR, Schering AG). Twelve women not receiving steroid treatment served as controls. The examinations were performed once prior to the commencement of the medication and 6 and 12 months thereafter. The orthostatic pulse reaction, the physical working capacity, the total amount of hemoglobin and heart volume did not change during the 12 months. Heart volume increased in both groups but there was no difference between the groups. Systolic and diastolic blood pressure increased slightly in the treated group during the first months but returned towards the initial values at 12 months. The transitory blood pressure increase when using the estrogen-progestogen combination in the premenopause during 12 months is similar to that earlier reported in younger women taking low-dose steroid contraceptives (8). It is conceivable that an adaptative mechanism in the vascular system will work in both situations.

Adult↗

PubMed1979

Adjustments of circulation including blood pressure to orthostatic reaction and physical exercise during application of a low estrogen dose steroid oral contraceptive.

The orthostatic circulatory reaction, the physical working capacity on a bicycle ergometer, the blood pressure reactions at rest both during and after the ergometer test, the total hemoglobin content and the heart volume in the supine position were all determined on four separate occasions in 34 nulligravidae who were taking a low estrogen dose steroid oral contraceptive consisting of 30 micrograms of ethinyl estradiol and 150 micrograms of levonorgestrel (known as Neovletta, Schering AG). These examinations were performed once prior to the commencement of this medication, and 6, 12 and 24 months thereafter. The orthostatic pulse and blood pressure reactions taken on these subjects standing upright for a period of eight minutes were pronounced up to and including the 12 month control, but decreased thereafter. Physical working capacity at a pulse rate of 170 beats per minute on the different test occasions decreased up to and including the 12 month control, but thereafter seemed to increase almost to their initial levels. Blood pressure, heart volume and total amount of hemoglobin increased up to and including the 12 month control but thereafter seemed to return to the pre-treatment level. These circulatory changes during the first year of the application of this contraceptive may be as the result of a marked sympathicotonic reaction induced by the steroids. Possibly because of some form of adaptive mechanism, this reaction seems to decrease (and almost to "normalize") during the second year of use.

Adolescent↗

PubMed1979

Reaction to cold of patients with coronary insufficiency.

Twenty six patients with angina pectoris and coronary insufficiency as judged by an exercise ECG test were examined. About half of the patients had more pronounced ECG changes in a cold room at -15 degrees C than at room temperature. They worked less, their subjective rating of exertion during exercise was higher and the heart performed less work, expressed as the heart rate blood pressure product. The other half of the patients was not much influenced by cold. During an exercise test in the supine position almost all patients got more pronounced ECG changes, worked less and the heart performed less work than in the sitting position. It is suggested that cold exposure as well as a supine body position may to a considerable part exert their effect, i.e. lower the anginal threshold and increase ECG changes, by increasing the central blood volume and the diastolic volume of the left heart and thus ceteres paribus the myocardial oxygen consumption.

Adult↗

PubMedDate not supplied

Left ventricular asynergy score as an indicator of previous myocardial infarction.

Sixty-eight patients with coronary heart disease (CHD) i.e. a history of angina of effort and/or previous 'possible infarction' were examined inter alia with ECG and cinecardioangiography. A system of scoring was designed which allowed a semiquantitative estimate of the left ventricular asynergy from cinecardioangiography--the left ventricular motion score (LVMS). The LVMS was associated with the presence of a previous myocardial infarction (MI), as indicated by the history and ECG findings. The ECG changes specific for a previous MI were associated with high LVMS values and unspecific or absent ECG changes with low LVMS values. Decision thresholds for ECG changes and asynergy in diagnosing a previous MI were evaluated by means of a ROC analysis. The accuracy of ECG in detecting a previous MI was slightly higher when asynergy indicated a 'true MI' than when autopsy result did so in a comparable group. Therefore the accuracy of asynergy (LVMS greater than or equal to 1) in detecting a previous MI or myocardial fibrosis in patients with CHD should be at least comparable with that of autopsy (scar greater than 1 cm).

Adult↗

PubMedDate not supplied

Relationships between coronary artery obstruction, asynergy, presence of collaterals and the ejection fraction of the left ventricle in patients with coronary heart disease.

Cardioangiographic scores of coronary artery obstructions and corresponding myocardial involvement (MCOS), presence of collaterals (CollS), and asynergy of the left ventricular wall (LVMS) as well as the left ventricular ejection fraction (EF) were examined in 67 patients with coronary heart disease. A covariation was found between LVMS, EF, ECG changes, and a history indicating a previous myocardial infarction (MI). In a multiple regression analysis the EF covariated with LVMS but not with MCOS and CollS. LVMS indicated a previous MI with at least the same sensitivity and specificity as EF. MCOS and CollS give additional information. Collaterals as well as a high MCOS in relation to the LVMS indicate obstruction of coronary arteries which subserve 'non-fibrotic' myocardium. A patient with a high MCOS and CollS and a low LVMS should be expected to gain most functional improvement from coronary bypass surgery. The scores MCOS, CollS and LVMS are comparatively easy to determine and give a more diversified picture of the state of the myocardium than the EF alone.

Angiocardiography↗