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Biomedical subjects

C Carbone

Publications and source records attributed to C Carbone.

At least 91 records · Page 5Linked to original sources
PubMed1987

Glycosilated fetal hemoglobin in neonates of diabetic mothers.

In diabetic patients, the correlation between glycosilated adult hemoglobin (HbA1c) levels and average glucose concentration over the preceding weeks is well known. We have, therefore, sought the possibility to identify newborns at risk measuring cord blood levels of fetal glycosilated hemoglobin (HbF1) in neonates of diabetic mothers. HbF1 was tested by the isoelectrofocusing method. Mean values of HbF1 have been proven to be higher in in infants born to diabetic mothers as compared to normal newborns. The highest levels were encountered in those babies whose mothers had shown a poor glycemic control during the last few weeks of pregnancy.

Female↗
PubMed1986

Effects of a low phosphorus, low nitrogen diet supplemented with essential amino acids and ketoanalogues on serum triglycerides of chronic uremic patients.

The effects were studied of a vegetarian low-protein, low-phosphorus diet supplemented with essential amino acids and ketoanalogues and those of maintenance hemodialysis (MHD) and free diet on the serum triglycerides (STG) of 85 patients with chronic renal failure. Following dietary therapy STG decreased significantly in the 61 male patients (from 185.7 +/- 89.8 to 153.5 +/- 68.7 mg/dl; p less than 0.001), whereas in the females the decrease was not significant (from 189.1 +/- 83.9 to 167.0 +/- 62.2 mg/dl; NS). When patients changed to MHD therapy and free diet STG increased again. We can conclude that the correction of hypogonadism of chronic male uremics largely accounts for the improvement of hypertriglyceridemia, though other factors are likely to contribute.

Adult↗
PubMed1986

Met-enkephalin-like immunoreactivity (MELI) and enkephalinase activity (EKA) in cord blood and newborns in the first hours of life.

Recently, the presence and the concomitant release with catecholamines of metenkephalin and other pro-enkephalin A deriving peptides have been demonstrated in the adrenal medulla of various mammals and man. As high amounts of catecholamines are released in the newborn at delivery, probably following the stress of parturition, a similar release of met-enkephalin and other pro-enkephalin A deriving peptides from the newborn chromaffin tissue may be hypothesized. In the present study we investigate the occurrence of met-enkephalin-like immunoreactivity and enkephalinase (quite a specific enkephalin degrading enzyme) in cord and newborn plasma at different hours after birth. Our results show the presence of high met-enkephalin-like immunoreactivity levels in cord and newborn plasma with respect to normal adult values. On the contrary, cord blood enkephalinase activity was lower than in adult subjects and further decreased during the first hours of life. A positive correlation was found between the two parameters. These data seem to indicate a release of met-enkephalin-like peptides from the newborns' sympathoadrenal tissue following the stress of delivery and in the first hours of life.

Chromatography, High Pressure Liquid↗
PubMed1984

Is peripheral arterial pressure a satisfactory substitute for ascending aortic pressure when measuring aortic valve gradients?

Substitution of peripheral arterial pressure for ascending aortic pressure is a common but poorly validated practice in the assessment of aortic valve gradients by catheterization. The accuracy of this practice was assessed by comparing the left ventricular-ascending aortic mean gradient in 26 cases of aortic stenosis with the left ventricular-femoral artery gradient, both with and without compensation for temporal delay in femoral artery pressure. Aligned left ventricular-femoral artery gradients (matching upstrokes to compensate for peripheral time delay) underestimated the left ventricular-ascending aortic gradient by 10 mm Hg (range 0 to -17). Unaltered simultaneous left ventricular-femoral artery gradients overestimated the left ventricular-ascending aortic gradient by an average of 9 mm Hg (range +1 to +18). For both peripheral techniques, the error was relatively constant throughout the range of aortic valve gradients. The most accurate estimate of both aortic valve gradient and area was obtained by averaging the gradients and areas derived from aligned and unaltered left ventricular-peripheral arterial simultaneous tracings. Although only occasionally critical for clinical decision-making, these errors may be overwhelming in certain types of research applications, such as comparisons of valve prosthesis gradients and serial evaluations of aortic stenosis. An additional source of error is a coexistent peripheral arterial gradient that was present in 21% of otherwise technically suitable patients in the screened study group.

Aorta↗
PubMed1978

[An epidemiological study of congenital heart disease. I. Incidence of cardiovascular malformations in 11,584 live-born babies in the District of Florence (Italy) (author's transl)].

11,584 consecutive live-born babies in the Ostetric Clinic of Florence in the years 1975 and 1976 were examined for the presence of congenital heart disease. Diagnosis was made by necropsy, cardiac catheterization and operation in 20% of cases and by clinical observations in 80%. The 74% of babies who were diagnosed as affected by congenital heart disease at birth were eventually controlled. The incidence of congenital heart disease was 7.1% in 10,789 live-born of weight over 2500 g while it was 37% in 795 under such weight. Global incidence was 9.2%. The first essentials in epidemiological study of congenital heart malformations is to define the method which is used for diagnosis since this is the primary factor responsible for wide variations in incidence. It is suggested that the institution of a Regional Register of malformations would allow more accurate estimate of overall incidence of congenital cardiopathies.

Abnormalities, Multiple↗