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Biomedical subjects

C Baud

Publications and source records attributed to C Baud.

At least 37 records · Page 2Linked to original sources
PubMed1991

[Demonstration of the presence and localization of the synthesis of a somatostatin-like substance by immunocytochemistry and hybridization in situ in the brain of Helix aspersa].

The immunocytological method has revealed the presence of somatostatin-like substance (SSI) in the brain of the snail Helix aspersa Müller. The Cerebral Green Cells (CeGC) in the mesocerebron and some neurons in parietal and visceral ganglia react positively with an antibody raised against Vertebrate somatostatin-14. The hybridization in situ with an oligonucleotide probe labelled with 35S-dATP complementary to the 3'-coding region of rat preprosomatostatin mRNA seems to show a colocalization between synthesis and stocking sites of SSI in the nervous ganglia. These results suggest for the first time that the codage of a SSI seems to be realized in the same way in Helix aspersa and Mammals.

Amino Acid Sequence↗
PubMed1990

Pericerebral fluid collections and ultrasound.

The authors have studied 142 cases of pericerebral fluid collection, by ultrasound. Three echographic patterns are individualized: anechogenic single compartment (109); thin linear echogenic membrane dividing the pericerebral fluid collection (25); the third group (8) presented with a peripheric echogenic collection. The use of high frequency probes permits the detection of pericerebral effusions, and provides new information about the high incidence. Ultrasound can define the anatomical position and show the complications which are mainly acute subdural hematoma.

Acute Disease↗
PubMed1990

Wegener's granulomatosis with otological disorders as primary symptoms.

Otological symptoms as initial manifestations of Wegener's granulomatosis have been observed in 3 patients. In one of them, symptoms consisted of a bilateral sensorineural hearing loss, improved by corticoid therapy. No other organ system was involved and laboratory tests remained within normal limits for 2 years after the onset of otological signs. In the other 2 patients, Wegener's granulomatosis manifested mainly as serous otitis media. Otologic involvement underscores the role of the otolaryngologist in the early diagnosis and treatment of this disease.

Adult↗
PubMed1987

Ionic basis of membrane potential in developing ectoderm of the Xenopus blastula.

1. The membrane potential and permeabilities of blastomeres isolated from the ectoderm of stage 6-10 Xenopus blastulae have been investigated. The increase in membrane potential between stages 6 and 9, reported previously in intact embryos, is not clearly apparent in isolated cells. However, marked differences were observed between early and late stages. 2. The membrane specific resistance was high at all stages (100-300 k omega cm2) and increased from stage 6 to stage 9. This specific resistance is much higher than previous estimates of the permeability of newly formed membrane after fertilization and very different from values reported for differentiated cells. 3. The membrane Na-K pump activity has been measured at all stages by applying ouabain to the cells (10(-4) to 10(-3) M). The pump rate per unit surface area, calculated as the ratio of the ouabain-sensitive part of the resting potential to the specific resistance, decreased from stage 7 (about 0.19 microA/microF) to stage 9 (about 0.04 microA/microF). 4. The ouabain-insensitive part of the resting potential increased from stage 6 to 9. At all stages, the blastomeres were permeable primarily to K+; blastomeres at stage 9 were more sensitive to change of external K+ than at stage 7, suggesting an increase in K+ selectivity. 5. The membrane potential was very sensitive to external pH at all stages. External protons appeared to block the permeability to K+. At low pH, it was possible to demonstrate some permeability of early blastomeres to Na+. 6. At variable times after impalement, cells underwent an increase in K+ permeability of 5- to 10-fold. This seems to be due to ion leak from the intracellular electrode. 7. This dual membrane state was observed at all stages and it may explain some of the earlier reports of high K+ permeability.

Animals↗
PubMed1987

[Acute intestinal invagination in infants and children, critical evaluation of the diagnostic and therapeutic strategy. Apropos of a series of 163 cases].

This study concerns a homogenous series of 163 cases of intussusceptions in children, seen in the Visceral Pediatric Surgical Unit of Montpellier from 1974 to 1985. The authors differentiate and compare two periods with regard to the year 1980: the first one (P1 = 64 cases) during which, surgery was always the rule;the current one (P2 = 99 cases) where non operative treatment is the modality of choice under precise conditions. Synthetic analysis and comparison of the different therapeutic groups which have been distinguished in every period lead to the following data. 14% of intussusceptions are directly operated whatever the period or the modality of management probably because this group represents the absolute contra-indications of a barium enema--It concerns children with a long duration of the disease, obstructive or peritonitis signs and late diagnosis--Laparotomy is mandatory and finds a high percentage of leading points and ileo-ileal forms. Intestinal resection was necessary in 59.5% of cases. Because of this and a poor general condition, morbidity was high and Hospital stay was long. 56.4% of intussusceptions are operated after failure of barium enema reduction. This hydrostatic irreducibility is probably explained by the prevalence of ileo-colic forms (53.3%) in this group. A shorter duration of the disease (less than 2 days in 43.1%) and a strong majority of idiopathic intussusception (90.5%) are surely responsible of a high percentage (80%) of successful manual reduction without the need of a resection.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1984

Changes in membrane hydrogen and sodium conductances during progesterone-induced maturation of Ambystoma oocytes.

A voltage-gated hydrogen ion-selective conductance has been previously described in the immature oocyte of the urodele amphibian Ambystoma. The present study was prompted by reports that changes in membrane voltage and internal pH, as well as in internal sodium ion concentration, occur during the hormone-induced maturation of oocytes from other amphibians. As activation of membrane currents might mediate changes in internal ion concentrations in addition to altering the membrane voltage, microelectrode recording techniques have been employed to examine changes in membrane conductances which occur during maturation of Ambystoma oocytes. It was observed that during the first 5 hr of maturation the magnitude of the hydrogen ion conductance gradually decreased, and that subsequently there was an increase in the amplitude of a voltage-dependent noninactivating sodium conductance. After 6 to 7 hr, after the loss of the hydrogen conductance and at about the time of germinal vesicle breakdown, the resting potential of the oocyte spontaneously shifted from approximately -10 mV to approximately +30 mV, where it remained until at least 24 hr after the initiation of maturation. This voltage transition was due to the appearance of mechanisms generating inward current in the oocyte membrane; part of this inward current was due to the tonic activation of the sodium conductance. Changes in internal pH and internal sodium ion concentration occurred during maturation, as judged from shifts in the reversal potentials of both hydrogen and sodium currents. A gradual decrease in internal hydrogen ion concentration was observed up until the time of disappearance of the hydrogen conductance (change in internal pH from about 7.15 in immature oocytes to about 7.40 by 3 hr after application of progesterone). This was followed, as sodium conductance increased, by an apparent rise in the internal sodium ion concentration (from about 6 mM to about 17 mM by 10 hr postprogesterone).

Ambystoma↗